, Chapter1:PrinciplesofPharmacology d d d d
Multiple Choice d
1. refer(s) to specific molecular changes that occur when a drug binds to a
d d d d d d d d d d d d
particular target site or receptor, while
d d aretheresultingwidespread alterations
d d d d d d d d
in function.
d d
a. Drug action; therapeutic effects
d d d
b. Side effects; drug effects
d d d
c. Therapeutic effects; side effects d d d
d. Drug action; drug effects
d d d
Answer: d d
Textbook Reference: Pharmacology: The Science of Drug Action
d d d d d d d
2. After drug administration has occurred, the amount ofdrug inthe blood that is free to bind
d d d d d d d d d d d d d d d d
at specific target sites is referred to as
d d d d d d d d
a. the therapeutic dose.
d d
b. first-pass effects. d
c. bioavailability.
d. ED50.
Answer: c d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
3. The specific molecular changes that occur when a drug binds to a particular target site or
d d d d d d d d d d d d d d d
receptor are referred to as
d d d d d
a. drug effects.d
b. drug action. d
c. side effects.
d
d. placebo effects. d
Answer: b d
Textbook Reference: Pharmacology: The Science ofDrug Action
d d d d d d d
4. Which ofthe following is not a possible explanation for placebo effects?
d d d d d d d d d d d
a. Pavlovian conditioning d
b. Genetic variation d
c. Drug competition d
d. Expectation of outcome d d
Answer: c d
Textbook Reference: Pharmacology: The Science ofDrug Action
d d d d d d d
Page 1 of 1
d d d
,5. The administration of oxytocin has been proposed as a treatment for autism. d d d d d d d d d d
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
6. Which factor does not affect the pharmacokinetics of a drug?
d d d d d d d d d
a. Route of administration
d d
b. Lipid solubility
d
c. Depot binding d
d. Drug actiond
Answer: d d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
7. First-pass metabolism occurs when drugs are taken d d d d d d
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
8. The area postrema is one area in the brain where the
d d is not complete. d d d d d d d d d d
a. cerebrospinal fluid d
b. blood–brain barrier d
c. choroid plexus d
d. phospholipid membrane d
Answer: b d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
9. First-pass metabolism occurs with orally administered drugs because
d d d d d d d
a. their absorption is slowed by food.
d d d d d
b. drugs absorbed into the bloodstream from the stomach go to the liver on the wayto
d d d d d d d d d d d d d d d
general circulation.
d d
c. drugs must first survive the acidic environment of the stomach.
d d d d d d d d d
d. salivaryenzymes in the mouth begin the process of metabolism.
d d d d d d d d d
Answer: b d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
10. Toxic substances in the blood trigger a vomiting response byactivating the
d d d d d d d d d d d
a. blood–brain barrier. d
b. choroid plexus. d
c. area postrema.
d
d. median eminence. d
Page 2 of 2
d d d
, Answer: c d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
11. Drugs administered _ have the most rapid onset of action.
d d d d d d d d
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
12. Ionization of a drug depends on the of the solution and the
d d d d d d d d d d ofthe
d
drug.
d
a. pH; pKa
d
b. pKa; pH d
c. concentration; lipid solubility d d
d. pH; concentration
d
Answer: a d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
13. The absorption of a drug depends on all of the following except
d d d d d d d d d d d
a. lipid solubility.
d
b. ionization.
c. body temperature. d
d. the concentration of the drug.
d d d d
Answer: c d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
14. Drugs that are should be avoided by women of childbearing age.
d d d d d d d d d
a. teratogenic
b. able to cross the placental barrier
d d d d d
c. psychoactive
d. highly lipid-soluble d
Answer: a d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
15. Agents that induce developmental abnormalities in a fetus are known as
d d d d d d d d d d
a. psychoactive drugs. d
b. illicit drugs. d
c. teratogens.
d. placental drugs. d
Answer: c d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
16. Depot binding is said to occur when drugs
d d d d d d d
a. bind to their target sites.
