BOC Hematology Exam Questions with Verified Solutions 100% Verified
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1. 1) The light-colored zone adjacent to the nucleus in a plasmacyte is the:
a. ribosome
b. chromatin
c. mitochondria
d. Golgi area: d (Morphological identifiable perinuclear halo.)
2. 3) The majority of the iron in an adult is found as a constituent of:
a. hemoglobin
b. hemosiderin
c. myoglobin
d. transferrin: a (2/3 iron in body bound to Hgb.)
3. 4) The main function of the hexose monophosphate shunt in the erythrocyte
is to:
a. regulate the level of 2,3-DPG
b. provide reduced glutathione to prevent oxidation of hemoglobin
c. prevent the reduction of heme iron
d. provide energy for membrane maintenance: b (Maintains in Fe++ form by way of reduced
glutathione.)
4. 10) In order for hemoglobin to combine reversibly with oxygen, the iron must
be:
a. complexed with haptoglobin
b. freely circulating in the cytoplasm
c. attached to transferrin
d. in the ferrous state: d (Functional form of Fe [reduced].)
5. 11) In which of the following disease states are teardrop cells and abnormal
platelets most characteristically seen?
a. hemolytic anemia
b. multiple myeloma
c. G-6-PD deficiency
d. myeloid metaplasia: d (RBC morphology; disease state identification.)
6. 13) In the normal adult, the spleen acts as a site for:
a. storage of RBCs
b. production of RBCs
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c. synthesis of erythropoietin
d. removal of imperfect and aging cells: d (Major site of destruction of senescent red blood cells.)
7. 14) After the removal of RBCs from the circulation hemoglobin is broken down
into:
a. iron, prophyrin, amino acids
b. iron, protoporphyrin, globin
c. heme, protoporphyrin, amino acids
d. heme, hemosiderin, globin: b (Normal degradation products of red blood cells.)
8. 15) Heinz bodies are:
a. readily identified with polychrome stains
b. rarely found in glucose-6-phosphate dehydrogenase deficient erythrocytes
c. closely associated with spherocytes
d. denatured hemoglobin inclusion that are readily removed by the spleen: d
(Formed with oxidization of Fe and formation of methemoglobin.)
9. 17) Cells for the transport of O2 and CO2 are:
a. erythrocytes
b. granulocytes
c. lymphocytes
d. thrombocytes: a (Primary functions of red blood cells.)
10. 18) Erythropoietin acts as:
a. shorten the replication time of the granulocytes
b. stimulate RNA synthesis of erythroid cells
c. increase colony-stimulating factors produced by the B-lymphs
d. decrease the release of marrow reticulocytes: b (Erythropoietin action.)
11. 19) What cell shape is most commonly associated with an increased MCHC?
a. teardrop cells
b. target cells
c. spherocytes
d. sickle cells: c (May be referred to as hyperchromic because of decreased MCHC.)
12. 27) Which of the following characteristics are common to hereditary sphe-
rocytosis, hereditary elliptocytosis, hereditary stomatocytosis, and paroxysmal
nocturnal hemoglobinuria?
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a. autosomal dominant inheritance
b. red cell membrane defect
c. positive DAT
d. measured platelet count: b (RBC membrane defects are common to PNH, HS, and HE.)
13. 30) Which of the following is most closely associated with iron deficiency
anemia?
a. iron overload in tissue
b. target cells
c. basophilic stippling
d. chronic blood loss: d (Chronic blood loss frequently results in iron deficiency anemia.)
14. 32) Evidence indicates that the genetic defect in thalassemia usually results
in:
a. the production of abnormal globin chains
b. a quantitative deficiency in RNA resulting in decreased globin chain produc-
tion
c. a structural change in the heme portion of the hemoglobin
d. an abnormality in the alpha- or beta- chain binding or affinity: b (Mechanism of
genetic abnormality in thalassemia reduces globin chain production.)
15. 36) An enzyme deficiency associated with a moderate to severe hemolytic
anemia after the patient is exposed to certain drugs and characterized by red
cell inclusions formed by denatured hemoglobin is:
a. LD deficiency
b. G-6-PD deficiency
c. pyruvate kinase deficiency
d. hexokinase deficiency: b (G-6-PD deficiency.)
