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NCOI UNIT 4 Immune system Questions and answers

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10/30/25, 4:09 PM NCOI UNIT 4 Immune system Flashcards | Quizlet



NCOI UNIT 4 Immune system
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Terms in this set (50)


Artificial Active Immunity Immunization with antigen (e.g., vaccines for chickenpox, measles, mumps)

First leukocytes to arrive at site of injury (6 - 12
hours)
Phagocytize bacteria, other foreign material, and
Neutrophils damaged cells
Short life span (24 - 48 hours)
Released from Bone marrow in response to
infection.

Second type of phagocytic cells to migrate to site
of injury from circulating blood
Attracted to the site by chemotactic factors
Arrive within 3 to 7 days after onset of
Monocytes
inflammation
On entering tissue spaces, monocytes transform
into macrophages
Assist in phagocytosis of inflammatory debris

Long lifespan
are transformed from monocytes.
Important in cleaning area before healing can
occur
May stay in damaged tissues for weeks
Cells may fuse to form multinucleated giant cell
-are often found in tissue just beneath epithelial
Macrophages
cells. These cells are activated when a pathogen
breaches a physical barrier such as the skin. They
also play a central role in the innate immune
response because they ingest pathogens and
debris, such as dead cells in tissues. They also
release cytokines, which activate other parts of the
immune response.



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, 10/30/25, 4:09 PM NCOI UNIT 4 Immune system Flashcards | Quizlet

Arrive later at the site of injury
Primary roles of these involve
Lymphocytes
-Cell-mediated immunity
-Humoral immunity

Chemotherapeutic medication used to treat Hodgkin and non-Hodgkin's lymphoma,
Cytoxan (cyclophosphamaide)- Burkitt's lymphoma, chronic lymphocytic leukemia, breast cancer, ovarian cancer,
multiple myeloma.

Tamoxifen (Nolvadex) Chemotherapeutic agent used to treat breast cancer.

Chemotherapeutic agent used to treat breast cancer, head and neck cancers, anal
Antimetabolic (5-FU)
cancer.

Chemotherapeutic agent used to treat malignant melanoma, hairy cell leukemia,
Roferon-A (alpha-2a)
chronic hepatitis C (common side effect is flu-like symptoms)

Chemotherapeutic agent used with other agents to treat breast cancer, bladder
Doxorubicin (Adriamycin) cancer, Kaposi's sarcoma, lymphoma, acute lymphocytic leukemia (cardiac
implications)

bone marrow stimulant used in patients with leukopenia, can cause severe bone
Filgrastim (Neupogen)
pain.

Vasodilation and Increased Capillary responsible for redness, heat, and swelling at the site of injury and the surrounding
permeability area.

i. Initially composed of serous fluid
ii. Later contains plasma proteins, primarily albumin
Fluid in tissue spaces
-Proteins exert oncotic pressure that further draws fluid from blood vessels
-Tissue becomes edematous

Corticosteroids, nonsteroidal anti-inflammatory
Pathway of generation of prostaglandins, drugs (NSAIDs), and acetylsalicylic acid (ASA) act
thromboxane's, and leukotrienes to inhibit various steps in this pathway.



Antibodies Immune globulins produced by lymphocytes in response to antigens

Substances, usually composed of proteins, the body recognizes as foreign that elicit
Antigens
an immune response

proteins in blood plasma that identify pathogens and activate the inflammatory
Complement system
response to an infection.

small protein molecules that play a role in all phases of the immune system; they
Cytokines
mediate the innate immune response with several functions

Part of the innate immune system and a type of lymphocyte that is activated early
Natural Killer cells
during an infection and play a key role in preventing it from spreading.

Natural contact with antigen through actual infection (e.g., chickenpox, measles,
Natural Active Immunity
mumps)

Transplacental and colostrum transfer from mother to child (e.g., maternal
Natural Passive Immunity
immunoglobulins passed to baby)

Injection of serum with antibodies from one person (e.g., injection of hepatitis B
Artificial Passive Immunity
immune globulin) to another person who does not have antibodies

Immune cells Made within the Bone Marrow

situated just in front of the heart. It is where lymphocytes mature before release into
Thymus Gland
the bloodstream.




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