APHON Principles of Chemo and
Biotherapy Questions with Verified
Answers
Biotherapy - ANSWERSTargeted anticancer agents also known as biological response
modifiers (BRM)
Tyrosine kinase inhibitors (TKIs) are what class - ANSWERSBiotherapy
Monoclonal antibodies (MoAbs) are what class - ANSWERSBiotherapy
Define pharmacokinetics - ANSWERSStudy of drug absorption, metabolism, and
excretion
Define pharmacodynamics - ANSWERSThe concentration of the drug in the body and
how it produces a response
Define adjuvant chemotherapy - ANSWERSThe use of chemo after another type of
therapy, such as surgery, to treat residual disease or undetectable metastasis.
Define neoadjuvant chemotherapy - ANSWERSWhen chemo is used preoperatively to
decrease tumor burden in order to make it easier to remove the tumor surgically.
Define sanctuary sites - ANSWERSSites within the body where tumor cells sequester
and are not easily reached by chemo such as the CNS
What normal cells are most often effected by chemotherapy -
ANSWERSHematopoietic, mucosal (mouth & GI), hair follicles
Why use chemotherapy - ANSWERSTo prevent cancer cells from dividing,
metastasizing, and ultimately causing the death of the patient
Cure - ANSWERSTo permanently eradicate the cancer
Control - ANSWERSTo extend the length & QOL when cure is not feasible or realistic
Palliation - ANSWERSMinimize pain and suffering during end of life
Resting phase of cell cycle - ANSWERSGap 0 - cells not dividing
Postmitotic phase - ANSWERSGap 1 - enzymes needed for DNA synthesis are
produced, protein and RNA synthesis takes place (18 Hours)
Biotherapy Questions with Verified
Answers
Biotherapy - ANSWERSTargeted anticancer agents also known as biological response
modifiers (BRM)
Tyrosine kinase inhibitors (TKIs) are what class - ANSWERSBiotherapy
Monoclonal antibodies (MoAbs) are what class - ANSWERSBiotherapy
Define pharmacokinetics - ANSWERSStudy of drug absorption, metabolism, and
excretion
Define pharmacodynamics - ANSWERSThe concentration of the drug in the body and
how it produces a response
Define adjuvant chemotherapy - ANSWERSThe use of chemo after another type of
therapy, such as surgery, to treat residual disease or undetectable metastasis.
Define neoadjuvant chemotherapy - ANSWERSWhen chemo is used preoperatively to
decrease tumor burden in order to make it easier to remove the tumor surgically.
Define sanctuary sites - ANSWERSSites within the body where tumor cells sequester
and are not easily reached by chemo such as the CNS
What normal cells are most often effected by chemotherapy -
ANSWERSHematopoietic, mucosal (mouth & GI), hair follicles
Why use chemotherapy - ANSWERSTo prevent cancer cells from dividing,
metastasizing, and ultimately causing the death of the patient
Cure - ANSWERSTo permanently eradicate the cancer
Control - ANSWERSTo extend the length & QOL when cure is not feasible or realistic
Palliation - ANSWERSMinimize pain and suffering during end of life
Resting phase of cell cycle - ANSWERSGap 0 - cells not dividing
Postmitotic phase - ANSWERSGap 1 - enzymes needed for DNA synthesis are
produced, protein and RNA synthesis takes place (18 Hours)
