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APHON Chemo Agents & Classifications Questions with
Detailed Verified Answers
cell cycle specific Ans: ✓ ✓ ✓ affective during specific phase, w/ maximal effect on rapidly dividing
cells
cell cycle non-specific Ans: ✓ ✓ ✓ disregard phase. dose dependent. effective on slow growing
cancer cells b/c cytotoxic in resting phase as well. degree of cell kill directly correlates to dose
administered
alkylating agents Ans: ✓ ✓ ✓ non-specific. although most active in resting phase. cause dna strand
breaks
antimetabolites Ans: ✓ ✓ ✓ interfere w/ cell metabolism by inhibiting enzyme production or
producing nonfunctional end product. interrupts protein synthesis, rna, or dna
anthracyclines Ans: ✓ ✓ ✓ prevent rejoining of cleaved dna strands by inhibiting topoisomerase ii
(dna untangling enzyme). also forms hydroxyl radicals which attack dna/cell membrane lipids
(cardiotoxic)
give cardioprotective agents alongside
abx are subset but breakdown is usually stable
plant derivatives Ans: ✓ ✓ ✓ vinca alkaloids - vcr, vinblastine, vinorelbine, vindesine
tubulin interactive agets: interfere w/ microtubule formation/function leading to arrest in mitosis.
cell cycle specific
taxanes Ans: ✓ ✓ ✓ plant derivitive that inhibits microtubular disassembly necessary to finish
mitosis
epipodophyllotoxins Ans: ✓ ✓ ✓ etoposide, teniposide
inhibit topoisomerase ii and produce dna-strand breaks
© Get it right 2025 Getaway - Stuvia US All rights reserved
APHON Chemo Agents & Classifications Questions with
Detailed Verified Answers
cell cycle specific Ans: ✓ ✓ ✓ affective during specific phase, w/ maximal effect on rapidly dividing
cells
cell cycle non-specific Ans: ✓ ✓ ✓ disregard phase. dose dependent. effective on slow growing
cancer cells b/c cytotoxic in resting phase as well. degree of cell kill directly correlates to dose
administered
alkylating agents Ans: ✓ ✓ ✓ non-specific. although most active in resting phase. cause dna strand
breaks
antimetabolites Ans: ✓ ✓ ✓ interfere w/ cell metabolism by inhibiting enzyme production or
producing nonfunctional end product. interrupts protein synthesis, rna, or dna
anthracyclines Ans: ✓ ✓ ✓ prevent rejoining of cleaved dna strands by inhibiting topoisomerase ii
(dna untangling enzyme). also forms hydroxyl radicals which attack dna/cell membrane lipids
(cardiotoxic)
give cardioprotective agents alongside
abx are subset but breakdown is usually stable
plant derivatives Ans: ✓ ✓ ✓ vinca alkaloids - vcr, vinblastine, vinorelbine, vindesine
tubulin interactive agets: interfere w/ microtubule formation/function leading to arrest in mitosis.
cell cycle specific
taxanes Ans: ✓ ✓ ✓ plant derivitive that inhibits microtubular disassembly necessary to finish
mitosis
epipodophyllotoxins Ans: ✓ ✓ ✓ etoposide, teniposide
inhibit topoisomerase ii and produce dna-strand breaks
© Get it right 2025 Getaway - Stuvia US All rights reserved