d d d d
Page 3 of 3
d d d
Multiple Choice d
1. refer(s) to specific molecular changes that occur when a drug binds to a
d d d d d d d d d d d d
particular target site or receptor, while
d d aretheresultingwidespread alterations
d d d d d d d d
in function.
d d
a. Drug action; therapeutic effects
d d d
b. Side effects; drug effects
d d d
c. Therapeutic effects; side effects d d d
d. Drug action; drug effects
d d d
Answer: d d
Textbook Reference: Pharmacology: The Science of Drug Action
d d d d d d d
2. After drug administration has occurred, the amount ofdrug inthe blood that is free to bind
d d d d d d d d d d d d d d d d
at specific target sites is referred to as
d d d d d d d d
a. the therapeutic dose.
d d
b. first-pass effects. d
c. bioavailability.
d. ED50.
Answer: c d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
3. The specific molecular changes that occur when a drug binds to a particular target site or
d d d d d d d d d d d d d d d
receptor are referred to as
d d d d d
a. drug effects.d
b. drug action. d
c. side effects.
d
d. placebo effects. d
Answer: b d
Textbook Reference: Pharmacology: The Science ofDrug Action
d d d d d d d
4. Which ofthe following is not a possible explanation for placebo effects?
d d d d d d d d d d d
a. Pavlovian conditioning d
b. Genetic variation d
c. Drug competition d
d. Expectation of outcome d d
Answer: c d
Textbook Reference: Pharmacology: The Science ofDrug Action
d d d d d d d
Page 1 of 1
d d d
,5. The administration of oxytocin has been proposed as a treatment for autism. d d d d d d d d d d
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
6. Which factor does not affect the pharmacokinetics of a drug?
d d d d d d d d d
a. Route of administration
d d
b. Lipid solubility
d
c. Depot binding d
d. Drug actiond
Answer: d d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
7. First-pass metabolism occurs when drugs are taken d d d d d d
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
8. The area postrema is one area in the brain where the
d d is not complete. d d d d d d d d d d
a. cerebrospinal fluid d
b. blood–brain barrier d
c. choroid plexus d
d. phospholipid membrane d
Answer: b d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
9. First-pass metabolism occurs with orally administered drugs because
d d d d d d d
a. their absorption is slowed by food.
d d d d d
b. drugs absorbed into the bloodstream from the stomach go to the liver on the wayto
d d d d d d d d d d d d d d d
general circulation.
d d
c. drugs must first survive the acidic environment of the stomach.
d d d d d d d d d
d. salivaryenzymes in the mouth begin the process of metabolism.
d d d d d d d d d
Answer: b d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
10. Toxic substances in the blood trigger a vomiting response byactivating the
d d d d d d d d d d d
a. blood–brain barrier. d
b. choroid plexus. d
c. area postrema.
d
d. median eminence. d
Page 2 of 2
d d d
, Answer: c d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
11. Drugs administered _ have the most rapid onset of action.
d d d d d d d d
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
12. Ionization of a drug depends on the of the solution and the
d d d d d d d d d d ofthe
d
drug.
d
a. pH; pKa
d
b. pKa; pH d
c. concentration; lipid solubility d d
d. pH; concentration
d
Answer: a d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
13. The absorption of a drug depends on all of the following except
d d d d d d d d d d d
a. lipid solubility.
d
b. ionization.
c. body temperature. d
d. the concentration of the drug.
d d d d
Answer: c d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
14. Drugs that are should be avoided by women of childbearing age.
d d d d d d d d d
a. teratogenic
b. able to cross the placental barrier
d d d d d
c. psychoactive
d. highly lipid-soluble d
Answer: a d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
15. Agents that induce developmental abnormalities in a fetus are known as
d d d d d d d d d d
a. psychoactive drugs. d
b. illicit drugs. d
c. teratogens.
d. placental drugs. d
Answer: c d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
d d d d d d
16. Depot binding is said to occur when drugs
d d d d d d d
a. bind to their target sites.
d d d d
Page 3 of 3
d d d
