Endocrinology - Pituitary Disorders
1. Where is the pituitary gland located?: - in the sella turcica of the sphenoid bone
2. How is the pituitary gland linked to the hypothalamus?: - through the pituitary (hy-
pophysial) stalk
3. What is the function of the anterior pituitary (adenohypophysis) and what is
it composed of?: - composed of glandular tissue
- produces and secretes several key hormones (ACTH, TSH, GH, LH, FSH, prolactin)
4. What is the function of the posterior pituitary (neurohypophysis) and what is
it composed of?: - composed of neural tissue
- stores and releases hormones produced by the hypothalamus (ADH, oxytocin)
5. What is the pars intermedia?: - thin, relatively avascular zone between the anterior and posterior
lobes
- poorly developed in humans
,6. What does TRH stimulate the release of?: - stimulates the release of TSH from the anterior
pituitary
7. What does CRH stimulate the release of?: - stimulates release of ACTH from the anterior pituitary
8. What does GHRH stimulate the release of?: - stimulates the release of GH from the anterior
pituitary
9. What does GHIH/Somatostatin stimulate the release of?: - inhibits the release of GH
AND Prolactin from the anterior pituitary
10. What does GnRH stimulate the release of?: - stimulates the release of LH and FSH from the
anterior pituitary
11. What does prolactin inhibitory hormone (PIH)/Dopamine stimulate the re-
lease of?: - inhibits the secretion of Prolactin
12. What are the only 2 hormones that directly target the end organ?: - GH and
Prolactin
, 13. How is hypopituitarism classified as?: Isolated pituitary deficiency
- defiicency of a single pituitary hormone
Multiple pituitary hormone deficiency
- deficiency of two or more pitutiary hormones
1. Where is the pituitary gland located?: - in the sella turcica of the sphenoid bone
2. How is the pituitary gland linked to the hypothalamus?: - through the pituitary (hy-
pophysial) stalk
3. What is the function of the anterior pituitary (adenohypophysis) and what is
it composed of?: - composed of glandular tissue
- produces and secretes several key hormones (ACTH, TSH, GH, LH, FSH, prolactin)
4. What is the function of the posterior pituitary (neurohypophysis) and what is
it composed of?: - composed of neural tissue
- stores and releases hormones produced by the hypothalamus (ADH, oxytocin)
5. What is the pars intermedia?: - thin, relatively avascular zone between the anterior and posterior
lobes
- poorly developed in humans
,6. What does TRH stimulate the release of?: - stimulates the release of TSH from the anterior
pituitary
7. What does CRH stimulate the release of?: - stimulates release of ACTH from the anterior pituitary
8. What does GHRH stimulate the release of?: - stimulates the release of GH from the anterior
pituitary
9. What does GHIH/Somatostatin stimulate the release of?: - inhibits the release of GH
AND Prolactin from the anterior pituitary
10. What does GnRH stimulate the release of?: - stimulates the release of LH and FSH from the
anterior pituitary
11. What does prolactin inhibitory hormone (PIH)/Dopamine stimulate the re-
lease of?: - inhibits the secretion of Prolactin
12. What are the only 2 hormones that directly target the end organ?: - GH and
Prolactin
, 13. How is hypopituitarism classified as?: Isolated pituitary deficiency
- defiicency of a single pituitary hormone
Multiple pituitary hormone deficiency
- deficiency of two or more pitutiary hormones