MRCP QUESTIONS - HAEMATOLOGY COMPREHENSIVE
EXAM QUESTIONS WITH DETAILED VERIFIED AND 100%
ACCURATE ANSWERS BRAND NEW EXAM ALREADY
GRADED A+ PASS
What is Anagrelide? Ans✓✓✓It is used to control platelets in essential
thrombocythemia.
What is Asparaginase? Ans✓✓✓it is used in the treatment of acute
lymphoblastic leukaemia.
When do you do Venesection in Polycythemia vera? Ans✓✓✓should
aim to get the haematocrit below 0.45
How long should anticoagulation be continued in pregnancy? What leg
is frequently affected in DVT? Ans✓✓✓Anticoagulation should
continue until at least 6 weeks post partum in this patient. Left leg.
What are the principal features of myelodysplasia ? Ans✓✓✓B12 and
folate levels must be normal to establish the diagnosis. Blasts can be a
feature of evolving myelodysplasia
A 25-year-old man was shot in the thigh at a local restaurant and was
moribund when brought in to A&E. He received 20 units of blood to
maintain normovolaemia. His coagulation parameters were PT 23
seconds, APTT 56 seconds and thrmobin time 25 seconds. His
fibrinogen level was 0.6g/L. Which of the following results can be
predicted? Ans✓✓✓Disseminated intravascular coagulation results from
, excess thrombin generation arising from excessive tissue thromboplastin
activation of coagulation. This occurs in presence of reduced
fibrinolysis, leading to bleeding diathesis. There are low levels of
platelets (and hence a prolonged bleeding time), protein C/S,
antithrombin, factor VIII, factor VII and other coagulation factors due to
ongoing consumption and reduced synthesis. PAI type 1 levels, D-
Dimers are increased.
A 63-year-old man was admitted with fever and dyspnoea. He had been
previously well. Investigation revealed haemoglobin was 9.2 g/dL
(normal range 12-16.5), mean corpuscular volume 113 fL (normal range
80-100), white cell count 14 x 109/L (normal range 4-11) and platelets
23 x 109/L (normal range 150-400). His blood film is shown in the
image above. What is the most likely diagnosis? Ans✓✓✓Note the
clumping of red cells on the film caused by cold agglutinins, which are a
feature of Mycoplasma pneumonia
A 76-year-old man had been treated with fludarabine for Waldenström's
macroglobulinaemia 5 years ago. His IgM band had fallen from 36 g/l to
a plateau of 5 g/l. He was stable for 5 years but suddenly presented with
Hb 6.7 gm/dl, platelets 79, creatinine 130 micromol/l, plasma viscosity
2.5 mPa/sec. During blood transfusion, he developed a tachycardia and
chest pain and was transferred to CCU. The next day results showed Hb
7 g/dl, Coombs' test positive, creatinine 377 micromol/l. What is the
most likely diagnosis? Ans✓✓✓Most Waldenström's and myeloma
patients relapse with a rise in their paraprotein; this man's IgM had risen
to 29 g/l when tested and the anaemia was a feature of active disease. He
developed chest pain due to an acute haemolytic transfusion reaction,
and this caused the Coombs' test to become positive. He had developed a
Jka red cell antibody, which had not previously been detected
EXAM QUESTIONS WITH DETAILED VERIFIED AND 100%
ACCURATE ANSWERS BRAND NEW EXAM ALREADY
GRADED A+ PASS
What is Anagrelide? Ans✓✓✓It is used to control platelets in essential
thrombocythemia.
What is Asparaginase? Ans✓✓✓it is used in the treatment of acute
lymphoblastic leukaemia.
When do you do Venesection in Polycythemia vera? Ans✓✓✓should
aim to get the haematocrit below 0.45
How long should anticoagulation be continued in pregnancy? What leg
is frequently affected in DVT? Ans✓✓✓Anticoagulation should
continue until at least 6 weeks post partum in this patient. Left leg.
What are the principal features of myelodysplasia ? Ans✓✓✓B12 and
folate levels must be normal to establish the diagnosis. Blasts can be a
feature of evolving myelodysplasia
A 25-year-old man was shot in the thigh at a local restaurant and was
moribund when brought in to A&E. He received 20 units of blood to
maintain normovolaemia. His coagulation parameters were PT 23
seconds, APTT 56 seconds and thrmobin time 25 seconds. His
fibrinogen level was 0.6g/L. Which of the following results can be
predicted? Ans✓✓✓Disseminated intravascular coagulation results from
, excess thrombin generation arising from excessive tissue thromboplastin
activation of coagulation. This occurs in presence of reduced
fibrinolysis, leading to bleeding diathesis. There are low levels of
platelets (and hence a prolonged bleeding time), protein C/S,
antithrombin, factor VIII, factor VII and other coagulation factors due to
ongoing consumption and reduced synthesis. PAI type 1 levels, D-
Dimers are increased.
A 63-year-old man was admitted with fever and dyspnoea. He had been
previously well. Investigation revealed haemoglobin was 9.2 g/dL
(normal range 12-16.5), mean corpuscular volume 113 fL (normal range
80-100), white cell count 14 x 109/L (normal range 4-11) and platelets
23 x 109/L (normal range 150-400). His blood film is shown in the
image above. What is the most likely diagnosis? Ans✓✓✓Note the
clumping of red cells on the film caused by cold agglutinins, which are a
feature of Mycoplasma pneumonia
A 76-year-old man had been treated with fludarabine for Waldenström's
macroglobulinaemia 5 years ago. His IgM band had fallen from 36 g/l to
a plateau of 5 g/l. He was stable for 5 years but suddenly presented with
Hb 6.7 gm/dl, platelets 79, creatinine 130 micromol/l, plasma viscosity
2.5 mPa/sec. During blood transfusion, he developed a tachycardia and
chest pain and was transferred to CCU. The next day results showed Hb
7 g/dl, Coombs' test positive, creatinine 377 micromol/l. What is the
most likely diagnosis? Ans✓✓✓Most Waldenström's and myeloma
patients relapse with a rise in their paraprotein; this man's IgM had risen
to 29 g/l when tested and the anaemia was a feature of active disease. He
developed chest pain due to an acute haemolytic transfusion reaction,
and this caused the Coombs' test to become positive. He had developed a
Jka red cell antibody, which had not previously been detected
