, Test Bank qy
to accompany
qy
Psychopharmacology, Fourth Edition qy qy
Meyer • Quenzer qy qy
Chapter 1: Principles of Pharmacology qy qy qy qy
Multiple Choice qy
1. refer(s) to specific molecular changes that occur when a drug binds to a
qy qy qy qy qy qy qy qy qy qy qy qy qy
particular target site or receptor, while
qy qy qy qy qy
are the resulting widespread alterations in function.
qy qy qy qy qy qy
a. Drug action; therapeutic effects
qy qy qy
b. Side effects; drug effects
qy qy qy
c. Therapeutic effects; side effects qy qy qy
d. Drug action; drug effects
qy qy qy
Answer: d qy
Textbook Reference: Pharmacology: The Science of Drug Action
qy qy qy qy qy qy qy
2. After drug administration has occurred, the amount of drug in the blood that is free
qy qy qy qy qy qy qy qy qy qy qy qy qy qy qy
to bind at specific target sites is referred to as
qy qy qy qy qy qy qy qy qy
a. the therapeutic dose.
qy qy
b. first-pass effects. qy
c. bioavailability.
d. ED50.
Answer: c qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
3. The specific molecular changes that occur when a drug binds to a particular target si
qy qy qy qy qy qy qy qy qy qy qy qy qy qy
te or receptor are referred to as
qy qy qy qy qy qy
a. drug effects.
qy
b. drug action. qy
c. side effects.
qy
d. placebo effects. qy
Answer: b qy
Textbook Reference: Pharmacology: The Science of Drug Action
qy qy qy qy qy qy qy
4. Which of the following is not a possible explanation for placebo effects?
qy qy qy qy qy qy qy qy qy qy qy
a. Pavlovian conditioning qy
b. Genetic variation qy
c. Drug competition
qy
d. Expectation of outcome qy qy
Answer: c qy
Textbook Reference: Pharmacology: The Science of Drug Action
qy qy qy qy qy qy qy
Page 1 of 247
qy qy qy
,5. The administration of oxytocin has been proposed as a treatment for autism. qy qy qy qy qy qy qy qy qy qy
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
6. Which factor does not affect the pharmacokinetics of a drug?
qy qy qy qy qy qy qy qy qy
a. Route of administration
qy qy
b. Lipid solubility
qy
c. Depot binding qy
d. Drug actionqy
Answer: d qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
7. First-pass metabolism occurs when drugs are taken
qy qy qy qy qy qy
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
8. The area postrema is one area in the brain where the
qy qy is not complete.
qy qy qy qy qy qy qy qy qy qy
a. cerebrospinal fluid qy
b. blood–brain barrier qy
c. choroid plexus qy
d. phospholipid membrane qy
Answer: b qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
9. First-pass metabolism occurs with orally administered drugs because
qy qy qy qy qy qy qy
a. their absorption is slowed by food.
qy qy qy qy qy
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way
qy qy qy qy qy qy qy qy qy qy qy qy qy qy q
to general circulation.
y qy qy
c. drugs must first survive the acidic environment of the stomach.
qy qy qy qy qy qy qy qy qy
d. salivary enzymes in the mouth begin the process of metabolism.
qy qy qy qy qy qy qy qy qy
Answer: b qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
10. Toxic substances in the blood trigger a vomiting response by activating the
qy qy qy qy qy qy qy qy qy qy qy
a. blood–brain barrier. qy
b. choroid plexus. qy
c. area postrema.
qy
d. median eminence. qy
Page 2 of 247
qy qy qy
, Answer: c qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
11. Drugs administered _ qy have the most rapid onset of action. qy qy qy qy qy qy qy
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
12. Ionization of a drug depends on the
qy of the solution and the
qy qy qy qy qy qy qy qy qy
of the drug.
qy qy
a. pH; pKa
qy
b. pKa; pH qy
c. concentration; lipid solubility qy qy
d. pH; concentration
qy
Answer: a qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
13. The absorption of a drug depends on all of the following except
qy qy qy qy qy qy qy qy qy qy qy
a. lipid solubility.
qy
b. ionization.
c. body temperature.
qy
d. the concentration of the drug.
qy qy qy qy
Answer: c qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
14. Drugs that are qyshould be avoided by women of childbearing age.
qy qy qy qy qy qy qy qy
a. teratogenic
b. able to cross the placental barrier
qy qy qy qy qy
c. psychoactive
d. highly lipid-soluble
qy
Answer: a qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
15. Agents that induce developmental abnormalities in a fetus are known as
qy qy qy qy qy qy qy qy qy qy
a. psychoactive drugs. qy
b. illicit drugs.
qy
c. teratogens.
d. placental drugs. qy
Answer: c qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
16. Depot binding is said to occur when drugs
qy qy qy qy qy qy qy
a. bind to their target sites.
