ANCC AGPCNP PRACTICE EXAM 2026
QUESTIONS AND ANSWERS ALREADY
GRADED A+
⩥ A young adult presents for reassessment of uncontrolled asthma
symptoms. The patient is currently taking an inhaled short-acting beta2-
agonist (SABA) as needed and reports daytime symptoms more than 3
days/week, but not daily, and nighttime awakenings 4 to 5 times/week.
The patient's forced expiratory volume (FEV1) is 80% of predicted. The
nurse practitioner upgrades the patient to the next stage of treatment,
which includes:
a. Budesonide with formoterol
b. Budesonide with montelukast
c. Cromolyn or nedocromil
d. Fluticasone with salmeterol. Answer: a. Budesonide with formoterol.
The patient has moved from step 2 to step 3 on the asthma classification
scale. Therefore, a low-dose inhaled corticosteroid (ICS) plus long-
acting beta-agonist (LABA) such as budesonide with formoterol is an
appropriate starting point. Fluticasone with salmeterol is prescribed if
the patient is at step 4; budesonide with montelukast is an alternative.
Cromolyn and nedocromil have been discontinued in the United States.
,⩥ Which of the following drugs can increase the risk of bleeding in
patients who are receiving anticoagulation therapy with warfarin sodium
(Coumadin)?
a. Trimethoprim-sulfamethoxazole (Bactrim DS)
b. Carafate (Sucralfate)
c. Losartan (Cozaar)
d. Furosemide (Lasix). Answer: a. Trimethoprim-sulfamethoxazole
(Bactrim DS).
Warfarin sodium (Coumadin) interacts with Bactrim and will increase
the risk of bleeding; therefore, concurrent use is contraindicated.
⩥ A 22-year-old woman is going on a 5-day cruise for her honeymoon.
She reports a history of severe motion sickness. Which of the following
medicines can be prescribed for motion sickness?
a. Dimenhydrinate (Dramamine)
b. Metoclopramide (Reglan)
c. Ondansetron (Zofran)
d. Scopolamine patch (Transderm Scop). Answer: d. Scopolamine patch
(Transderm Scop)
,Scopolamine patch (Transderm Scop) is a prescription medicine that is
used for motion/sea sickness. It is a small, circular patch that is placed
behind the ear and is effective for 3 days. Advise the patient to apply it 4
hours before the trip to be effective. Because the question is asking
about a "prescribed" medication, an over-the-counter (OTC) medicine,
such as Dramamine, is an incorrect response. Zofran is indicated for
cancer-related nausea and vomiting (chemotherapy, radiation, surgery).
⩥ The nurse practitioner is completing a health assessment on a 15-year-
old female patient who is in the office for her annual physical. The
patient reports feelings of hopelessness and sadness for several months,
no history of suicidal ideations, and a struggle with anorexia. The patient
scores an 11 on Beck's Depression Inventory. Which antidepressant will
the nurse practitioner prescribe?
a. Sertraline (Zoloft)
b. Lithium carbonate (Eskalith)
c. Bupropion (Wellbutrin)
d. Escitalopram (Lexapro). Answer: d. Escitalopram [Lexapro]
Escitalopram is a safe antidepressant for an adolescent who has severe
depression and no history of suicidal ideations. Sertraline is not a safe
option for patients younger than 24 years of age because of increased
risk of suicidal ideation. Bupropion is an atypical antidepressant and is
not a first-line therapy for depression. It is contraindicated in patients
with anorexia nervosa. Lithium is indicated for patients with bipolar
disorder.
, ⩥ Which initial treatment will the nurse practitioner prescribe to a 23-
year-old female allergic to sulfa drugs who is diagnosed with acute
cystitis?
a. Cephalexin (Keflex) 500 mg BID × 5 days
b. Ciprofloxacin (Cipro) 250 mg BID × 3 days
c. Nitrofurantoin (Macrobid) 100 mg BID × 5 days
d. Amoxicillin 500 mg BID × 5 days. Answer: c. Nitrofurantoin
(Macrobid) 100 mg BID × 5 days
Nitrofurantoin can be safely administered to a patient with a sulfa
allergy to treat acute cystitis and is the first line of treatment. Cephalexin
and amoxicillin are beta-lactam antibiotics that can be prescribed for a
patient who has an allergy to sulfa and nitrofurantoin. A
fluoroquinolone, such as ciprofloxacin, is recommended for a patient
who is allergic to sulfa and beta-lactam drugs or has a sulfa allergy and a
known resistance to beta-lactam antibiotics.
