NUR 521 Advanced Pharmacology –
complete Exam 4 Questions With Correct
Answers| Updated
Furosemide (Lasix) Class
Loop diuretic
Furosemide (Lasix) MOA
Acts in the thick segment of the ascending limb of the loop of Henle. Blocks reabsorption of Na/
Cl, preventing reabsorption of H2O.
Produces profound diuresis
Furosemide (Lasix) use
When rapid or massive mobilization of fluid is needed. Pulmonary edema associated with CHF,
Edema from heart, liver, or kidney that has not responded well to other drugs, HTN
Furosemide (Lasix) caution
CV disease, Renal impairment, DM, PMH of gout (can cause
,a flare-up), Pregnancy, Ototoxic drugs, NSAIDS, antihypertensives
Furosemide (Lasix) Dosing/ Admin
20, 40, 80mg tabs; IV dose available; onset within
60min ; duration 6-8hrs; usual dosage 20-80mg (1-2 times/day); start at low dose and gradually
increase
Why is Furosemide (Lasix) especially helpful for patients with renal impairment?
because diuresis can be produced even if there is a lack of renal blood flow and even when GFR
is decreased
DI for Furosemide
Digoxin (due to loss of K it can INC Digoxin levels and cause dysrhythmias), Other Ototoxic Drugs
(gentamycin) should be AVOIDED, K Sparing Diuretics (can negate the wasting some and is
sometimes combined w/ Furosemide), NSAIDS, Antihypertensive agents, Lithium
Furosemide AE
Hyponatremia
Hypokalemia
Hypochloremia
Hypotension
Dehydration
Hyperglycemia
,Hyperuricemia
INC LDL and TGs
DEC HDL
Ototoxicity**
Pt edu for furosemide
Monitor BP; S/S of ortho hypotension (rise slowly to avoid), K rich foods, s/s of dehydration
BBW for furosemide
All loop diuretics can cause profound diuresis with water and electrolyte depletion
(hypokalemia s/s: constipation, palpitations, fatigue, muscle weakness, tingling, numbness)
Hydrochlorothiazide (Microzide) drug class
Thiazide diuretic
Hydrochlorothiazide (Microzide) MOA
Acts in the early segment of the distal convoluted tubule.
Promotes urine production by blocking reabsorption of Na and Cl leading to water retention in
the nephron and increased urine flow.
More mild diuresis compared to Furosemide (Lasix)
Must have adequate GFR of at least 20mL/min
Steroid derivative
, Hydrochlorothiazide (Microzide) Use
HTN
Edema in CHF, Hepatic, or Renal disease
Hydrochlorothiazide (Microzide) Caution
CV disease, Renal impairment, DM, PMH of gout (can cause
a flare);
Meds: Digoxin, Lithium, Antihypertensive drugs
Hydrochlorothiazide (Microzide) Dosing/ Admin
12.5mg capsules; 12.5, 35, 50mg tablets; onset- 2hrs;
peaks- 4-6 hrs ;duration 6-12 hrs; usual dose- 12.5-25mg/day. Start low and adjust carefully
Hydrochlorothiazide (Microzide) AE
Low Na, K, Cl, Hypotension, Dehydration, Hyperglycemia,
Hyperuricemia (uric acid), INC in LDL/ Triglycerides, DEC in HDL, Skin photosensitivity
Hydrochlorothiazide (Microzide) DI
Digoxin
Lithium
complete Exam 4 Questions With Correct
Answers| Updated
Furosemide (Lasix) Class
Loop diuretic
Furosemide (Lasix) MOA
Acts in the thick segment of the ascending limb of the loop of Henle. Blocks reabsorption of Na/
Cl, preventing reabsorption of H2O.
Produces profound diuresis
Furosemide (Lasix) use
When rapid or massive mobilization of fluid is needed. Pulmonary edema associated with CHF,
Edema from heart, liver, or kidney that has not responded well to other drugs, HTN
Furosemide (Lasix) caution
CV disease, Renal impairment, DM, PMH of gout (can cause
,a flare-up), Pregnancy, Ototoxic drugs, NSAIDS, antihypertensives
Furosemide (Lasix) Dosing/ Admin
20, 40, 80mg tabs; IV dose available; onset within
60min ; duration 6-8hrs; usual dosage 20-80mg (1-2 times/day); start at low dose and gradually
increase
Why is Furosemide (Lasix) especially helpful for patients with renal impairment?
because diuresis can be produced even if there is a lack of renal blood flow and even when GFR
is decreased
DI for Furosemide
Digoxin (due to loss of K it can INC Digoxin levels and cause dysrhythmias), Other Ototoxic Drugs
(gentamycin) should be AVOIDED, K Sparing Diuretics (can negate the wasting some and is
sometimes combined w/ Furosemide), NSAIDS, Antihypertensive agents, Lithium
Furosemide AE
Hyponatremia
Hypokalemia
Hypochloremia
Hypotension
Dehydration
Hyperglycemia
,Hyperuricemia
INC LDL and TGs
DEC HDL
Ototoxicity**
Pt edu for furosemide
Monitor BP; S/S of ortho hypotension (rise slowly to avoid), K rich foods, s/s of dehydration
BBW for furosemide
All loop diuretics can cause profound diuresis with water and electrolyte depletion
(hypokalemia s/s: constipation, palpitations, fatigue, muscle weakness, tingling, numbness)
Hydrochlorothiazide (Microzide) drug class
Thiazide diuretic
Hydrochlorothiazide (Microzide) MOA
Acts in the early segment of the distal convoluted tubule.
Promotes urine production by blocking reabsorption of Na and Cl leading to water retention in
the nephron and increased urine flow.
More mild diuresis compared to Furosemide (Lasix)
Must have adequate GFR of at least 20mL/min
Steroid derivative
, Hydrochlorothiazide (Microzide) Use
HTN
Edema in CHF, Hepatic, or Renal disease
Hydrochlorothiazide (Microzide) Caution
CV disease, Renal impairment, DM, PMH of gout (can cause
a flare);
Meds: Digoxin, Lithium, Antihypertensive drugs
Hydrochlorothiazide (Microzide) Dosing/ Admin
12.5mg capsules; 12.5, 35, 50mg tablets; onset- 2hrs;
peaks- 4-6 hrs ;duration 6-12 hrs; usual dose- 12.5-25mg/day. Start low and adjust carefully
Hydrochlorothiazide (Microzide) AE
Low Na, K, Cl, Hypotension, Dehydration, Hyperglycemia,
Hyperuricemia (uric acid), INC in LDL/ Triglycerides, DEC in HDL, Skin photosensitivity
Hydrochlorothiazide (Microzide) DI
Digoxin
Lithium
