PATH370 Chapter 11 QUESTIONS WITH CORRECT
ANSWERS
Enlarged, painless lymph nodes (lymphadenopathy)
Enlarged spleen
Acute Lymphoblastic Leukemia/Lymphoma
Pathogenesis and Clinical Manifestations✔✔Malignant disorder of lymphoid cell lineage
80% result of malignant transformation of B cells; 20% involve T cells
Abnormal cells are lymphoblasts: they look like immature lymphocytes
Lymphoblastic neoplasms: presents as leukemia, but lymphoblastic lymphomas are the same
disease just at a different stage
ALL primarily a children's disorder: most common malignancy, 2nd leading cause of death for
this population
Peak incidence: between 3 and 7 years; 2nd peak: middle age
Hairy Cell Leukemia
Pathogenesis and Clinical Manifestations✔✔Rare, chronic type of leukemia
2% of adult leukemia but highly treatable
Median age of presentation: 55 years; 5:1 predominance of males
B-cell phenotype
Peculiar cells with hairlike projections on their surface
Plasma Cell Myeloma (Multiple Myeloma)
Pathogenesis and Clinical Manifestations✔✔Also known as multiple myeloma
Malignant disorder of mature, antibodysecreting B lymphocytes (plasma cells)
, Occurs exclusively in adults; usually >40 years; median age 65 years
Men > women
Malignant plasma cells invade bone and form multiple tumor sites
Classification of Hematologic Neoplasms by cell type✔✔Myeloid lineage: red blood cells,
platelets, monocytes, and granulocytes
Lymphoid lineage: B cells, T cells, and natural killer (NK) cells
Myeloid neoplasms✔✔Myeloproliferative diseases Myelodysplastic/proliferative diseases
Myelodysplastic syndromes
Acute myeloid leukemia (AML)
Leukopenia✔✔Lymphadenopathy
Joint swelling and pain
Weight loss
Anorexia
Hepatomegaly
Splenomegaly
Anemia✔✔Pallor
Fatigue
Malaise
Shortness of breath
Decreased activity tolerance
✔✔Platelet count below 20,000 cells/μl
ANSWERS
Enlarged, painless lymph nodes (lymphadenopathy)
Enlarged spleen
Acute Lymphoblastic Leukemia/Lymphoma
Pathogenesis and Clinical Manifestations✔✔Malignant disorder of lymphoid cell lineage
80% result of malignant transformation of B cells; 20% involve T cells
Abnormal cells are lymphoblasts: they look like immature lymphocytes
Lymphoblastic neoplasms: presents as leukemia, but lymphoblastic lymphomas are the same
disease just at a different stage
ALL primarily a children's disorder: most common malignancy, 2nd leading cause of death for
this population
Peak incidence: between 3 and 7 years; 2nd peak: middle age
Hairy Cell Leukemia
Pathogenesis and Clinical Manifestations✔✔Rare, chronic type of leukemia
2% of adult leukemia but highly treatable
Median age of presentation: 55 years; 5:1 predominance of males
B-cell phenotype
Peculiar cells with hairlike projections on their surface
Plasma Cell Myeloma (Multiple Myeloma)
Pathogenesis and Clinical Manifestations✔✔Also known as multiple myeloma
Malignant disorder of mature, antibodysecreting B lymphocytes (plasma cells)
, Occurs exclusively in adults; usually >40 years; median age 65 years
Men > women
Malignant plasma cells invade bone and form multiple tumor sites
Classification of Hematologic Neoplasms by cell type✔✔Myeloid lineage: red blood cells,
platelets, monocytes, and granulocytes
Lymphoid lineage: B cells, T cells, and natural killer (NK) cells
Myeloid neoplasms✔✔Myeloproliferative diseases Myelodysplastic/proliferative diseases
Myelodysplastic syndromes
Acute myeloid leukemia (AML)
Leukopenia✔✔Lymphadenopathy
Joint swelling and pain
Weight loss
Anorexia
Hepatomegaly
Splenomegaly
Anemia✔✔Pallor
Fatigue
Malaise
Shortness of breath
Decreased activity tolerance
✔✔Platelet count below 20,000 cells/μl
