Pharm II Liver Disease, NASH and hepatic encephalopathy Exam
1. what helps quantify effects of cirrhosis: child Pugh score
2. child pugh score measures: total bilirubin
albumin
ascites
encephalopathy
prothrombin time (seconds)
3. lifestyle changes for cirrhosis: alcohol cessation
sodium restriction
adjust medications to avoid toxicity
hep A and B vaccine
hep c antiviral
4. nonalcoholic fatty liver disease or nonalcoholic steatohepatitis treatment if
BMI >27: first line: semaglutide
alternative: liraglutide
5. NAFLD or NASH treatment if BMI > 30: bariatric surgery
1/5
, 6. preferred treatment for type 2 DM with NASH or NAFLD: GLP-1
GLP-1/GIP
pioglitazone
or combo GLP-1 w pioglitazone
7. treatment of portal hypertension: nonselective beta blockers:
propranolol
nadolol
carvedilol
8. varices: weak superficial vessels
9. primary prophylaxis for varices (before they bleed): nonselective beta blocker indefinitely
propranolol
nadolol
carvedilol
endoscopic variceal ligation
endoscopic band ligation
10. treatment of bleeding from varices: transfusion if Hb<7 g/dL
endoscopy, EVL within 12 hours admission
2/5
1. what helps quantify effects of cirrhosis: child Pugh score
2. child pugh score measures: total bilirubin
albumin
ascites
encephalopathy
prothrombin time (seconds)
3. lifestyle changes for cirrhosis: alcohol cessation
sodium restriction
adjust medications to avoid toxicity
hep A and B vaccine
hep c antiviral
4. nonalcoholic fatty liver disease or nonalcoholic steatohepatitis treatment if
BMI >27: first line: semaglutide
alternative: liraglutide
5. NAFLD or NASH treatment if BMI > 30: bariatric surgery
1/5
, 6. preferred treatment for type 2 DM with NASH or NAFLD: GLP-1
GLP-1/GIP
pioglitazone
or combo GLP-1 w pioglitazone
7. treatment of portal hypertension: nonselective beta blockers:
propranolol
nadolol
carvedilol
8. varices: weak superficial vessels
9. primary prophylaxis for varices (before they bleed): nonselective beta blocker indefinitely
propranolol
nadolol
carvedilol
endoscopic variceal ligation
endoscopic band ligation
10. treatment of bleeding from varices: transfusion if Hb<7 g/dL
endoscopy, EVL within 12 hours admission
2/5
