CHEMOTHERAPY BIOTHERAPY CERTIFICATION |
FROM PRACTICE TO PERFECTION | GUARANTEED
SUCCESS!
Resources - Answer: nccn.org
Cancer.org
LESSON 1: Cell cycle - Answer: g1- increase in size
S- dna replicated
G2- cell enlarge and ready to divide
M phase- 2 hours
Mitosis - Answer: 4 stages, prophase, metaphase, anaphase, telophase
-chemo targets certain points in the process
Apoptosis - Answer: programmed cell death
Hematopoiesis - Answer: formation of blood cells & how cells differentiate
-myeloid: pre cells mature into rbcs, platelets and wbcs
-lymphoid: pre cells- mature into WBCS
Principles of Biotherapy: p51-95 immunology - Answer: -defense against foreign
organisms, homeostasis (destroy aged cells), surveillance
Immune responses - Answer: innate: primary line of defense, non specific, no memory
Adaptive: secondary line of defence with specific memry
Cytokines - Answer: -effect growth and differentiation of WBC
-interferons, tumor necrosis factors, growth factos and interleukins
-small protein molecules released by cells throughout body providing comunication
between cells of the immune system
1
APPHIA - Crafted with Care and Precision for Academic Excellence.
,-regular antiboddy production and function of b cells
Vaccines for cancer prevention - Answer: -hep B prevents hepatitis and hepatocellular
carcinoma
-hpv vaccine
Filgrastim aka neupogen - Answer: SC or IV to derease infection in patients with
neutropenic fever associated with myelosuppressive anticancer treatments for
nonmyeloid malignancies
Tbo-filgramstim/ pegfilgrastim - Answer: reduce duration of neutroenia in patients with
non myeloid malignancies
Palifermin - Answer: IV to dec incidence of oral mucositis in patients with hem
malignanies before BMT
Sargramostim - Answer: aka leukine - patients with AML following chemo to shorten
neutrophil recovery and reduce incidence of infection
IFN gamma - Answer: reduce frequency and severity o infections related to
granulomatous disease
Aldeleukin - Answer: treat renal cell carcinoma and metastatic melanoma
Oprevelkin - Answer: prevent severe thrombocytopenia and refuce need for platelet
transfusions in patients with nonmyeloid malig
Plerixafor - Answer: with filgrastim to mobilize hematopoeitc stem cells for collection
from peripheral blood of patients
Sipuleucel - Answer: castrate resistant prostate cancer
2
APPHIA - Crafted with Care and Precision for Academic Excellence.
, Rituximab - Answer: rituxan- treatment of relapsed or refractory low grade follicular b
cell NHL_ first line traetment in combo with chemo in patients with response
-can treat severe rheumatoid arthritis
-can have severe reactions (hypotension, urticaria, angiodema, hypoxia, rigors,
dyspnea, chills, fever, nausea, rash, renal tox)
-premed with tylenol and benadryl
-slow infusion to resolve some side effects, side effects reduce with each infusion
Immune system - Answer: 1st line: skin , ucous membrane, gut flora
Second line: phagocytes:
3rd line antibodies, t and b cells
Malignant tumor (cancer) - Answer: cell strcuture different from parent tissue, cell
division uncontrolled, loosely adherent, invade neighboring tissue, establish blood
vessels
Approaches to treatment - Answer: cure: prolonged absence of disease
Control: no further growth
And palliation : comfort
Neoadjuvant - Answer: therapy in the first step to shrink a tumor before the main
treatment) surgery is given
-chemo, radiation, hormone therapy
Adjuvant - Answer: therapy given afer primary treatment to lower risk of cancer coming
back
-chemo, radiation, hormone, targeted and biologic therapy
3
APPHIA - Crafted with Care and Precision for Academic Excellence.
FROM PRACTICE TO PERFECTION | GUARANTEED
SUCCESS!
Resources - Answer: nccn.org
Cancer.org
LESSON 1: Cell cycle - Answer: g1- increase in size
S- dna replicated
G2- cell enlarge and ready to divide
M phase- 2 hours
Mitosis - Answer: 4 stages, prophase, metaphase, anaphase, telophase
-chemo targets certain points in the process
Apoptosis - Answer: programmed cell death
Hematopoiesis - Answer: formation of blood cells & how cells differentiate
-myeloid: pre cells mature into rbcs, platelets and wbcs
-lymphoid: pre cells- mature into WBCS
Principles of Biotherapy: p51-95 immunology - Answer: -defense against foreign
organisms, homeostasis (destroy aged cells), surveillance
Immune responses - Answer: innate: primary line of defense, non specific, no memory
Adaptive: secondary line of defence with specific memry
Cytokines - Answer: -effect growth and differentiation of WBC
-interferons, tumor necrosis factors, growth factos and interleukins
-small protein molecules released by cells throughout body providing comunication
between cells of the immune system
1
APPHIA - Crafted with Care and Precision for Academic Excellence.
,-regular antiboddy production and function of b cells
Vaccines for cancer prevention - Answer: -hep B prevents hepatitis and hepatocellular
carcinoma
-hpv vaccine
Filgrastim aka neupogen - Answer: SC or IV to derease infection in patients with
neutropenic fever associated with myelosuppressive anticancer treatments for
nonmyeloid malignancies
Tbo-filgramstim/ pegfilgrastim - Answer: reduce duration of neutroenia in patients with
non myeloid malignancies
Palifermin - Answer: IV to dec incidence of oral mucositis in patients with hem
malignanies before BMT
Sargramostim - Answer: aka leukine - patients with AML following chemo to shorten
neutrophil recovery and reduce incidence of infection
IFN gamma - Answer: reduce frequency and severity o infections related to
granulomatous disease
Aldeleukin - Answer: treat renal cell carcinoma and metastatic melanoma
Oprevelkin - Answer: prevent severe thrombocytopenia and refuce need for platelet
transfusions in patients with nonmyeloid malig
Plerixafor - Answer: with filgrastim to mobilize hematopoeitc stem cells for collection
from peripheral blood of patients
Sipuleucel - Answer: castrate resistant prostate cancer
2
APPHIA - Crafted with Care and Precision for Academic Excellence.
, Rituximab - Answer: rituxan- treatment of relapsed or refractory low grade follicular b
cell NHL_ first line traetment in combo with chemo in patients with response
-can treat severe rheumatoid arthritis
-can have severe reactions (hypotension, urticaria, angiodema, hypoxia, rigors,
dyspnea, chills, fever, nausea, rash, renal tox)
-premed with tylenol and benadryl
-slow infusion to resolve some side effects, side effects reduce with each infusion
Immune system - Answer: 1st line: skin , ucous membrane, gut flora
Second line: phagocytes:
3rd line antibodies, t and b cells
Malignant tumor (cancer) - Answer: cell strcuture different from parent tissue, cell
division uncontrolled, loosely adherent, invade neighboring tissue, establish blood
vessels
Approaches to treatment - Answer: cure: prolonged absence of disease
Control: no further growth
And palliation : comfort
Neoadjuvant - Answer: therapy in the first step to shrink a tumor before the main
treatment) surgery is given
-chemo, radiation, hormone therapy
Adjuvant - Answer: therapy given afer primary treatment to lower risk of cancer coming
back
-chemo, radiation, hormone, targeted and biologic therapy
3
APPHIA - Crafted with Care and Precision for Academic Excellence.