⩥ A 68-year-old patient recently prescribed caridopa-levodopa (Sinemet)
tells the nurse practitioner that he has been bloated and experiencing
difficulty with bowel movements. Which medication will the nurse
practitioner consider incorporating into the treatment plan?
a. Senna
QUESTIONS AND ANSWERS ALREADY
GRADED A+
⩥ A young adult presents for reassessment of uncontrolled asthma
symptoms. The patient is currently taking an inhaled short-acting beta2-
agonist (SABA) as needed and reports daytime symptoms more than 3
days/week, but not daily, and nighttime awakenings 4 to 5 times/week.
The patient's forced expiratory volume (FEV1) is 80% of predicted. The
nurse practitioner upgrades the patient to the next stage of treatment,
which includes:
a. Budesonide with formoterol
b. Budesonide with montelukast
c. Cromolyn or nedocromil
d. Fluticasone with salmeterol. Answer: a. Budesonide with formoterol.
The patient has moved from step 2 to step 3 on the asthma classification
scale. Therefore, a low-dose inhaled corticosteroid (ICS) plus long-
acting beta-agonist (LABA) such as budesonide with formoterol is an
appropriate starting point. Fluticasone with salmeterol is prescribed if
the patient is at step 4; budesonide with montelukast is an alternative.
Cromolyn and nedocromil have been discontinued in the United States.
,⩥ Which of the following drugs can increase the risk of bleeding in
patients who are receiving anticoagulation therapy with warfarin sodium
(Coumadin)?
a. Trimethoprim-sulfamethoxazole (Bactrim DS)
b. Carafate (Sucralfate)
c. Losartan (Cozaar)
d. Furosemide (Lasix). Answer: a. Trimethoprim-sulfamethoxazole
(Bactrim DS).
Warfarin sodium (Coumadin) interacts with Bactrim and will increase
the risk of bleeding; therefore, concurrent use is contraindicated.
⩥ A 22-year-old woman is going on a 5-day cruise for her honeymoon.
She reports a history of severe motion sickness. Which of the following
medicines can be prescribed for motion sickness?
a. Dimenhydrinate (Dramamine)
b. Metoclopramide (Reglan)
c. Ondansetron (Zofran)
d. Scopolamine patch (Transderm Scop). Answer: d. Scopolamine patch
(Transderm Scop)
,Scopolamine patch (Transderm Scop) is a prescription medicine that is
used for motion/sea sickness. It is a small, circular patch that is placed
behind the ear and is effective for 3 days. Advise the patient to apply it 4
hours before the trip to be effective. Because the question is asking
about a "prescribed" medication, an over-the-counter (OTC) medicine,
such as Dramamine, is an incorrect response. Zofran is indicated for
cancer-related nausea and vomiting (chemotherapy, radiation, surgery).
⩥ The nurse practitioner is completing a health assessment on a 15-year-
old female patient who is in the office for her annual physical. The
patient reports feelings of hopelessness and sadness for several months,
no history of suicidal ideations, and a struggle with anorexia. The patient
scores an 11 on Beck's Depression Inventory. Which antidepressant will
the nurse practitioner prescribe?
a. Sertraline (Zoloft)
b. Lithium carbonate (Eskalith)
c. Bupropion (Wellbutrin)
d. Escitalopram (Lexapro). Answer: d. Escitalopram [Lexapro]
Escitalopram is a safe antidepressant for an adolescent who has severe
depression and no history of suicidal ideations. Sertraline is not a safe
option for patients younger than 24 years of age because of increased
risk of suicidal ideation. Bupropion is an atypical antidepressant and is
not a first-line therapy for depression. It is contraindicated in patients
with anorexia nervosa. Lithium is indicated for patients with bipolar
disorder.
, ⩥ Which initial treatment will the nurse practitioner prescribe to a 23-
year-old female allergic to sulfa drugs who is diagnosed with acute
cystitis?
a. Cephalexin (Keflex) 500 mg BID × 5 days
b. Ciprofloxacin (Cipro) 250 mg BID × 3 days
c. Nitrofurantoin (Macrobid) 100 mg BID × 5 days
d. Amoxicillin 500 mg BID × 5 days. Answer: c. Nitrofurantoin
(Macrobid) 100 mg BID × 5 days
Nitrofurantoin can be safely administered to a patient with a sulfa
allergy to treat acute cystitis and is the first line of treatment. Cephalexin
and amoxicillin are beta-lactam antibiotics that can be prescribed for a
patient who has an allergy to sulfa and nitrofurantoin. A
fluoroquinolone, such as ciprofloxacin, is recommended for a patient
who is allergic to sulfa and beta-lactam drugs or has a sulfa allergy and a
known resistance to beta-lactam antibiotics.
⩥ A 68-year-old patient recently prescribed caridopa-levodopa (Sinemet)
tells the nurse practitioner that he has been bloated and experiencing
difficulty with bowel movements. Which medication will the nurse
practitioner consider incorporating into the treatment plan?
a. Senna
