APHON Principles of Chemo and |\ |\ |\ |\ |\
Biotherapy exam with answers |\ |\ |\
Biotherapy - CORRECT ANSWERS ✔✔Targeted anticancer agents
|\ |\ |\ |\ |\ |\ |\
also known as biological response modifiers (BRM)
|\ |\ |\ |\ |\ |\
Tyrosine kinase inhibitors (TKIs) are what class - CORRECT
|\ |\ |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔Biotherapy |\
Monoclonal antibodies (MoAbs) are what class - CORRECT
|\ |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔Biotherapy |\
Define pharmacokinetics - CORRECT ANSWERS ✔✔Study of drug
|\ |\ |\ |\ |\ |\ |\ |\
absorption, metabolism, and excretion |\ |\ |\
Define pharmacodynamics - CORRECT ANSWERS ✔✔The
|\ |\ |\ |\ |\ |\
concentration of the drug in the body and how it produces a
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
response
Define adjuvant chemotherapy - CORRECT ANSWERS ✔✔The use
|\ |\ |\ |\ |\ |\ |\ |\
of chemo after another type of therapy, such as surgery, to treat
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
residual disease or undetectable metastasis.
|\ |\ |\ |\
Define neoadjuvant chemotherapy - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\
✔✔When chemo is used preoperatively to decrease tumor burden
|\ |\ |\ |\ |\ |\ |\ |\
in order to make it easier to remove the tumor surgically.
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
, Define sanctuary sites - CORRECT ANSWERS ✔✔Sites within the
|\ |\ |\ |\ |\ |\ |\ |\ |\
body where tumor cells sequester and are not easily reached by
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
chemo such as the CNS |\ |\ |\ |\
What normal cells are most often effected by chemotherapy -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔Hematopoietic, mucosal (mouth & GI),
|\ |\ |\ |\ |\ |\ |\
hair follicles
|\
Why use chemotherapy - CORRECT ANSWERS ✔✔To prevent
|\ |\ |\ |\ |\ |\ |\ |\
cancer cells from dividing, metastasizing, and ultimately causing
|\ |\ |\ |\ |\ |\ |\ |\
the death of the patient
|\ |\ |\ |\
Cure - CORRECT ANSWERS ✔✔To permanently eradicate the
|\ |\ |\ |\ |\ |\ |\ |\
cancer
Control - CORRECT ANSWERS ✔✔To extend the length & QOL
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
when cure is not feasible or realistic
|\ |\ |\ |\ |\ |\
Palliation - CORRECT ANSWERS ✔✔Minimize pain and suffering
|\ |\ |\ |\ |\ |\ |\ |\
during end of life |\ |\ |\
Resting phase of cell cycle - CORRECT ANSWERS ✔✔Gap 0 - cells
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
not dividing
|\
Postmitotic phase - CORRECT ANSWERS ✔✔Gap 1 - enzymes |\ |\ |\ |\ |\ |\ |\ |\ |\
needed for DNA synthesis are produced, protein and RNA
|\ |\ |\ |\ |\ |\ |\ |\ |\
synthesis takes place (18 Hours) |\ |\ |\ |\
Biotherapy exam with answers |\ |\ |\
Biotherapy - CORRECT ANSWERS ✔✔Targeted anticancer agents
|\ |\ |\ |\ |\ |\ |\
also known as biological response modifiers (BRM)
|\ |\ |\ |\ |\ |\
Tyrosine kinase inhibitors (TKIs) are what class - CORRECT
|\ |\ |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔Biotherapy |\
Monoclonal antibodies (MoAbs) are what class - CORRECT
|\ |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔Biotherapy |\
Define pharmacokinetics - CORRECT ANSWERS ✔✔Study of drug
|\ |\ |\ |\ |\ |\ |\ |\
absorption, metabolism, and excretion |\ |\ |\
Define pharmacodynamics - CORRECT ANSWERS ✔✔The
|\ |\ |\ |\ |\ |\
concentration of the drug in the body and how it produces a
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
response
Define adjuvant chemotherapy - CORRECT ANSWERS ✔✔The use
|\ |\ |\ |\ |\ |\ |\ |\
of chemo after another type of therapy, such as surgery, to treat
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
residual disease or undetectable metastasis.
|\ |\ |\ |\
Define neoadjuvant chemotherapy - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\
✔✔When chemo is used preoperatively to decrease tumor burden
|\ |\ |\ |\ |\ |\ |\ |\
in order to make it easier to remove the tumor surgically.
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
, Define sanctuary sites - CORRECT ANSWERS ✔✔Sites within the
|\ |\ |\ |\ |\ |\ |\ |\ |\
body where tumor cells sequester and are not easily reached by
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
chemo such as the CNS |\ |\ |\ |\
What normal cells are most often effected by chemotherapy -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔Hematopoietic, mucosal (mouth & GI),
|\ |\ |\ |\ |\ |\ |\
hair follicles
|\
Why use chemotherapy - CORRECT ANSWERS ✔✔To prevent
|\ |\ |\ |\ |\ |\ |\ |\
cancer cells from dividing, metastasizing, and ultimately causing
|\ |\ |\ |\ |\ |\ |\ |\
the death of the patient
|\ |\ |\ |\
Cure - CORRECT ANSWERS ✔✔To permanently eradicate the
|\ |\ |\ |\ |\ |\ |\ |\
cancer
Control - CORRECT ANSWERS ✔✔To extend the length & QOL
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
when cure is not feasible or realistic
|\ |\ |\ |\ |\ |\
Palliation - CORRECT ANSWERS ✔✔Minimize pain and suffering
|\ |\ |\ |\ |\ |\ |\ |\
during end of life |\ |\ |\
Resting phase of cell cycle - CORRECT ANSWERS ✔✔Gap 0 - cells
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
not dividing
|\
Postmitotic phase - CORRECT ANSWERS ✔✔Gap 1 - enzymes |\ |\ |\ |\ |\ |\ |\ |\ |\
needed for DNA synthesis are produced, protein and RNA
|\ |\ |\ |\ |\ |\ |\ |\ |\
synthesis takes place (18 Hours) |\ |\ |\ |\
