TABLE OF CONTENT
mj mj
Chapterm j 1:m j Pharmacokinetics
Chaptermj2:mjDrug–
ReceptormjInteractionsmjandmjPharmacodynamicsm j Chaptermj3:m j Th
em j AutonomicmjNervousmjSystem
Chaptermj4:mjCholinergicmjAgonistsmj
Chaptermj5:mjCholinergicmjAntagonist
smjChaptermj6:mjAdrenergicmjAgonistsm
jChaptermj7: mjAdrenergic mjAntagonist
s
Chaptermj8:mjDrugsmjformjNeurodegenerativemjDiseasesmj
Chaptermj9:mjAnxiolyticmjandmjHypnoticmjDrugs
Chaptermj10:mjAntidepressantsmjChap
termj11:mjAntipsychoticmjDrugsmjChap
termj12:mjDrugsmjformjEpilepsymjChapt
ermj13:mjAnesthetics
Chapterm j 14:m j Opioids
Chaptermj15:mjDrugsmjofmjAbusemjCha
ptermj16:mjCNSmjStimulantsmjChapterm
j17:mjAntihypertensives mjChapter mj18
:mjDiuretics
Chapterm j 19:m j Heartm j Failure
Chaptermj20:mjAntiarrhythmicsmjChap
termj21:mjAntianginalmjDrugs
Chaptermj22:mjAnticoagulantsmjandmjAntiplateletmjAgents
m j Chaptermj23:mjDrugs mjformjHyperlipidemia
Chaptermj24:mjPituitarymjandmjThyroid
mjChaptermj25:mjDrugs mjformjDiabetes
Chaptermj26:mjEstrogensmjandmjAndrogensmjCha
ptermj27:mjAdrenalmjHormones
Chapterm j 28:m j Drugsm j form j Obesity
Chaptermj29:mjDrugsmjformjDisordersmjofmjthemjRespiratorymjSystemm j
Chaptermj30:mjAntihistamines
Chaptermj31:mjGastrointestinalmjandmjAntiemeticmjDrugsm
jChaptermj32:mjDrugs mjformjUrologicm j Disorders
Chapterm j 33:m j Drugsm j form j Anemia
Chaptermj34:mjDrugsmjformjDermatologicmjDisordersmjCha
ptermj35:mjDrugsmjformjBonemjDisorders
Chaptermj36:mjAnti-
inflammatory,mjAntipyretic,mjandm j AnalgesicmjAgentsm j Chaptermj37:m j Princi
plesmjofm j Antimicrobialm j Therapy
Chapterm j 38:m j Cellmj Wallm j Inhibitors
Chapterm j 39:m j Proteinm j Synthesism j Inhibitors
Chaptermj40:mjQuinolones,mjFolicmjAcidm j Antagonists,m j andm j Urinarym j TractmjAntisepticsmj
Chaptermj41:mjAntimycobacterialmjDrugs
Chaptermj42:mjAntifungalmjDrugsmjCh
aptermj43:mjAntiprotozoalmjDrugsmjCh
aptermj44:mjAnthelminticmjDrugsmjCha
ptermj45:mjAntiviralmjDrugs
Chapterm j 46:m j Anticancerm j Drugs
Chaptermj47:mjImmunosuppressantsmj
Chapter 48: Clinical Toxicology
,
,
, 3. The nurse is teaching a patient who will be discharged home with a prescription for an enter
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
ic- coated tablet. Which statement by the patient indicates understanding of the teaching?
mj mj mj mj mj mj mj m j mj mj mj mj
a. I may crush the tablet and put it in applesauce to improve absorption.
mj mj mj mj mj mj mj mj mj mj mj mj
b. I should consume acidic foods to enhance absorption of this medication.
mj mj mj mj mj mj mj mj mj mj
c. I should expect a delay in onset of the drugs effects after taking the tablet.
mj mj mj mj mj mj mj mj mj mj mj mj mj mj
d. I should take this medication with high-
mj mj mj mj mj mj
fat foods to improve its action. ANS: C
mj mj mj mj mj mj mj
Enteric-
coated tablets resist disintegration in the acidic environment of the stomach and disintegrate
mj mj mj mj mj mj mj mj mj mj mj mj mj
when they reach the small intestine. There is usually some delay in onset of actions after taki
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
ng these medications. Enteric-
mj mj mj
coated tablets should not be crushed or chewed, which would alter the time and location of a
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
bsorption. Acidic foods will not enhance the absorption of the medication. The patient should
mj mj mj mj mj mj mj mj mj mj mj mj mj
not to eat high-fat food before ingesting an enteric-coated tablet, because high-
mj mj mj mj mj mj mj mj mj mj mj mj
fat foods decrease the absorption rate.
mj mj mj mj mj
DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 3
mj mj mj mj mj mj mj mj
TOP: NURSING PROCESS: Nursing Intervention
mj mj mj mj
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
mj mj mj mj mj mj mj
4. A patient who is newly diagnosed with type 1 diabetes mellitus asks why insulin must b
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
e given by subcutaneous injection instead of by mouth. The nurse will explain that this is bec
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
ause
a. absorption is diminished by the first-pass effects in the liver.
mj mj mj mj mj mj mj mj mj
b. absorption is faster when insulin is given subcutaneously.
mj mj mj mj mj mj mj
c. digestive enzymes in the gastrointestinal tract prevent absorption.
mj mj mj mj mj mj mj
d. the oral form is less predictable with more adverse effect
mj mj mj mj mj mj mj mj mj
s. ANS: C
mj mj
Insulin, growth hormones, and other protein-
mj mj mj mj mj
based drugs are destroyed in the small intestine by digestive enzymes and must be given pare
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
nterally. Because insulin is destroyed by digestive enzymes, it would not make it to the liver
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
for metabolism with a first-
mj mj mj mj
pass effect. Subcutaneous tissue has fewer blood vessels, so absorption is slower in such tissu
mj mj mj mj mj mj mj mj mj mj mj mj mj mj
e. Insulin is given subcutaneously because it is desirable to have it absorb slowly.
mj mj mj mj mj mj mj mj mj mj mj mj mj
DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 3
mj mj mj mj mj mj mj mj
Pagem j 2m j ofm j 507
mj mj
Chapterm j 1:m j Pharmacokinetics
Chaptermj2:mjDrug–
ReceptormjInteractionsmjandmjPharmacodynamicsm j Chaptermj3:m j Th
em j AutonomicmjNervousmjSystem
Chaptermj4:mjCholinergicmjAgonistsmj
Chaptermj5:mjCholinergicmjAntagonist
smjChaptermj6:mjAdrenergicmjAgonistsm
jChaptermj7: mjAdrenergic mjAntagonist
s
Chaptermj8:mjDrugsmjformjNeurodegenerativemjDiseasesmj
Chaptermj9:mjAnxiolyticmjandmjHypnoticmjDrugs
Chaptermj10:mjAntidepressantsmjChap
termj11:mjAntipsychoticmjDrugsmjChap
termj12:mjDrugsmjformjEpilepsymjChapt
ermj13:mjAnesthetics
Chapterm j 14:m j Opioids
Chaptermj15:mjDrugsmjofmjAbusemjCha
ptermj16:mjCNSmjStimulantsmjChapterm
j17:mjAntihypertensives mjChapter mj18
:mjDiuretics
Chapterm j 19:m j Heartm j Failure
Chaptermj20:mjAntiarrhythmicsmjChap
termj21:mjAntianginalmjDrugs
Chaptermj22:mjAnticoagulantsmjandmjAntiplateletmjAgents
m j Chaptermj23:mjDrugs mjformjHyperlipidemia
Chaptermj24:mjPituitarymjandmjThyroid
mjChaptermj25:mjDrugs mjformjDiabetes
Chaptermj26:mjEstrogensmjandmjAndrogensmjCha
ptermj27:mjAdrenalmjHormones
Chapterm j 28:m j Drugsm j form j Obesity
Chaptermj29:mjDrugsmjformjDisordersmjofmjthemjRespiratorymjSystemm j
Chaptermj30:mjAntihistamines
Chaptermj31:mjGastrointestinalmjandmjAntiemeticmjDrugsm
jChaptermj32:mjDrugs mjformjUrologicm j Disorders
Chapterm j 33:m j Drugsm j form j Anemia
Chaptermj34:mjDrugsmjformjDermatologicmjDisordersmjCha
ptermj35:mjDrugsmjformjBonemjDisorders
Chaptermj36:mjAnti-
inflammatory,mjAntipyretic,mjandm j AnalgesicmjAgentsm j Chaptermj37:m j Princi
plesmjofm j Antimicrobialm j Therapy
Chapterm j 38:m j Cellmj Wallm j Inhibitors
Chapterm j 39:m j Proteinm j Synthesism j Inhibitors
Chaptermj40:mjQuinolones,mjFolicmjAcidm j Antagonists,m j andm j Urinarym j TractmjAntisepticsmj
Chaptermj41:mjAntimycobacterialmjDrugs
Chaptermj42:mjAntifungalmjDrugsmjCh
aptermj43:mjAntiprotozoalmjDrugsmjCh
aptermj44:mjAnthelminticmjDrugsmjCha
ptermj45:mjAntiviralmjDrugs
Chapterm j 46:m j Anticancerm j Drugs
Chaptermj47:mjImmunosuppressantsmj
Chapter 48: Clinical Toxicology
,
,
, 3. The nurse is teaching a patient who will be discharged home with a prescription for an enter
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
ic- coated tablet. Which statement by the patient indicates understanding of the teaching?
