CURRENT Medical Diagnosis and
Treatment 2026
65th Edition
Author(s)Maxine A. Papadakis; Michael
W. Rabow; Kenneth R. McQuaid; Paul L.
Nadler; Erika Leemann Price
TEST BANK
1)
Reference — Ch. 1 — Disease Prevention & Health Promotion
— Immunizations (Adult).
Question Stem: A 68-year-old man with well-controlled
diabetes presents for routine care. He asks which vaccine is
most important this season to reduce his risk of severe
respiratory infection. Which vaccine should you prioritize?
,A. Live attenuated intranasal influenza vaccine
B. Inactivated high-dose influenza vaccine
C. 13-valent pneumococcal conjugate vaccine only
D. Typhoid conjugate vaccine
Correct Answer: B
Rationale — Correct (B): For older adults and those with
chronic conditions, an inactivated high-dose influenza vaccine
provides improved immunogenicity and is recommended to
reduce severe influenza and complications. This aligns with
CMDT’s adult immunization emphasis on age-appropriate
influenza vaccination. accessmedicine.mhmedical.com
Rationale — A: Live intranasal influenza vaccine is
contraindicated or less preferred in older adults and those with
certain chronic conditions.
Rationale — C: Pneumococcal vaccination is important but
must be considered in schedule context (both conjugate and
polysaccharide may be indicated); it does not replace seasonal
influenza vaccine for immediate respiratory risk.
Rationale — D: Typhoid vaccine has no routine indication for
older adults in the community without travel exposure.
Teaching Point: Prioritize age-appropriate inactivated influenza
vaccination for older adults with chronic disease.
Papadakis et al. (2025). CURRENT Medical Diagnosis &
Treatment 2026 (65th Ed.). Ch. 1.
accessmedicine.mhmedical.com
,2)
Reference — Ch. 1 — Disease Prevention & Health Promotion
— Tobacco Use & Cessation.
Question Stem: A 52-year-old woman who smokes 1 pack/day
wants to quit. Which initial management strategy best balances
efficacy and safety as first-line therapy?
A. Varenicline (partial nicotinic agonist) plus behavioral
counseling
B. Bupropion and abrupt nicotine patch cessation without
counseling
C. Long-term benzodiazepine prescription to reduce withdrawal
anxiety
D. Unsupervised herbal supplements marketed for cessation
Correct Answer: A
Rationale — Correct (A): First-line pharmacotherapy combined
with behavioral counseling yields the highest quit rates;
varenicline plus counseling is recommended in CMDT as highly
effective and safe with appropriate monitoring.
accessmedicine.mhmedical.com
Rationale — B: Bupropion is effective, but pairing it with abrupt
cessation of nicotine without counseling lowers overall success;
counseling should accompany pharmacotherapy.
Rationale — C: Benzodiazepines are inappropriate due to
dependence risk and lack of efficacy for nicotine withdrawal.
Rationale — D: Herbal supplements lack consistent evidence
and are not recommended as first-line.
, Teaching Point: Combine evidence-based pharmacotherapy
with behavioral counseling for best tobacco cessation
outcomes.
Papadakis et al. (2025). CURRENT Medical Diagnosis &
Treatment 2026 (65th Ed.). Ch. 1.
accessmedicine.mhmedical.com
3)
Reference — Ch. 1 — Disease Prevention & Health Promotion
— Cancer Screening (General Principles).
Question Stem: A 55-year-old asymptomatic woman with no
family history asks about screening to reduce cancer mortality.
Which screening approach best reflects evidence-based
preventive strategy?
A. Annual chest CT for all adults >50 to screen for lung cancer
B. Shared decision-making about colorectal screening with
modality selection
C. Monthly whole-body MRI for early cancer detection
D. Omit all screening because she is asymptomatic
Correct Answer: B
Rationale — Correct (B): CMDT emphasizes evidence-based
cancer screening (eg, colorectal screening for adults 45–75) and
the importance of shared decision-making about modality
(colonoscopy, FIT). Screening should be individualized and
aligned with guideline recommendations.