16. 37) Patients with A(-) type G-6-PD deficiency are least likely to have hemolytic
episodes in which of the following situations?
a. following the administration of oxidizing drugs
b. following the ingestion of fava beans
c. during infections
d. spontaneously: d (G-6-PD deficiency-hemolytic stimulus.)
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17. 38) A patient has a congenital nonspherocytic hemolytic anemia. After expo-
sure to anti-malarial drugs the patient experiences a severe hemolytic episode.
This episode is characterized by red cell inclusions caused by hemoglobin
denaturation. Which of the following conditions is consistent with these find-
ings?
a. G-6-PD deficiency
b. thalassemia major
c. pyruvate kinase deficiency
d. paroxysmal nocturnal hemoglobinuria: a (G-6-PD deficiency-anti-malarial drugs.)
18. 40) Peripheral blood smears from patients with untreated anemia are char-
acterized by:
a. pancytopenia and macrocytosis
b. leukocytosis and elliptocytosis
c. leukocytosis and ovalocytes
d. pancytopenia and microcytosis: a (Patients with pernicious anemia have fewer of all types of blood
cells, but they are abnormally large.)
19. 41) Lab tests performed on a patient indicate macrocytosis, anemia, leukope-
nia and thrombocytopenia. Which of the following disorders is the patient most
likely to have?
a. anemia of chronic disorder
b. vitamin B12 deficiency
c. iron deficiency
d. acute hemorrhage: b (Anemia differentiation-vitamin B12 deficiency results in pernicious anemia [pan-
cytopenia, macrocytosis].)
20. 43) The characteristic morphologic feature in folic acid deficiency is:
a. macrocytosis
b. target cells
c. basophilic stippling
d. rouleaux formation: a (Folate deficiency-peripheral smear will show abnormally large RBCs.)
21. 45) The most likely cause of the macrocytosis that often accompanies anemia
of myelofibrosis is:
a. folic acid deficiency
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1. 1) The light-colored zone adjacent to the nucleus in a plasmacyte is the:
a. ribosome
b. chromatin
c. mitochondria
d. Golgi area: d (Morphological identifiable perinuclear halo.)
2. 3) The majority of the iron in an adult is found as a constituent of:
a. hemoglobin
b. hemosiderin
c. myoglobin
d. transferrin: a (2/3 iron in body bound to Hgb.)
3. 4) The main function of the hexose monophosphate shunt in the erythrocyte
is to:
a. regulate the level of 2,3-DPG
b. provide reduced glutathione to prevent oxidation of hemoglobin
c. prevent the reduction of heme iron
d. provide energy for membrane maintenance: b (Maintains in Fe++ form by way of reduced
glutathione.)
4. 10) In order for hemoglobin to combine reversibly with oxygen, the iron must
be:
a. complexed with haptoglobin
b. freely circulating in the cytoplasm
c. attached to transferrin
d. in the ferrous state: d (Functional form of Fe [reduced].)
5. 11) In which of the following disease states are teardrop cells and abnormal
platelets most characteristically seen?
a. hemolytic anemia
b. multiple myeloma
c. G-6-PD deficiency
d. myeloid metaplasia: d (RBC morphology; disease state identification.)
6. 13) In the normal adult, the spleen acts as a site for:
a. storage of RBCs
b. production of RBCs
, BOC Hematology Exam Questions with Verified Solutions 100% Verified
Study online at https://quizlet.com/_i2u0r7
c. synthesis of erythropoietin
d. removal of imperfect and aging cells: d (Major site of destruction of senescent red blood cells.)
7. 14) After the removal of RBCs from the circulation hemoglobin is broken down
into:
a. iron, prophyrin, amino acids
b. iron, protoporphyrin, globin
c. heme, protoporphyrin, amino acids
d. heme, hemosiderin, globin: b (Normal degradation products of red blood cells.)
8. 15) Heinz bodies are:
a. readily identified with polychrome stains
b. rarely found in glucose-6-phosphate dehydrogenase deficient erythrocytes
c. closely associated with spherocytes
d. denatured hemoglobin inclusion that are readily removed by the spleen: d
(Formed with oxidization of Fe and formation of methemoglobin.)
