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Summary USMLE Step 1 Rapid Review – High-Yield Study Guide

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Comprehensive USMLE Step 1 rapid review set covering 200+ high-yield medical conditions, syndromes, and pathologies. Includes concise flashcard-style Q&A pairs for quick recall during Step 1 preparation.

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Uploaded on
October 28, 2025
Number of pages
8
Written in
2023/2024
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Summary

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USMLE Step 1 Rapid Review
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Terms in this set (215)


Abdominal pain, ascites, hepatomegaly, Budd-Chiari syndrome
(also high D dimer, CHF without JVD)

Achilles tendon xanthoma Familial hypercholesterolemia

Adrenal hemorrhage, hypotension, DIC Waterhouse-Friderichsen syndrome (meningococcemia)

Arachnodactyly, lens dislocation, aortic Marfan's (fibrillin defect)
dissection, hyperflexible joints

Athlete with polycythemia Erythropoietin injection

Back pain, fever, night sweats, weight loss Pott's (TB to the vertebrae)

Bilateral hilar adenopathy, uveitis Sarcoid

Blue sclera Osteogenesis imperfecta

Bluish line on gingiva Burton's line - lead poisoning

Bone pain, bone enlargement, arthritis, Paget's
(also increased hat size, fracture,
increased alk phos)

Bounding pulses, diastolic hear murmur, Aortic regurg
head bobbing

Café-au-lait spots, Lisch nodules NF (1 = optic glimoas and pheo, 2 = acoustic Schwannomas)

Café-au-lait spots, polyostotic fibrous McCune-Albright syndome (G protein problem)
dysplasia, precocious puberty

Calf pseudohypertrophy Duchenne's muscular dystrophy

Cherry-red spot on macula Tay-Sachs, Niemann-Pick, central retinal artery occlusion

Chest pain, pericardial effusion/friction Dressler's (autoimmune post-MI)
rub, persistent fever following MI

Child uses arms to stand up from squat Gower's sign (Duchenne's)

Child with fever develops red rash on Slapped cheek - B19
face that spreads to body

, Chorea, dementia, caudate degeneration Huntington's

Chronic exercise intolerance with McArdle's (muscle phosphorylase deficiency)
myalgia, fatigue, painful cramps

Cold intolerance Hypothyroidism

Conjugate lateral gaze palsy, horizontal Internuclear ophthalmoplegia (MS or stroke)
diplopia

Continuous machinery heart murmur PDA

Cutaneous/dermal edema due to CT Myxedema
expansion

Dark purple skin / mouth nodules Kaposi's sarcoma

Deep, labored breathing / Kussmaul breathing, DKA
hyperventilation

Dermatitis, dementia, diarrhea Pellagra (B3 / niacin deficiency)

Dilated cardiomyopathy, edema, Wet beriberi (B1 / thiamine deficiency)
polyneuropathy

Dog or cat bite resulting in infection Pasteurella multocida (local cellulitis)

Dry eyes, dry mouth, arthritis Sjogren's syndrome

Dysphagia (esophageal webs), glossitis Plummer-Vinson syndrome
(smooth tongue), iron deficiency anemia

Elastic skin, hypermobility of joints Ehler-Danlos (type III collagen)

Enlarged. hard left supraclavicular node VIrchow's node (abdominal met)

Erythroderma, lymphadenopathy, Sezary syndrome (cutaneous T cell lymphoma)
hepatosplenomegaly, atypical T cells

Facial muscle spasm upon tapping Chvostek's sign (hypocalcemia)

Fat, female, fertile, forty Gallstones

Fever, chills, headache, myalgia following Jarisch-Herxheimer reaction (lysis of spirochetes results in toxin release)
antibiotic treatment for syphillis

Fever, cough, conjunctivitis, coryza, Measles
diffuse rash, Koplick spots

Fever, night sweats, weight loss B symptoms or TB

Fibrous plaques in soft tissue of penis Peyronie's disease

Gout, MR, self-mutilating behavior in a Lesch-Nyhan syndrome (HGPRT deficiency, X-linked recessive)
boy

Green-yellow rings around peripheral iris Kayser-Fleischer rings (copper accumulation from Wilson's disease)

Hamartomatous GI polyps, Peutz-Jeghers syndrome
hyperpigmentation of mouth, feet and
hands

Hepatosplenomegaly, osteoporosis, Gaucher's disease (glucocerebrosidase deficiency)
neurologic symptoms, crinkled cytoplasm

Hereditary nephritis, sensorineural Alport's syndrome (type IV collagen)
hearing loss, cataracts

Hypercoagulability leading to Trousseau's sign (adenocarcinoma of pancreas or lung)
thrombophlebitis

Hyperphagia, hypersexuality, hyperorality, Kluver-Bucy syndrome (bilateral amygdala)
hyperdocility

HTN, hypoK, metabolic alkalosis Conn's (1* hyperaldosterone)
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