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Test 4 Questions With Correct Answers
/ // // // // //
A //fibrin //network //that //contains //trapped //blood //cells //and //platelets //is //called //a(n)
clot
platelets //have //this //cell //in //it's //lineage //in //common //with //all //other //blood //cells
pleura //potential //hematopoietic //cell //(stem //cell)
1st //cell //that //is //identified //as //distinctly //a //part //of //the //platelet //lineage
megakaryoblast
differentiation //progression //for //platelets
stem //cell //=> //megakaryoblast //=> //megakaryocyte //=fragments //into=> //platelets
platelets //don't //have //a...
nucleus
normal //range //for //platelets
150,000 //- //450,000/mL
platelet //half //life
8-12 //days
Cytoplasm //of //platelets //contain
-contractile //proteins
-ER //and //golgi
-mitochondria
-prostaglandins //and //thromboxin
-fibrin //stabilizing //factor //synthesis
-growth //factors
,purpose //of //the //ER //and //golgi //apparatus //in //platelets
-Ca++ //storage
-enzyme //synthesis //for //platelet //function //and //coagulation //factors
types //of //contractile //proteins //found //in //platelets
actin, //myosin, //thrombosthenin
function //of //PG //and //TxA2
platelet //aggregation //, //platelet //anti-aggregation //and //vasoconstriction
function //of //fibrin //stabilizing //factor
stablizes //fibrin //threads //and //clot
Platelet //Cell //Membrane //contains:
-
glycoprotein //coating //( //prevents //platelets //from //adhering //to //normal //vascular //endothelium)
-phospholipids
-receptors //(allow //for //activation)
Definition //of //hemostasis
prevention //of //blood //loss
hemostasis //is //achieved //by //these //mechanisms //in //this //order
- //vascular //constriction
- //platelet //plug //formation
- //blood //coagulation/clot
- //fibrin //formation //& //repair //of //injured //vessel
- //clot //lysis
mechanisms //for //vascular //constriction //for //hemostasis
reflex //vascular //smooth //muscle //spasm, //pain //-> //SNS //reflex //-
> //(norepinephrine, //epi)vaso //constriction
platelet //release //of //TxA2
the //greater //the //trauma //the //greater //the....
,vasoconstriction. /
/thus....a //cut //shaving //bleeds //a //lot //but //a //severed //limb....not //as //much //as //you //might //think
platelet /
/activation //is //caused //by //contact //with //this //substance //in //damaged //vascular //endothelium
collegen
First //step //of //platelet //plug //formation
platelets //swell //and //exude //pseudopods
second //step //in //platelet //plug //formation
actin, //myosin, //and //thrombosthenin //contract //= //release //of //clotting //factors.
third //step //in //platelet //plug //formation
platelets //become //sticky, //aggregate, //and //adhere //to //collagen //and //von //Willebrand //factor //in
//blood //vessel //wall
fourth //step //in //platelet //plug //formation
ADP //and //TxA2 //secretion //activates //other //platelets
fifth //step //in //platelet //plug //formation
expression //of //fibrinogen //receptors
sixth //step //in //platelet //plug //formation
fibrin //threads //form //in //plug //(mesh //like)
is //a //platelet //plug //the //same //as //a //clot?
no. /
/platelet /
/plugs /
/are /
/good /
/for //small //damage //but //blood //coagulation //and //clot //formation //are //for //bigger //damage.
von //Willebrand //factor
-produced //in //the //vascular //endothelial //cells
-very //important //for //clot //and //platelet //plug //formation
-people //can //be //born //without //it.
, Tx //for //von //Willebrand //deficiency
-give //von //WIllebrand //factor
-give //cryoprecipitate
-give //DDADP //(desmopressin)
how //fast //does //clot //formation //start //in //a //small //wound?
1-2min
amount //of //time //for //clot //formation //in //a //large/serious //wound
15-20 //sec
amount //of //time //required //for //a //tear //in //a //blood //vessel //to //be //filled //with //a //clot
3-6min
amount //of //time //before //the //clot //retracts //and //further //closes //the //wound //in //the //vessel
20-60min
during //normal //conditions, //does //anticoagulant //or //procoagulant //factors //predominate?
anticoagulant
this //is //essential //for //pro-coagulant //factors
it //must //stay //local //at //the //site //of //injury!
