UAMS HEMATOLOGY TEST PAPER QUESTIONS AND
ANSWERS GRADED A+
-
✔✔Bone Marrow - ✔✔Largest organ in the body; is defined as a tissue located within
the cavities of the cortical bones; cavities consist of trabecular bone resembling a
honeycomb-like structure
✔✔Lymph Nodes - ✔✔Encapsulated collection of lymphocytes, plasma cells, and
macrophages; helps provide immunity
✔✔Reticuloendothelial system - ✔✔Network of cells and tissues in the spleen, liver,
thymus, bone marrow, and lymph nodes. Involved in the formation and destruction of
RBCs, metabolism of iron, inflammation, and immunity. Cell and tissue specific. It
provides cells to fight infection, carry oxygen, and prevent bleeding.
✔✔Pass through germinal centers of the white pulp - ✔✔T Cells
✔✔Found inside germinal centers of white pulp - ✔✔B Cells
✔✔Percentage of platelets in the spleen - ✔✔30 %
✔✔Culling - ✔✔Cells are phagocytized with the degradation of cellular components.
✔✔Pitting - ✔✔Splenic macrophages remove inclusions or damaged surface membrane
from circulating RBCs
✔✔Spleen Sinus - ✔✔Filter lined with specialized macrophages that help remove red
cells incapable of exhibiting "deformability"
✔✔Cords - ✔✔Open passageways supported by reticular cells and lined with
macrophages
✔✔Red Marrow - ✔✔Hematopoietic active bone marrow
✔✔Yellow Marrow - ✔✔Hematopoietic inactive marrow composed of fat cells
(adipocytes)
✔✔Adult bone marrow ratio - ✔✔50:50 (fat to cell )
✔✔When does bone marrow retrogression (change) occur? - ✔✔At age 7
✔✔Primary location of red marrow in adults - ✔✔Flat bones, sternum, vertebrae, pelvis,
ribs, skull, and proximal long bones
, ✔✔Primary location of red marrow in children - ✔✔Long bones (mostly active red
marrow)
✔✔Margination - ✔✔Cells line the inside of the blood vessel and wait for inflammation
to occur
✔✔Diapedesis - ✔✔Leave the blood after a few hours and enter the tissues or cavities
✔✔How is blood supplied by the bone marrow - ✔✔Periosteal arteries that coil around
the central vein passing along the bone canal; branch and form capillaries an then
sinuses
✔✔Blood Flow (smallest to largest) - ✔✔Capillary, sinus, vein
(Capillaries hook up to larger vein returning to circulation)
✔✔Last cell to undergo mitosis - ✔✔Myelocyte
✔✔Calcified Bone - ✔✔Trabeculae
✔✔Red Marrow - ✔✔Composed of extravascular cords that contain all of the
developing blood cell lineages (stem and progenitor cells, adventitial cells, and
macrophages).
✔✔Where are cells in red marrow? - ✔✔Cords and wedges (semi-liquid form) between
sinuses which are supported by trabeculae (spongy bone) and reticular adventitial cells
✔✔Where do cells develop into specific niches? - ✔✔Cords
✔✔Where do RBCS develop within the BM? - ✔✔Adjacent to the outer surfaces of
vascular sinuses (in clusters)
✔✔Where do MEGAKARYOCYTES develop within the BM? - ✔✔Close to the vascular
walls
✔✔Where do GRANULOCYTES develop within the BM? - ✔✔Deep in the cords and
migrate closer to the vascular sinuses
✔✔Why do RBC BLASTS surround iron-laden macrophages? - ✔✔To incorporate iron
into hemoglobin
✔✔Can yellow marrow be converted to red marrow? - ✔✔Yes, in increased demand
such as hemolysis or excessive blood loss
ANSWERS GRADED A+
-
✔✔Bone Marrow - ✔✔Largest organ in the body; is defined as a tissue located within
the cavities of the cortical bones; cavities consist of trabecular bone resembling a
honeycomb-like structure
✔✔Lymph Nodes - ✔✔Encapsulated collection of lymphocytes, plasma cells, and
macrophages; helps provide immunity
✔✔Reticuloendothelial system - ✔✔Network of cells and tissues in the spleen, liver,
thymus, bone marrow, and lymph nodes. Involved in the formation and destruction of
RBCs, metabolism of iron, inflammation, and immunity. Cell and tissue specific. It
provides cells to fight infection, carry oxygen, and prevent bleeding.
✔✔Pass through germinal centers of the white pulp - ✔✔T Cells
✔✔Found inside germinal centers of white pulp - ✔✔B Cells
✔✔Percentage of platelets in the spleen - ✔✔30 %
✔✔Culling - ✔✔Cells are phagocytized with the degradation of cellular components.
✔✔Pitting - ✔✔Splenic macrophages remove inclusions or damaged surface membrane
from circulating RBCs
✔✔Spleen Sinus - ✔✔Filter lined with specialized macrophages that help remove red
cells incapable of exhibiting "deformability"
✔✔Cords - ✔✔Open passageways supported by reticular cells and lined with
macrophages
✔✔Red Marrow - ✔✔Hematopoietic active bone marrow
✔✔Yellow Marrow - ✔✔Hematopoietic inactive marrow composed of fat cells
(adipocytes)
✔✔Adult bone marrow ratio - ✔✔50:50 (fat to cell )
✔✔When does bone marrow retrogression (change) occur? - ✔✔At age 7
✔✔Primary location of red marrow in adults - ✔✔Flat bones, sternum, vertebrae, pelvis,
ribs, skull, and proximal long bones
, ✔✔Primary location of red marrow in children - ✔✔Long bones (mostly active red
marrow)
✔✔Margination - ✔✔Cells line the inside of the blood vessel and wait for inflammation
to occur
✔✔Diapedesis - ✔✔Leave the blood after a few hours and enter the tissues or cavities
✔✔How is blood supplied by the bone marrow - ✔✔Periosteal arteries that coil around
the central vein passing along the bone canal; branch and form capillaries an then
sinuses
✔✔Blood Flow (smallest to largest) - ✔✔Capillary, sinus, vein
(Capillaries hook up to larger vein returning to circulation)
✔✔Last cell to undergo mitosis - ✔✔Myelocyte
✔✔Calcified Bone - ✔✔Trabeculae
✔✔Red Marrow - ✔✔Composed of extravascular cords that contain all of the
developing blood cell lineages (stem and progenitor cells, adventitial cells, and
macrophages).
✔✔Where are cells in red marrow? - ✔✔Cords and wedges (semi-liquid form) between
sinuses which are supported by trabeculae (spongy bone) and reticular adventitial cells
✔✔Where do cells develop into specific niches? - ✔✔Cords
✔✔Where do RBCS develop within the BM? - ✔✔Adjacent to the outer surfaces of
vascular sinuses (in clusters)
✔✔Where do MEGAKARYOCYTES develop within the BM? - ✔✔Close to the vascular
walls
✔✔Where do GRANULOCYTES develop within the BM? - ✔✔Deep in the cords and
migrate closer to the vascular sinuses
✔✔Why do RBC BLASTS surround iron-laden macrophages? - ✔✔To incorporate iron
into hemoglobin
✔✔Can yellow marrow be converted to red marrow? - ✔✔Yes, in increased demand
such as hemolysis or excessive blood loss
