Toxicology Exam questions and
answers graded A+
Potency of a drug is reflected by - ANS✅✅the position of the dose response curve along the x-axis
A plot frequency of response vs log dose for a typical drug looks like - ANS✅✅a normal
distribution/ gaussian curve
LD50 is associated with - ANS✅✅NED value of 0
a frequency distribution skewed to the left - ANS✅✅a higher proportion of sensitive subjects
a dose that is estimated to be fatal to 50% of the organisms in a population is referred to as -
ANS✅✅LD50
which unit is most relevant to long-term oral exposure - ANS✅✅mg/kg-day
a term that describes an effect reported by a patient to his or her physician would be: -
ANS✅✅symptom
which of the following would be an example of the term safety - ANS✅✅a 999,999 out of
1,000,000 chance of not getting cancer
a clinical trial in which neither participant nor physician know if the participant is getting drug or
placebo is called - ANS✅✅double blind
an example of a continuous endpoint in toxicology that could be converted to a quantal endpoint is -
ANS✅✅blood pressure elevation
route of exposure presents the least barrier to uptake of a drug into blood - ANS✅✅intravenous
an example of drug tolerance - ANS✅✅The need for larger and larger amounts of drug to get the
same effect in a chronic heroin user
answers graded A+
Potency of a drug is reflected by - ANS✅✅the position of the dose response curve along the x-axis
A plot frequency of response vs log dose for a typical drug looks like - ANS✅✅a normal
distribution/ gaussian curve
LD50 is associated with - ANS✅✅NED value of 0
a frequency distribution skewed to the left - ANS✅✅a higher proportion of sensitive subjects
a dose that is estimated to be fatal to 50% of the organisms in a population is referred to as -
ANS✅✅LD50
which unit is most relevant to long-term oral exposure - ANS✅✅mg/kg-day
a term that describes an effect reported by a patient to his or her physician would be: -
ANS✅✅symptom
which of the following would be an example of the term safety - ANS✅✅a 999,999 out of
1,000,000 chance of not getting cancer
a clinical trial in which neither participant nor physician know if the participant is getting drug or
placebo is called - ANS✅✅double blind
an example of a continuous endpoint in toxicology that could be converted to a quantal endpoint is -
ANS✅✅blood pressure elevation
route of exposure presents the least barrier to uptake of a drug into blood - ANS✅✅intravenous
an example of drug tolerance - ANS✅✅The need for larger and larger amounts of drug to get the
same effect in a chronic heroin user
