ONS CHEMOTHERAPY IMMUNOTHERAPY CERTIFICATE EXAM QUESTION WITH CORRECTONS CHEMOTHERAPY IMMUNOTHERAPY CERTIFICATE EXAM QUESTION WITH CORRECT

ONS CHEMOTHERAPY IMMUNOTHERAPY CERTIFICATE
EXAM QUESTION WITH CORRECT ANSWERS RATED A+
3TmajorTphasesTofTcellTdivision:T-TCORRECTTANSWERSInterphase

MitoticTphase

Cytokinesis



3TstepsTofTinterphase:T-TCORRECTTANSWERSFirstTgrowthTphaseT(G1)

SynthesisTphaseT(STphase)

SecondTgrowthTphaseT(G2)



4TphasesTofTmitosis:T-TCORRECTTANSWERSProphase

Metaphase

Anaphase

Telophase



InnateTimmunity:T-TCORRECTTANSWERSNon-specificTresponse,Teither:

1.TBarrierT(skin,TmucousTmembranes,TfloraTofTskin/gut)

2.TCellularTcomponentsT(phagocytes,TnaturalTkillerTcells,Tgranulocytes,Tmacrophages)



AdaptiveTimmunity:T-
TCORRECTTANSWERSFollowsTinnateTimmunityTifTunsuccessful.TMemoryTimmunity,Tincluding:



1.THumoralTimmunityT(productionTofTantibodiesTorTimmunoglobulins)

2.TCellTmediatedTimmunityT(dependentTuponTTTcells)

3.TRegulatoryTTT-cellsT(preventTautoimmuneTreactionsTandTlimitTinflammatoryTresponses)



DefineTmutationsT-TCORRECTTANSWERSVariationsTinTtheTnucleotideTsequenceTofTaTgene

,3TmainTgoalsTofTtreatment:T-TCORRECTTANSWERSCure

Control

Palliation



DefineTneoadjuvantTtherapyT-
TCORRECTTANSWERSTreatmentTisTgivenTpriorTtoTsurgeryTtoTshrinkTtheTtumor




DefineTadjuvantTtherapyT-
TCORRECTTANSWERSAdditionalTcancerTtreatmentTgivenTafterTtheTprimaryTtreatmentTtoTlowerTtheT


riskTthatTtheTcancerTreoccur



DefineTconditioning/preparativeTtherapyT-
TCORRECTTANSWERSTreatmentsTusedTtoTprepareTaTpatientTforTstemTcellTtransplantation




2TtypesTofTconditioningTtherapies:T-TCORRECTTANSWERSMyeloablative

Nonmyeloablative



DefineTdoseTdensityT-TCORRECTTANSWERSDrugTdoseTperTunitTofTtime



DefineTdoseTintensityT-TCORRECTTANSWERSAmountTofTdrugTdeliveredToverTtime



HowTisTrelativeTdoseTintensityT(RDI)Tcalculated?T-
TCORRECTTANSWERSByTcomparingTtheTdoseTthatTtheTpatientTACTUALLYTreceivedTtoTtheTplannedTd


oseTofTtheTstandardTregimen

, HowTdoTalkylatingTagentsTwork?T-
TCORRECTTANSWERSByTcausingTaTbreakTinTtheTDNAThelixTstrand,TinterferingTwithTDNATreplicationT


andTcausingTcellTdeath



3TsubcategoriesTofTalkylatingTagents:T-TCORRECTTANSWERS1.TNitrogenTmustards

2.TPlatinum-
basedTagentsT(doTnotTpossessTanTalkylTgroupTbutTstillTtermedTalkylatingTagentsTasTtheyTworkTsimila
rly)

3.TNitrosoureas



MostTcommonTsubcategoryTofTalkylatingTagents:T-TCORRECTTANSWERSNitrogenTmustards



CommonTalkylatingTagents:T-TCORRECTTANSWERSCyclophosphamideT(Cytoxan)

IfosfamideT(Ifex)

BendamustineT(Treanda)



CommonTplatinum-basedTagents:T-TCORRECTTANSWERSCisplatinT(Platinol)

CarboplatinT(Paraplatin)



WhatTisTuniqueTaboutTnitrosoureasTagents?T-TCORRECTTANSWERSAbleTtoTcrossTtheTblood-
brainTbarrier;TcanTbeTeffectiveTinTtreatingTsomeTbrainTtumors



CommonTnitrosoureasTagents:T-TCORRECTTANSWERSCarmustineT(BiCNU)

LomustineT(CeeNu)

StreptozocinT(Zanosar)



HypersensitivityTcanToccurTwithTlateTdosesTof:T-TCORRECTTANSWERSCarboplatin