Test Bank For Goodman's Medical Cell Biology
4th Edition Latest edition
Editor: Steven R. Goodman
,Table of contents
1. Tools of the Cell Biologist
John Burr
2. Cell Membranes
Frans Kuypers
3. Cytoskeleton
Warren Zimmer
4. Organelle Structure and Function
Michael Whitt and John Cox
5. Mitochondria and Disease
Taosheng Huang
6. Regulation of Gene Expression
Warren Zimmer
7. Cell Adhesion and ECM
R.K. Rao and Zhaohui Wu
8. Intercellular Signaling
Danna Zimmer
9. Cell Signaling Events
Leszek Kotula and Angelina Regua
10. Cell Cycle and Cancer
Peter Stambrook
11. Programmed Cell Death
Santosh D’Mello
12. The Cell Biology of the Immune System
Mohammad Ibrahim
13. Stem Cells and Regenerative Medicine
James Kang
14. Omics, Informatics, and Precision Medicine
Robert Williams and Valeria Mas
15. The Microbiome and Human Disease
John Cryan
,Clinical Cases for Chapters 2-14
Karen Johnson and Ari Vanderwalde
, Chapter 1: Tools of the Cell Biologist from Goodman’s Medical Cell Biology, 4th Edition by
John Burr.
1. Which type of microscopy provides the highest resolution for studying the internal structure of
cellular organelles?
A. Bright-field microscopy
B. Transmission electron microscopy (TEM)
C. Scanning electron microscopy (SEM)
D. Phase-contrast microscopy
Answer: B
Rationale: TEM allows visualization of internal ultrastructures of the cell at nanometer
resolution by passing electrons through thin sections, whereas SEM focuses on surface topology.
2. The function of fluorescence microscopy in cell biology is primarily to:
A. Visualize unstained living cells
B. Detect specific proteins using fluorescently labeled molecules
C. Enhance contrast through phase differences
D. Study atomic-level surface detail
Answer: B
Rationale: Fluorescence microscopy uses fluorescent dyes or proteins that bind to specific
targets, allowing localization and study of specific biomolecules within cells.
3. In confocal microscopy, the pinhole aperture serves to:
A. Reduce background light and improve image clarity
B. Increase overall light intensity
C. Enable transmission of all emitted light
D. Increase field of view
Answer: A
Rationale: The pinhole filters out out-of-focus light, resulting in sharp optical sections and 3D
reconstruction capability.
4. Which of the following is a key advantage of phase-contrast microscopy?
A. Visualization of fluorescent markers
B. High-resolution surface imaging
C. Observation of living, unstained cells
D. Requires thin tissue sections
Answer: C
Rationale: Phase-contrast microscopy converts phase shifts in light passing through transparent
specimens into contrast, making live cells visible without staining.
5. The main limitation of light microscopy is:
A. Inability to image color
B. Poor depth perception
C. Resolution limited by the wavelength of light
4th Edition Latest edition
Editor: Steven R. Goodman
,Table of contents
1. Tools of the Cell Biologist
John Burr
2. Cell Membranes
Frans Kuypers
3. Cytoskeleton
Warren Zimmer
4. Organelle Structure and Function
Michael Whitt and John Cox
5. Mitochondria and Disease
Taosheng Huang
6. Regulation of Gene Expression
Warren Zimmer
7. Cell Adhesion and ECM
R.K. Rao and Zhaohui Wu
8. Intercellular Signaling
Danna Zimmer
9. Cell Signaling Events
Leszek Kotula and Angelina Regua
10. Cell Cycle and Cancer
Peter Stambrook
11. Programmed Cell Death
Santosh D’Mello
12. The Cell Biology of the Immune System
Mohammad Ibrahim
13. Stem Cells and Regenerative Medicine
James Kang
14. Omics, Informatics, and Precision Medicine
Robert Williams and Valeria Mas
15. The Microbiome and Human Disease
John Cryan
,Clinical Cases for Chapters 2-14
Karen Johnson and Ari Vanderwalde
, Chapter 1: Tools of the Cell Biologist from Goodman’s Medical Cell Biology, 4th Edition by
John Burr.
1. Which type of microscopy provides the highest resolution for studying the internal structure of
cellular organelles?
A. Bright-field microscopy
B. Transmission electron microscopy (TEM)
C. Scanning electron microscopy (SEM)
D. Phase-contrast microscopy
Answer: B
Rationale: TEM allows visualization of internal ultrastructures of the cell at nanometer
resolution by passing electrons through thin sections, whereas SEM focuses on surface topology.
2. The function of fluorescence microscopy in cell biology is primarily to:
A. Visualize unstained living cells
B. Detect specific proteins using fluorescently labeled molecules
C. Enhance contrast through phase differences
D. Study atomic-level surface detail
Answer: B
Rationale: Fluorescence microscopy uses fluorescent dyes or proteins that bind to specific
targets, allowing localization and study of specific biomolecules within cells.
3. In confocal microscopy, the pinhole aperture serves to:
A. Reduce background light and improve image clarity
B. Increase overall light intensity
C. Enable transmission of all emitted light
D. Increase field of view
Answer: A
Rationale: The pinhole filters out out-of-focus light, resulting in sharp optical sections and 3D
reconstruction capability.
4. Which of the following is a key advantage of phase-contrast microscopy?
A. Visualization of fluorescent markers
B. High-resolution surface imaging
C. Observation of living, unstained cells
D. Requires thin tissue sections
Answer: C
Rationale: Phase-contrast microscopy converts phase shifts in light passing through transparent
specimens into contrast, making live cells visible without staining.
5. The main limitation of light microscopy is:
A. Inability to image color
B. Poor depth perception
C. Resolution limited by the wavelength of light
