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ANCC PMHNP Practice Questions with 100%
Correct Answers 2025 | 2026
A 14-year-old patient has nonspecific complaints about pain in
his or her legs. The physical examination is unremarkable.
Laboratory results are within normal limits except for a
markedly elevated alkaline phosphatase level. The psychiatric-
mental health nurse practitioner:
A. interprets the findings as normally occurring during a rapid
adolescent growth spurt.
B. obtains a rheumatoid profile because elevated alkaline
phosphatase is a sign of early rheumatic fever.
C. orders a repeat blood test.
D. suspects that the patient has acute pancreatitis.
interprets the findings as normally occurring during a rapid
adolescent growth spurt.
Laboratory findings for a patient with an alcohol use disorder
indicate increased liver function values and:
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A. a decreased mean corpuscular volume (MCV) and normal
triglyceride levels.
B. elevated potassium and chloride levels
C. increased MCV and elevated triglyceride levels
D. increased urine and serum creatinine levels.
increased MCV and elevated triglyceride levels.
A new patient arrives at the office for treatment for depression.
The patient reports taking simvastatin (Zocor) and lisinopril
(Zestril). When selecting an antidepressant, the psychiatric-
mental health nurse practitioner eliminates fluoxetine (Prozac),
based on the knowledge that the combination can lead to
increased plasma levels of the statin, resulting in an increased
risk of muscle damage and rhabdomyolysis. The nurse
practitioner's reason is that:
A. both medications are CYP450 3A4 inhibitors
B. both medications are CYP450 3A4 substrates
C. one medication is a CYP450 3A4 substrate and one is a
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CYP450 3A4 inducer
D. one medication is a CYP450 3A4 substrate and one is a
CYP450 3A4 inhibitor.
one medication is a CYP450 3A4 substrate and one is a CYP450
3A4 inhibitor.
During a mental status examination, an 18-year-old patient
reports feeling bugs crawling under the skin. The psychiatric-
mental health nurse practitioner documents this statement as:
A. a developmental disorder, and suspects cocaine use
B. a hypnagogic hallucination, and suspects schizophrenia
C. a hypnopompic hallucination, and suspects schizophrenia
D. a perceptual disturbance, and suspects the use of cocaine.
a perceptual disturbance, and suspects the use of cocaine.
The psychiatric-mental health nurse practitioner is responsible
for initiating quality improvement at a community mental
health clinic. The effective strategy for evaluating the clinic's
services is to:
ANCC PMHNP Practice Questions with 100%
Correct Answers 2025 | 2026
A 14-year-old patient has nonspecific complaints about pain in
his or her legs. The physical examination is unremarkable.
Laboratory results are within normal limits except for a
markedly elevated alkaline phosphatase level. The psychiatric-
mental health nurse practitioner:
A. interprets the findings as normally occurring during a rapid
adolescent growth spurt.
B. obtains a rheumatoid profile because elevated alkaline
phosphatase is a sign of early rheumatic fever.
C. orders a repeat blood test.
D. suspects that the patient has acute pancreatitis.
interprets the findings as normally occurring during a rapid
adolescent growth spurt.
Laboratory findings for a patient with an alcohol use disorder
indicate increased liver function values and:
,2|Page
A. a decreased mean corpuscular volume (MCV) and normal
triglyceride levels.
B. elevated potassium and chloride levels
C. increased MCV and elevated triglyceride levels
D. increased urine and serum creatinine levels.
increased MCV and elevated triglyceride levels.
A new patient arrives at the office for treatment for depression.
The patient reports taking simvastatin (Zocor) and lisinopril
(Zestril). When selecting an antidepressant, the psychiatric-
mental health nurse practitioner eliminates fluoxetine (Prozac),
based on the knowledge that the combination can lead to
increased plasma levels of the statin, resulting in an increased
risk of muscle damage and rhabdomyolysis. The nurse
practitioner's reason is that:
A. both medications are CYP450 3A4 inhibitors
B. both medications are CYP450 3A4 substrates
C. one medication is a CYP450 3A4 substrate and one is a
, 3|Page
CYP450 3A4 inducer
D. one medication is a CYP450 3A4 substrate and one is a
CYP450 3A4 inhibitor.
one medication is a CYP450 3A4 substrate and one is a CYP450
3A4 inhibitor.
During a mental status examination, an 18-year-old patient
reports feeling bugs crawling under the skin. The psychiatric-
mental health nurse practitioner documents this statement as:
A. a developmental disorder, and suspects cocaine use
B. a hypnagogic hallucination, and suspects schizophrenia
C. a hypnopompic hallucination, and suspects schizophrenia
D. a perceptual disturbance, and suspects the use of cocaine.
a perceptual disturbance, and suspects the use of cocaine.
The psychiatric-mental health nurse practitioner is responsible
for initiating quality improvement at a community mental
health clinic. The effective strategy for evaluating the clinic's
services is to:
