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Exam (elaborations)
MRCP Part 1: Hematology Exam Questions and answers
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MRCP Part 1: Hematology Exam Questions and answers Beta Thalassaemia Major - absence of beta globulin chains - chromosome 11 Features of Beta Thalassaemia Major - presents in the first year of life with failure to thrive + hepatosplenomegaly - HbA2 & HbF raised - HbA Absent Mx: repeated transfusion Hereditary Spherocytosis - most common hereditary haemolytic anaemia in Europeans - autosomal dominant - defect of red blood cell cytoskeleton - biconcave disc becomes sphere-shaped (SPHEROCYTES) - red blood cell survival reduced as destroyed by the spleen
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