qy qy qy qy
Page 3 of 247
qy qy qy
to accompany
qy
Psychopharmacology, Fourth Edition qy qy
Meyer • Quenzer qy qy
Chapter 1: Principles of Pharmacology qy qy qy qy
Multiple Choice qy
1. refer(s) to specific molecular changes that occur when a drug binds to a
qy qy qy qy qy qy qy qy qy qy qy qy qy
particular target site or receptor, while
qy qy qy qy qy
are the resulting widespread alterations in function.
qy qy qy qy qy qy
a. Drug action; therapeutic effects
qy qy qy
b. Side effects; drug effects
qy qy qy
c. Therapeutic effects; side effects qy qy qy
d. Drug action; drug effects
qy qy qy
Answer: d qy
Textbook Reference: Pharmacology: The Science of Drug Action
qy qy qy qy qy qy qy
2. After drug administration has occurred, the amount of drug in the blood that is free
qy qy qy qy qy qy qy qy qy qy qy qy qy qy qy
to bind at specific target sites is referred to as
qy qy qy qy qy qy qy qy qy
a. the therapeutic dose.
qy qy
b. first-pass effects. qy
c. bioavailability.
d. ED50.
Answer: c qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
3. The specific molecular changes that occur when a drug binds to a particular target si
qy qy qy qy qy qy qy qy qy qy qy qy qy qy
te or receptor are referred to as
qy qy qy qy qy qy
a. drug effects.
qy
b. drug action. qy
c. side effects.
qy
d. placebo effects. qy
Answer: b qy
Textbook Reference: Pharmacology: The Science of Drug Action
qy qy qy qy qy qy qy
4. Which of the following is not a possible explanation for placebo effects?
qy qy qy qy qy qy qy qy qy qy qy
a. Pavlovian conditioning qy
b. Genetic variation qy
c. Drug competition
qy
d. Expectation of outcome qy qy
Answer: c qy
Textbook Reference: Pharmacology: The Science of Drug Action
qy qy qy qy qy qy qy
Page 1 of 247
qy qy qy
,5. The administration of oxytocin has been proposed as a treatment for autism. qy qy qy qy qy qy qy qy qy qy
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
6. Which factor does not affect the pharmacokinetics of a drug?
qy qy qy qy qy qy qy qy qy
a. Route of administration
qy qy
b. Lipid solubility
qy
c. Depot binding qy
d. Drug actionqy
Answer: d qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
7. First-pass metabolism occurs when drugs are taken
qy qy qy qy qy qy
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
8. The area postrema is one area in the brain where the
qy qy is not complete.
qy qy qy qy qy qy qy qy qy qy
a. cerebrospinal fluid qy
b. blood–brain barrier qy
c. choroid plexus qy
d. phospholipid membrane qy
Answer: b qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
9. First-pass metabolism occurs with orally administered drugs because
qy qy qy qy qy qy qy
a. their absorption is slowed by food.
qy qy qy qy qy
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way
qy qy qy qy qy qy qy qy qy qy qy qy qy qy q
to general circulation.
y qy qy
c. drugs must first survive the acidic environment of the stomach.
qy qy qy qy qy qy qy qy qy
d. salivary enzymes in the mouth begin the process of metabolism.
qy qy qy qy qy qy qy qy qy
Answer: b qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
10. Toxic substances in the blood trigger a vomiting response by activating the
qy qy qy qy qy qy qy qy qy qy qy
a. blood–brain barrier. qy
b. choroid plexus. qy
c. area postrema.
qy
d. median eminence. qy
Page 2 of 247
qy qy qy
, Answer: c qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
11. Drugs administered _ qy have the most rapid onset of action. qy qy qy qy qy qy qy
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
12. Ionization of a drug depends on the
qy of the solution and the
qy qy qy qy qy qy qy qy qy
of the drug.
qy qy
a. pH; pKa
qy
b. pKa; pH qy
c. concentration; lipid solubility qy qy
d. pH; concentration
qy
Answer: a qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
13. The absorption of a drug depends on all of the following except
qy qy qy qy qy qy qy qy qy qy qy
a. lipid solubility.
qy
b. ionization.
c. body temperature.
qy
d. the concentration of the drug.
qy qy qy qy
Answer: c qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
14. Drugs that are qyshould be avoided by women of childbearing age.
qy qy qy qy qy qy qy qy
a. teratogenic
b. able to cross the placental barrier
qy qy qy qy qy
c. psychoactive
d. highly lipid-soluble
qy
Answer: a qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
15. Agents that induce developmental abnormalities in a fetus are known as
qy qy qy qy qy qy qy qy qy qy
a. psychoactive drugs. qy
b. illicit drugs.
qy
c. teratogens.
d. placental drugs. qy
Answer: c qy
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
qy qy qy qy qy qy
16. Depot binding is said to occur when drugs
qy qy qy qy qy qy qy
a. bind to their target sites.
qy qy qy qy
Page 3 of 247
qy qy qy