mj mj mj mj mj mj mj m j mj mj mj mj
a. I may crush the tablet and put it in applesauce to improve absorption.
mj mj mj mj mj mj mj mj mj mj mj mj
b. I should consume acidic foods to enhance absorption of this medication.
mj mj mj mj mj mj mj mj mj mj
c. I should expect a delay in onset of the drugs effects after taking the tablet.
mj mj mj mj mj mj mj mj mj mj mj mj mj mj
d. I should take this medication with high-
mj mj mj mj mj mj
fat foods to improve its action. ANS: C
mj mj mj mj mj mj mj
Enteric-
coated tablets resist disintegration in the acidic environment of the stomach and disintegrate
mj mj mj mj mj mj mj mj mj mj mj mj mj
when they reach the small intestine. There is usually some delay in onset of actions after taki
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
ng these medications. Enteric-
mj mj mj
coated tablets should not be crushed or chewed, which would alter the time and location of a
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
bsorption. Acidic foods will not enhance the absorption of the medication. The patient should
mj mj mj mj mj mj mj mj mj mj mj mj mj
not to eat high-fat food before ingesting an enteric-coated tablet, because high-
mj mj mj mj mj mj mj mj mj mj mj mj
fat foods decrease the absorption rate.
mj mj mj mj mj
DIF: COGNITIVE LEVEL: Applying (Application) REF: dm 3
mj mj mj mj mj mj mj mj
TOP: NURSING PROCESS: Nursing Intervention
mj mj mj mj
MSC: NCLEX: Physiological Integrity: Pharmacological and Parenteral Therapies
mj mj mj mj mj mj mj
4. A patient who is newly diagnosed with type 1 diabetes mellitus asks why insulin must b
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
e given by subcutaneous injection instead of by mouth. The nurse will explain that this is bec
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
ause
a. absorption is diminished by the first-pass effects in the liver.
mj mj mj mj mj mj mj mj mj
b. absorption is faster when insulin is given subcutaneously.
mj mj mj mj mj mj mj
c. digestive enzymes in the gastrointestinal tract prevent absorption.
mj mj mj mj mj mj mj
d. the oral form is less predictable with more adverse effect
mj mj mj mj mj mj mj mj mj
s. ANS: C
mj mj
Insulin, growth hormones, and other protein-
mj mj mj mj mj
based drugs are destroyed in the small intestine by digestive enzymes and must be given pare
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
nterally. Because insulin is destroyed by digestive enzymes, it would not make it to the liver
mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj mj
for metabolism with a first-
mj mj mj mj
pass effect. Subcutaneous tissue has fewer blood vessels, so absorption is slower in such tissu
mj mj mj mj mj mj mj mj mj mj mj mj mj mj
e. Insulin is given subcutaneously because it is desirable to have it absorb slowly.
mj mj mj mj mj mj mj mj mj mj mj mj mj
DIF: COGNITIVE LEVEL: Understanding (Comprehension) REF: dm 3
mj mj mj mj mj mj mj mj
Pagem j 2m j ofm j 507