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Class notes

De Anza - Organic Chemistry - Nucleophiles and Electrophiles

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2025/2026 Written for academic year
Institution De Anza College
Course CHEM12A
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In class organic chemistry notes on nucleophiles and electrophiles

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nucleophiles and electrophiles

nucleophile
:
nucleus lover (lewis base)
·

molecule that donates electrons to form a bond


electrophile :
electron lover (lewis acid)
·

molecule that accepts electrons to form a bond


nucleophiles
common misconceptions
·
basicity = nucleophilicity they're correlated but , not

interchangable


"Nucleophilic center" :
electron pair that is donated

the to
the best nucleophiles are most willing
donate lone pair or it bond electrons


electrophiles
+



example incomplete octet : electron deficient



Cl dipole "makes carbon partially
St &
positive
·
electrophilic


electrophilic center :
atom that is attacked by
the nucleophile

Br
St
,
S
+

OH

great electrophile poor electrophile

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October 30, 2025
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Written in
2025/2026
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