NR 565 PHARM MIDTERM EXAM
QUESTIONS & VERIFIED CORRECT
ANSWERS
CYP2D6 - correct answer ✔✔Need to increase doses of SSRI, beta blockers etc.
Codeine can be deadly
CYP2C9 - correct answer ✔✔Decrease warfarin dose
Test for gene VCORC1 mutation
CYP3A4 - correct answer ✔✔Decreases elimination
Increase toxicity of Amio
Schedule I - correct answer ✔✔no accepted medical use in the US it may not be prescribed.
heroin,various opium derivatives,hallucinogenic substances
Schedule II - correct answer ✔✔No refills, no telephone orders
Narcotics, Stimulants, Depressants
Schedule III - correct answer ✔✔Drugs in this category are considered to be at moderate or low
risk for physical dependence, and with current reasons for medical use
Anabolic steroids, most barbituates and ketamine
Must prescribe every 6 months, can be by phone
, Schedule IV - correct answer ✔✔Abuse potential exists, but less than Sch III. Examples are:
Ambien, Darvocet and Lorazepam
Schedule V - correct answer ✔✔Not always necessary to have a prescription
Loperamide, diphenoxylate and cough medicine with less than 200mg/100 ml pregabalin
Preclinical research - correct answer ✔✔Research of drug potential, animal testing, preparation
for human testing
Phase I - correct answer ✔✔Initial clinical safety studies in humans. May be as few as 10
subjects, often healthy volunteers
Phase II - correct answer ✔✔The study drug or treatment is given to a larger group of people
(100-300) to see if it is effective and to further evaluate its safety
Phase III - correct answer ✔✔The study drug or treatment is given to large groups of people
(1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used
treatments, and collect information that will allow the drug or treatment to be used safely
Phase IV - correct answer ✔✔A study conducted after a drug has been shown to work and has
been granted a license (post-marketing surveillance study)
Adrenergic agonists - correct answer ✔✔Drugs that stimulate and mimic the actions of the
sympathetic nervous system. Also called sympathomimetics.
alpha 2 agonists - correct answer ✔✔Decrease sympathetic impulses from the CNS to the heart
and arterioles, causing vasodilation
Lowers blood pressure, diuretic may be needed
QUESTIONS & VERIFIED CORRECT
ANSWERS
CYP2D6 - correct answer ✔✔Need to increase doses of SSRI, beta blockers etc.
Codeine can be deadly
CYP2C9 - correct answer ✔✔Decrease warfarin dose
Test for gene VCORC1 mutation
CYP3A4 - correct answer ✔✔Decreases elimination
Increase toxicity of Amio
Schedule I - correct answer ✔✔no accepted medical use in the US it may not be prescribed.
heroin,various opium derivatives,hallucinogenic substances
Schedule II - correct answer ✔✔No refills, no telephone orders
Narcotics, Stimulants, Depressants
Schedule III - correct answer ✔✔Drugs in this category are considered to be at moderate or low
risk for physical dependence, and with current reasons for medical use
Anabolic steroids, most barbituates and ketamine
Must prescribe every 6 months, can be by phone
, Schedule IV - correct answer ✔✔Abuse potential exists, but less than Sch III. Examples are:
Ambien, Darvocet and Lorazepam
Schedule V - correct answer ✔✔Not always necessary to have a prescription
Loperamide, diphenoxylate and cough medicine with less than 200mg/100 ml pregabalin
Preclinical research - correct answer ✔✔Research of drug potential, animal testing, preparation
for human testing
Phase I - correct answer ✔✔Initial clinical safety studies in humans. May be as few as 10
subjects, often healthy volunteers
Phase II - correct answer ✔✔The study drug or treatment is given to a larger group of people
(100-300) to see if it is effective and to further evaluate its safety
Phase III - correct answer ✔✔The study drug or treatment is given to large groups of people
(1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used
treatments, and collect information that will allow the drug or treatment to be used safely
Phase IV - correct answer ✔✔A study conducted after a drug has been shown to work and has
been granted a license (post-marketing surveillance study)
Adrenergic agonists - correct answer ✔✔Drugs that stimulate and mimic the actions of the
sympathetic nervous system. Also called sympathomimetics.
alpha 2 agonists - correct answer ✔✔Decrease sympathetic impulses from the CNS to the heart
and arterioles, causing vasodilation
Lowers blood pressure, diuretic may be needed
