Neurobiology Exam 3 Review QUESTIONS WITH ANSWERS

Neurobiology Exam 3 Review QUESTIONS |\ |\ |\ |\ |\




WITH ANSWERS |\




Which of the following is NOT a reason that Aplysia made a good
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model organism for Eric Kandel's studies of learning and memory
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in the early 1960's?
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a) Their genomes had been sequenced and their behaviors had
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been studied extensively in the past
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b) As invertebrates, their nervous systems were relatively simple
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and consisted of very large neurons
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c) They exhibited a number of behaviors which can be modified
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by experience.
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d) None of the above - CORRECT ANSWERS ✔✔a) Their genomes
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had been sequenced and their behaviors had been studied
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extensively in the past |\ |\ |\




The gill withdrawal reflex of Aplysia...
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a) Can only be studied in intact animals
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b) Involves the quick escape of Aplysia due to a water jet from its
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gills
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,c) describes the withdrawal of the gill after the animals siphon is
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touched


d) is less pronounced after sensitization - CORRECT ANSWERS
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✔✔c) describes the withdrawal of the gill after the animals siphon
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is touched
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Habituation of the gill withdrawal reflex... |\ |\ |\ |\ |\




a) is a decrease in the expression of the reflex over time caused
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by repetitive non-noxious stimuli
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b) is a decrease in the expression of the reflex over time caused
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by repetitive noxious stimuli
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c) is an increase in the expression of the reflex over time caused
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by repetitive non-noxious stimuli
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d) is an increase in the expression of the reflex over time caused
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by repetitive noxious stimuli - CORRECT ANSWERS ✔✔a) is a
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decrease in the expression of the reflex over time caused by
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repetitive non-noxious stimuli |\ |\




What was the role of the serotoninergic interneuron in the gill
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withdrawal reflex? |\

,a) the interneuron had to be present for the reflex to occur but
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was not necessary for sensitazation
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b) the interneuron received information from the siphon sensory
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neuron (and NOT the nociceptive neuron on the tail) and
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transmitted this directly to the motor neuron via a chemical
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synapse


c) the interneuron was necessary for sensitization to occur but
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was not necessary for the reflex itself
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d) The interneuron was inhibited by tail shocks
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e) The interneuron was not involved with the reflex nor its
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sensitization - CORRECT ANSWERS ✔✔c) the interneuron was
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necessary for sensitization to occur but was not necessary for the
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reflex itself
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How could one block long-term sensitization of the gill-withdrawal
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response (as opposed to short-term sensitization?)
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a) block CREB activation in the serotonin interneuron
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b) block CREB activation in the sensory neuron
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c) block PKA activation in the motor neuron
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, d) block PKA activation in the sensory neuron - CORRECT
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ANSWERS ✔✔b) block CREB activation in the sensory neuron |\ |\ |\ |\ |\ |\ |\ |\




Place the following events in the order that they occur during
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long term sensitization of the gill-withdrawal reflex:
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a) CREB binds binds to DNA containing CRE sequences and
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immediate early genes are transcribed |\ |\ |\ |\




b) CREB becomes phosphorylated
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c) adenylate cyclase activity increases
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d) cAMP levels begin to increase
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e) Serotonin binds to a G-Protein coupled receptor (GPCR; 5-
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HTR2/ 5-HTR4,6,7 - like) |\ |\ |\




f) PKA becomes activated - CORRECT ANSWERS ✔✔e --> c --> d
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--> f --> b --> a
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neuron A innervates neuron B via a chemical synapse. If neuron
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A is repeatedly stimulated (using tetanic stimulation), after a
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brief period of time the response of neuron B to a single
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stimulation will be increased at that synapse. This would be an|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\


example of homosynaptic plasticity. |\ |\ |\