PHM 350 Exam 1 Question and
answers correctly solved 2025/2026
All of the following routes of administration are classified as parenteral except:
A. Sublingual
B. Subcutaneous
C. Transdermal
D. Intramuscular
E. Intravenous - correct answer ✔A. Sublingual
In consideration of production of a particular effect, Drug X, Drug Y, and Drug Z are effective. For this
therapeutic effect, the ED50 of Drug X is 0.01 mg, the ED50 of Drug Y is 1 mg, and the ED50 of Drug Z is
100 mg. Based on this information, you can conclude that:
A. Drug Z should not be used to produce this therapeutic effect
B. BOTH Drug X is the most potent of the three drugs in terms of producing this therapeutic effect AND
Drug X is the safest of the three drugs
C. Drug X is the safest of the three drugs
D. Drug X is an agonist
E. Drug X is the most potent of the three drugs in terms of producing this therapeutic effect - correct
answer ✔E. Drug X is the most potent of the three drugs in terms of producing this therapeutic effect
When two drugs, Drug A and Drug B, which are both substrates for the same drug- metabolizing
enzyme, are present:
A. The change of rate of metabolism of Drug A (compared to the rate of metabolism when only Drug A is
present) depends on the affinity of Drug B and of Drug A for the enzyme
B. There is no effect on the rate of metabolism of these drugs
C. The rate of metabolism of both drugs is increased (compared to the rate of metabolism when only
one drug is present)
, D. The rate of metabolism of the drugs will only change if their metabolism follows zero order kinetics
E. A and C, above - correct answer ✔A. The change of rate of metabolism of Drug A (compared to the
rate of metabolism when only Drug A is present) depends on the affinity of Drug B and of Drug A for the
enzyme
The mean plasma concentration of a drug repeatedly administered at the same dosewith a constant
interval between each consecutive dose:
A. Is the sum of the dose rate (g/min) and the clearance volume rate (ml/min) of the administered drug
B. Is the ratio of the dose rate (g/min) to the clearance volume rate (ml/min) of the administered drug
C. Is the product of the dose rate (g/min) and the clearance volume rate (ml/min) of the administered
drug
D. Will be insufficient to produce a continuous therapeutic effect
E. Is independent of the rate of elimination of the drug (for any given plasma drug concentration) -
correct answer ✔B. Is the ratio of the dose rate (g/min) to the clearance volume rate (ml/min) of the
administered drug
The half-life of drug X, eliminated according to first order kinetics, is 75minutes. Drug X is administered
by intravenous injection. Some time after injection, at a time designated 0minute, the concentration of
drug X was 500mg/ml. After 3hours 45minutes, the concentration of drug X will be:
A. 500mg/ml
B. 250mg/ml
C. 125mg/ml
D. 62.5mg/ml
E. 31.25mg/ml. - correct answer ✔D. 62.5mg/ml
A drug is totally eliminated by metabolism. Which of the following will produce an increase of
concentration of free drug in the plasma?
A. Reabsorption of drug from the renal tubule
B. Displacement of drug from plasma protein (albumin) binding sites
answers correctly solved 2025/2026
All of the following routes of administration are classified as parenteral except:
A. Sublingual
B. Subcutaneous
C. Transdermal
D. Intramuscular
E. Intravenous - correct answer ✔A. Sublingual
In consideration of production of a particular effect, Drug X, Drug Y, and Drug Z are effective. For this
therapeutic effect, the ED50 of Drug X is 0.01 mg, the ED50 of Drug Y is 1 mg, and the ED50 of Drug Z is
100 mg. Based on this information, you can conclude that:
A. Drug Z should not be used to produce this therapeutic effect
B. BOTH Drug X is the most potent of the three drugs in terms of producing this therapeutic effect AND
Drug X is the safest of the three drugs
C. Drug X is the safest of the three drugs
D. Drug X is an agonist
E. Drug X is the most potent of the three drugs in terms of producing this therapeutic effect - correct
answer ✔E. Drug X is the most potent of the three drugs in terms of producing this therapeutic effect
When two drugs, Drug A and Drug B, which are both substrates for the same drug- metabolizing
enzyme, are present:
A. The change of rate of metabolism of Drug A (compared to the rate of metabolism when only Drug A is
present) depends on the affinity of Drug B and of Drug A for the enzyme
B. There is no effect on the rate of metabolism of these drugs
C. The rate of metabolism of both drugs is increased (compared to the rate of metabolism when only
one drug is present)
, D. The rate of metabolism of the drugs will only change if their metabolism follows zero order kinetics
E. A and C, above - correct answer ✔A. The change of rate of metabolism of Drug A (compared to the
rate of metabolism when only Drug A is present) depends on the affinity of Drug B and of Drug A for the
enzyme
The mean plasma concentration of a drug repeatedly administered at the same dosewith a constant
interval between each consecutive dose:
A. Is the sum of the dose rate (g/min) and the clearance volume rate (ml/min) of the administered drug
B. Is the ratio of the dose rate (g/min) to the clearance volume rate (ml/min) of the administered drug
C. Is the product of the dose rate (g/min) and the clearance volume rate (ml/min) of the administered
drug
D. Will be insufficient to produce a continuous therapeutic effect
E. Is independent of the rate of elimination of the drug (for any given plasma drug concentration) -
correct answer ✔B. Is the ratio of the dose rate (g/min) to the clearance volume rate (ml/min) of the
administered drug
The half-life of drug X, eliminated according to first order kinetics, is 75minutes. Drug X is administered
by intravenous injection. Some time after injection, at a time designated 0minute, the concentration of
drug X was 500mg/ml. After 3hours 45minutes, the concentration of drug X will be:
A. 500mg/ml
B. 250mg/ml
C. 125mg/ml
D. 62.5mg/ml
E. 31.25mg/ml. - correct answer ✔D. 62.5mg/ml
A drug is totally eliminated by metabolism. Which of the following will produce an increase of
concentration of free drug in the plasma?
A. Reabsorption of drug from the renal tubule
B. Displacement of drug from plasma protein (albumin) binding sites