9. 17) Cells for the transport of O2 and CO2 are:
a. erythrocytes
b. granulocytes
c. lymphocytes
d. thrombocytes: a (Primary functions of red blood cells.)
10. 18) Erythropoietin acts as:
a. shorten the replication time of the granulocytes
b. stimulate RNA synthesis of erythroid cells
c. increase colony-stimulating factors produced by the B-lymphs
d. decrease the release of marrow reticulocytes: b (Erythropoietin action.)
11. 19) What cell shape is most commonly associated with an increased MCHC?
a. teardrop cells
b. target cells
c. spherocytes
d. sickle cells: c (May be referred to as hyperchromic because of decreased MCHC.)
12. 27) Which of the following characteristics are common to hereditary sphe-
rocytosis, hereditary elliptocytosis, hereditary stomatocytosis, and paroxysmal
nocturnal hemoglobinuria?
, BOC Hematology Exam Questions with Verified Solutions 100% Verified
Study online at https://quizlet.com/_i2u0r7
a. autosomal dominant inheritance
b. red cell membrane defect
c. positive DAT
d. measured platelet count: b (RBC membrane defects are common to PNH, HS, and HE.)
13. 30) Which of the following is most closely associated with iron deficiency
anemia?
a. iron overload in tissue
b. target cells
c. basophilic stippling
d. chronic blood loss: d (Chronic blood loss frequently results in iron deficiency anemia.)
14. 32) Evidence indicates that the genetic defect in thalassemia usually results
in:
a. the production of abnormal globin chains
b. a quantitative deficiency in RNA resulting in decreased globin chain produc-
tion
c. a structural change in the heme portion of the hemoglobin
d. an abnormality in the alpha- or beta- chain binding or affinity: b (Mechanism of
genetic abnormality in thalassemia reduces globin chain production.)
15. 36) An enzyme deficiency associated with a moderate to severe hemolytic
anemia after the patient is exposed to certain drugs and characterized by red
cell inclusions formed by denatured hemoglobin is:
a. LD deficiency
b. G-6-PD deficiency
c. pyruvate kinase deficiency
d. hexokinase deficiency: b (G-6-PD deficiency.)
16. 37) Patients with A(-) type G-6-PD deficiency are least likely to have hemolytic
episodes in which of the following situations?
a. following the administration of oxidizing drugs
b. following the ingestion of fava beans
c. during infections
d. spontaneously: d (G-6-PD deficiency-hemolytic stimulus.)
, BOC Hematology Exam Questions with Verified Solutions 100% Verified
Study online at https://quizlet.com/_i2u0r7
17. 38) A patient has a congenital nonspherocytic hemolytic anemia. After expo-
sure to anti-malarial drugs the patient experiences a severe hemolytic episode.
This episode is characterized by red cell inclusions caused by hemoglobin
denaturation. Which of the following conditions is consistent with these find-
ings?
a. G-6-PD deficiency
b. thalassemia major
c. pyruvate kinase deficiency
d. paroxysmal nocturnal hemoglobinuria: a (G-6-PD deficiency-anti-malarial drugs.)
18. 40) Peripheral blood smears from patients with untreated anemia are char-
acterized by:
a. pancytopenia and macrocytosis
b. leukocytosis and elliptocytosis
c. leukocytosis and ovalocytes
d. pancytopenia and microcytosis: a (Patients with pernicious anemia have fewer of all types of blood
cells, but they are abnormally large.)
19. 41) Lab tests performed on a patient indicate macrocytosis, anemia, leukope-
nia and thrombocytopenia. Which of the following disorders is the patient most
likely to have?
a. anemia of chronic disorder
b. vitamin B12 deficiency
c. iron deficiency
d. acute hemorrhage: b (Anemia differentiation-vitamin B12 deficiency results in pernicious anemia [pan-
cytopenia, macrocytosis].)
20. 43) The characteristic morphologic feature in folic acid deficiency is:
a. macrocytosis
b. target cells
c. basophilic stippling
d. rouleaux formation: a (Folate deficiency-peripheral smear will show abnormally large RBCs.)
21. 45) The most likely cause of the macrocytosis that often accompanies anemia
of myelofibrosis is:
a. folic acid deficiency