2 //types //of //coagulation //pathways
extrinsic //and //intrinsic
initiating //stimuli //in //the //extrinsic //coagulation //pathway
tissue //damage //extrinsic //to //the //blood //vessel
initiating //stimuli //in //the //intrinsic //coagulation //pathway
contact //with //collagen //of //damaged //vessel
at //what //point //do //the //coagulation //pathways //become //a //common //pathway
factor //X
tissue //damage //causes //the //release //of
thromboplastin
in //the //extrinsic //coagulation //pathway, //thromboplastin
Advanced
/ /
Physiology
/ /
Test 4 Questions With Correct Answers
/ // // // // //
A //fibrin //network //that //contains //trapped //blood //cells //and //platelets //is //called //a(n)
clot
platelets //have //this //cell //in //it's //lineage //in //common //with //all //other //blood //cells
pleura //potential //hematopoietic //cell //(stem //cell)
1st //cell //that //is //identified //as //distinctly //a //part //of //the //platelet //lineage
megakaryoblast
differentiation //progression //for //platelets
stem //cell //=> //megakaryoblast //=> //megakaryocyte //=fragments //into=> //platelets
platelets //don't //have //a...
nucleus
normal //range //for //platelets
150,000 //- //450,000/mL
platelet //half //life
8-12 //days
Cytoplasm //of //platelets //contain
-contractile //proteins
-ER //and //golgi
-mitochondria
-prostaglandins //and //thromboxin
-fibrin //stabilizing //factor //synthesis
-growth //factors
,purpose //of //the //ER //and //golgi //apparatus //in //platelets
-Ca++ //storage
-enzyme //synthesis //for //platelet //function //and //coagulation //factors
types //of //contractile //proteins //found //in //platelets
actin, //myosin, //thrombosthenin
function //of //PG //and //TxA2
platelet //aggregation //, //platelet //anti-aggregation //and //vasoconstriction
function //of //fibrin //stabilizing //factor
stablizes //fibrin //threads //and //clot
Platelet //Cell //Membrane //contains:
-
glycoprotein //coating //( //prevents //platelets //from //adhering //to //normal //vascular //endothelium)
-phospholipids
-receptors //(allow //for //activation)
Definition //of //hemostasis
prevention //of //blood //loss
hemostasis //is //achieved //by //these //mechanisms //in //this //order
- //vascular //constriction
- //platelet //plug //formation
- //blood //coagulation/clot
- //fibrin //formation //& //repair //of //injured //vessel
- //clot //lysis
mechanisms //for //vascular //constriction //for //hemostasis
reflex //vascular //smooth //muscle //spasm, //pain //-> //SNS //reflex //-
> //(norepinephrine, //epi)vaso //constriction
platelet //release //of //TxA2
the //greater //the //trauma //the //greater //the....
,vasoconstriction. /
/thus....a //cut //shaving //bleeds //a //lot //but //a //severed //limb....not //as //much //as //you //might //think
platelet /
/activation //is //caused //by //contact //with //this //substance //in //damaged //vascular //endothelium
collegen
First //step //of //platelet //plug //formation
platelets //swell //and //exude //pseudopods
second //step //in //platelet //plug //formation
actin, //myosin, //and //thrombosthenin //contract //= //release //of //clotting //factors.
third //step //in //platelet //plug //formation
platelets //become //sticky, //aggregate, //and //adhere //to //collagen //and //von //Willebrand //factor //in
//blood //vessel //wall
fourth //step //in //platelet //plug //formation
ADP //and //TxA2 //secretion //activates //other //platelets
fifth //step //in //platelet //plug //formation
expression //of //fibrinogen //receptors
sixth //step //in //platelet //plug //formation
fibrin //threads //form //in //plug //(mesh //like)
is //a //platelet //plug //the //same //as //a //clot?
no. /
/platelet /
/plugs /
/are /
/good /
/for //small //damage //but //blood //coagulation //and //clot //formation //are //for //bigger //damage.
von //Willebrand //factor
-produced //in //the //vascular //endothelial //cells
-very //important //for //clot //and //platelet //plug //formation
-people //can //be //born //without //it.
, Tx //for //von //Willebrand //deficiency
-give //von //WIllebrand //factor
-give //cryoprecipitate
-give //DDADP //(desmopressin)
how //fast //does //clot //formation //start //in //a //small //wound?
1-2min
amount //of //time //for //clot //formation //in //a //large/serious //wound
15-20 //sec
amount //of //time //required //for //a //tear //in //a //blood //vessel //to //be //filled //with //a //clot
3-6min
amount //of //time //before //the //clot //retracts //and //further //closes //the //wound //in //the //vessel
20-60min
during //normal //conditions, //does //anticoagulant //or //procoagulant //factors //predominate?
anticoagulant
this //is //essential //for //pro-coagulant //factors
it //must //stay //local //at //the //site //of //injury!
2 //types //of //coagulation //pathways
extrinsic //and //intrinsic
initiating //stimuli //in //the //extrinsic //coagulation //pathway
tissue //damage //extrinsic //to //the //blood //vessel
initiating //stimuli //in //the //intrinsic //coagulation //pathway
contact //with //collagen //of //damaged //vessel
at //what //point //do //the //coagulation //pathways //become //a //common //pathway
factor //X
tissue //damage //causes //the //release //of
thromboplastin
in //the //extrinsic //coagulation //pathway, //thromboplastin