Treatment 2026
65th Edition
Author(s)Maxine A. Papadakis; Michael
W. Rabow; Kenneth R. McQuaid; Paul L.
Nadler; Erika Leemann Price
TEST BANK
1)
Reference — Ch. 1 — Disease Prevention & Health Promotion
— Immunizations (Adult).
Question Stem: A 68-year-old man with well-controlled
diabetes presents for routine care. He asks which vaccine is
most important this season to reduce his risk of severe
respiratory infection. Which vaccine should you prioritize?
,A. Live attenuated intranasal influenza vaccine
B. Inactivated high-dose influenza vaccine
C. 13-valent pneumococcal conjugate vaccine only
D. Typhoid conjugate vaccine
Correct Answer: B
Rationale — Correct (B): For older adults and those with
chronic conditions, an inactivated high-dose influenza vaccine
provides improved immunogenicity and is recommended to
reduce severe influenza and complications. This aligns with
CMDT’s adult immunization emphasis on age-appropriate
influenza vaccination. accessmedicine.mhmedical.com
Rationale — A: Live intranasal influenza vaccine is
contraindicated or less preferred in older adults and those with
certain chronic conditions.
Rationale — C: Pneumococcal vaccination is important but
must be considered in schedule context (both conjugate and
polysaccharide may be indicated); it does not replace seasonal
influenza vaccine for immediate respiratory risk.
Rationale — D: Typhoid vaccine has no routine indication for
older adults in the community without travel exposure.
Teaching Point: Prioritize age-appropriate inactivated influenza
vaccination for older adults with chronic disease.
Papadakis et al. (2025). CURRENT Medical Diagnosis &
Treatment 2026 (65th Ed.). Ch. 1.
accessmedicine.mhmedical.com
,2)
Reference — Ch. 1 — Disease Prevention & Health Promotion
— Tobacco Use & Cessation.
Question Stem: A 52-year-old woman who smokes 1 pack/day
wants to quit. Which initial management strategy best balances
efficacy and safety as first-line therapy?
A. Varenicline (partial nicotinic agonist) plus behavioral
counseling
B. Bupropion and abrupt nicotine patch cessation without
counseling
C. Long-term benzodiazepine prescription to reduce withdrawal
anxiety
D. Unsupervised herbal supplements marketed for cessation
Correct Answer: A
Rationale — Correct (A): First-line pharmacotherapy combined
with behavioral counseling yields the highest quit rates;
varenicline plus counseling is recommended in CMDT as highly
effective and safe with appropriate monitoring.
accessmedicine.mhmedical.com
Rationale — B: Bupropion is effective, but pairing it with abrupt
cessation of nicotine without counseling lowers overall success;
counseling should accompany pharmacotherapy.
Rationale — C: Benzodiazepines are inappropriate due to
dependence risk and lack of efficacy for nicotine withdrawal.
Rationale — D: Herbal supplements lack consistent evidence
and are not recommended as first-line.
, Teaching Point: Combine evidence-based pharmacotherapy
with behavioral counseling for best tobacco cessation
outcomes.
Papadakis et al. (2025). CURRENT Medical Diagnosis &
Treatment 2026 (65th Ed.). Ch. 1.
accessmedicine.mhmedical.com
3)
Reference — Ch. 1 — Disease Prevention & Health Promotion
— Cancer Screening (General Principles).
Question Stem: A 55-year-old asymptomatic woman with no
family history asks about screening to reduce cancer mortality.
Which screening approach best reflects evidence-based
preventive strategy?
A. Annual chest CT for all adults >50 to screen for lung cancer
B. Shared decision-making about colorectal screening with
modality selection
C. Monthly whole-body MRI for early cancer detection
D. Omit all screening because she is asymptomatic
Correct Answer: B
Rationale — Correct (B): CMDT emphasizes evidence-based
cancer screening (eg, colorectal screening for adults 45–75) and
the importance of shared decision-making about modality
(colonoscopy, FIT). Screening should be individualized and
aligned with guideline recommendations.
