Endocrine –UW
1. 163
which antilipid drug increases TG: bile salt binding resins-increases TG synthesis in liver
2. common MOA of Niacine,febofibrtates,fish oil: all reduces VLDL
3. fish oil mainly reduces which lipid: TG
4. muscle toxicity which antilipid drugs 2: statin
fenofibrates
5. hepatotoxicity with which antilipid drugs: statin
ezetamibe
niacin
6. familial hyprcholsterolemia due to which defect: reduce LDL uptake by liver dueto R mutation
7. drug treatment for intertility due to hypogonadotrophic hypoginadism
method of adminstration
ovulation occur within: GnRh infusion in pulsatile manner
10-20 days
8. what is the mOA of leuprolide: GnRH agonist
,9. leuprolide use in which CA
adminstering method
action: prostate CA
continous infusion
intially increases testos,and DHT>then reduces the levels
10. prostate Ca groath mainly dependent on which hormones: androgens
11. what cinverts Testosterone to DHT: 5 alpha reductase
12. finesteride MOA: inhibits 5 alpha reductase
reduce DHT
normal tesotsterone
13. fenesteride use: benign prostate hyperplasia
14. which hormone afftect BPH vs prostate Ca: BPH-DHT
prostate Ca-testosterone
15. most common type of pituitary adenoma: prolactinoma
16. proloactinoma presentation in M vs F: M-hypogonadism(low libido,impotense),infertility
F-manorrhea ,galactorrhea
17. prolactine effect on GnRH,LH,tesosterone: all low
,18. which hormone tes is usd to detect menopause: FSH-high
19. why FSH high in menopause: resistant follicle
no inhibin to inhibit FSH
20. What happens to estrogen and progestron elevels in menopause: both low
21. which estrogen is formed in ovaries: estradiol
22. estrone is formed where: peripheral tissue(adipose)
23. estriol formed wherer: placenta
24. how long should a female have no menses to consider menopause: >12 mnths
25. inhibin is synthesised by which cells F,M: F-granulosa cells
M-sertoli cells
26. inhibin secretion stimulated by which hormone: FSH
27. action of inhibin: inhibit FSH
28. what inhibits LH in neg feed back: testosterone
29. testosteron eis synthesisd by which cells: Leydig cells
stimulated by LH
30. why fractures in prolactinoma: low GnRH>low estrogen>reduce bone density>osteporo-
, sis>fracutres
31. pt presenting with lactation failure after vaginal delivery DD: Sheehan syndrome-pi-
tuitary infarction
32. whats piruitary apoplexy: bleeding in to pituitary
33. supracellar lesion with solid,cyctic and calcified (3)portions DD: craniopharyngeoma
34. craniopharyngioma arise from which cells: Remnants of Rathkes pouch
35. anterior pituitary derives from what: Rathkes pouch
36. posterior pituitary derives from what: hypothalmic neurones
37. prolactinoma premenapausal women vs post mena symptms: pre-low estrogen
sym
post-mass effects
38. GH direct effect on tissues 3: increase insulin resistance
increase fat use
increase protein syth
1. 163
which antilipid drug increases TG: bile salt binding resins-increases TG synthesis in liver
2. common MOA of Niacine,febofibrtates,fish oil: all reduces VLDL
3. fish oil mainly reduces which lipid: TG
4. muscle toxicity which antilipid drugs 2: statin
fenofibrates
5. hepatotoxicity with which antilipid drugs: statin
ezetamibe
niacin
6. familial hyprcholsterolemia due to which defect: reduce LDL uptake by liver dueto R mutation
7. drug treatment for intertility due to hypogonadotrophic hypoginadism
method of adminstration
ovulation occur within: GnRh infusion in pulsatile manner
10-20 days
8. what is the mOA of leuprolide: GnRH agonist
,9. leuprolide use in which CA
adminstering method
action: prostate CA
continous infusion
intially increases testos,and DHT>then reduces the levels
10. prostate Ca groath mainly dependent on which hormones: androgens
11. what cinverts Testosterone to DHT: 5 alpha reductase
12. finesteride MOA: inhibits 5 alpha reductase
reduce DHT
normal tesotsterone
13. fenesteride use: benign prostate hyperplasia
14. which hormone afftect BPH vs prostate Ca: BPH-DHT
prostate Ca-testosterone
15. most common type of pituitary adenoma: prolactinoma
16. proloactinoma presentation in M vs F: M-hypogonadism(low libido,impotense),infertility
F-manorrhea ,galactorrhea
17. prolactine effect on GnRH,LH,tesosterone: all low
,18. which hormone tes is usd to detect menopause: FSH-high
19. why FSH high in menopause: resistant follicle
no inhibin to inhibit FSH
20. What happens to estrogen and progestron elevels in menopause: both low
21. which estrogen is formed in ovaries: estradiol
22. estrone is formed where: peripheral tissue(adipose)
23. estriol formed wherer: placenta
24. how long should a female have no menses to consider menopause: >12 mnths
25. inhibin is synthesised by which cells F,M: F-granulosa cells
M-sertoli cells
26. inhibin secretion stimulated by which hormone: FSH
27. action of inhibin: inhibit FSH
28. what inhibits LH in neg feed back: testosterone
29. testosteron eis synthesisd by which cells: Leydig cells
stimulated by LH
30. why fractures in prolactinoma: low GnRH>low estrogen>reduce bone density>osteporo-
, sis>fracutres
31. pt presenting with lactation failure after vaginal delivery DD: Sheehan syndrome-pi-
tuitary infarction
32. whats piruitary apoplexy: bleeding in to pituitary
33. supracellar lesion with solid,cyctic and calcified (3)portions DD: craniopharyngeoma
34. craniopharyngioma arise from which cells: Remnants of Rathkes pouch
35. anterior pituitary derives from what: Rathkes pouch
36. posterior pituitary derives from what: hypothalmic neurones
37. prolactinoma premenapausal women vs post mena symptms: pre-low estrogen
sym
post-mass effects
38. GH direct effect on tissues 3: increase insulin resistance
increase fat use
increase protein syth
