PHAR 505 EXAM 2 QUESTIONS WITH COMPLETE
SOLUTIONS 2025/26.
What are the sizings of the 5 main lipoproteins? Answer - HDL (Smallest)
LDL (medium)
VLDL (Large)
Chylomicrons (Very Large)
Which lipoprtein contains the most amount of cholesterol? Answer - LDL
Which lipoprotein is the most abundant in the bloodstream? Answer -
Chylomicron
What is the function of the B-100 protein? Answer - Serves in lipoprotein
recognition
Homozygous vs Heterozygous Familial Hypercholesterolemia Answer -
Homozygous = Non-functional LDL protein (High risk of mortality)
Heterozygous = Very high cholesterol
What are the three main ways we can help offset cholesterol? Answer - 1.
Reduced uptake from GI
2. Increased cholesterol catabolism
3. Reduced fat uptake from the GI
, Statins MOA Answer - inhibits HMG-CoA Reductase which causes less
cholesterol biosynthesis to occur and thus increase the amount of LDL
receptors on the surface
T or F Statins can be used in FH Answer - False! No synthesis of LDL and VLDL
receptors
What is considered the main pharmacophore of the statins Answer - Decalene
fragment
Lactone Fragment
Bile Acid Sequestrates MOA Answer - Sequestrates bile through a positively
charged ion and then gets rid of bile from there
Which drug class can be used with Familial Hypercholesterolemia? Answer -
PCSK-9 inhibitors
ASCVD Modifiable Risk Factors Answer - o Cigarette Smoking
o Hypertension
o Obesity
o Diabetes
o Physical inactivity
o High LDL
o Poor Diet
Optimal LDL Answer - 100
High LDL Answer - 160-189
SOLUTIONS 2025/26.
What are the sizings of the 5 main lipoproteins? Answer - HDL (Smallest)
LDL (medium)
VLDL (Large)
Chylomicrons (Very Large)
Which lipoprtein contains the most amount of cholesterol? Answer - LDL
Which lipoprotein is the most abundant in the bloodstream? Answer -
Chylomicron
What is the function of the B-100 protein? Answer - Serves in lipoprotein
recognition
Homozygous vs Heterozygous Familial Hypercholesterolemia Answer -
Homozygous = Non-functional LDL protein (High risk of mortality)
Heterozygous = Very high cholesterol
What are the three main ways we can help offset cholesterol? Answer - 1.
Reduced uptake from GI
2. Increased cholesterol catabolism
3. Reduced fat uptake from the GI
, Statins MOA Answer - inhibits HMG-CoA Reductase which causes less
cholesterol biosynthesis to occur and thus increase the amount of LDL
receptors on the surface
T or F Statins can be used in FH Answer - False! No synthesis of LDL and VLDL
receptors
What is considered the main pharmacophore of the statins Answer - Decalene
fragment
Lactone Fragment
Bile Acid Sequestrates MOA Answer - Sequestrates bile through a positively
charged ion and then gets rid of bile from there
Which drug class can be used with Familial Hypercholesterolemia? Answer -
PCSK-9 inhibitors
ASCVD Modifiable Risk Factors Answer - o Cigarette Smoking
o Hypertension
o Obesity
o Diabetes
o Physical inactivity
o High LDL
o Poor Diet
Optimal LDL Answer - 100
High LDL Answer - 160-189
