GMS 6552 Problem Sets REVIEW |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
EXAM 1 WITH CORRECT ANSWERS |||\\\ |||\\\ |||\\\ |||\\\
Which type of receptor most often utilizes second-messenger systems in its signaling?
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Kinase-linked receptors |||\\\
Channel-linked receptors |||\\\
Nuclear receptors |||\\\
G-protein coupled receptors - correct answer✔✔G-protein coupled receptors
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Assume you have receptor antagonists that are able to stop receptor signaling immediately. For
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
which type of receptor would it take the longest to see the effects of your drug at the cellular
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
level?
Kinase-linked receptors |||\\\
Channel-linked receptors |||\\\
Nuclear receptors |||\\\
G-protein coupled receptors - correct answer✔✔Nuclear receptors
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
For which type of receptor would having adequate membrane permeability of an agonist be
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
most critical? |||\\\
Kinase-linked receptors |||\\\
Channel-linked receptors |||\\\
Nuclear receptors |||\\\
G-protein coupled receptors - correct answer✔✔Nuclear receptors
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
, Is it more likely for a G-protein coupled receptor agonist to bind near the N- or C- terminus of
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
the receptor?
|||\\\
N-terminus
C-terminus - correct answer✔✔N-terminus |||\\\ |||\\\ |||\\\ |||\\\
Is it more likely to find a GPCR bound to a G-protein that is also bound to GTP or GDP?
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
GTP
GDP - correct answer✔✔GDP
|||\\\ |||\\\ |||\\\ |||\\\
Which protein ultimately is translocated from the cytoplasm to the nucleus as a result of JAK
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
signaling?
JAK
GRB2
SH2
PI3K
STAT - correct answer✔✔STAT
|||\\\ |||\\\ |||\\\ |||\\\
Where, in relation to the protein-coding region of a gene, are the binding sites that become
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
occupied by nuclear receptors? |||\\\ |||\\\ |||\\\
Upstream
Within the coding region |||\\\ |||\\\ |||\\\
Downstream - correct answer✔✔Upstream |||\\\ |||\\\ |||\\\ |||\\\
EXAM 1 WITH CORRECT ANSWERS |||\\\ |||\\\ |||\\\ |||\\\
Which type of receptor most often utilizes second-messenger systems in its signaling?
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
Kinase-linked receptors |||\\\
Channel-linked receptors |||\\\
Nuclear receptors |||\\\
G-protein coupled receptors - correct answer✔✔G-protein coupled receptors
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
Assume you have receptor antagonists that are able to stop receptor signaling immediately. For
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
which type of receptor would it take the longest to see the effects of your drug at the cellular
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
level?
Kinase-linked receptors |||\\\
Channel-linked receptors |||\\\
Nuclear receptors |||\\\
G-protein coupled receptors - correct answer✔✔Nuclear receptors
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
For which type of receptor would having adequate membrane permeability of an agonist be
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
most critical? |||\\\
Kinase-linked receptors |||\\\
Channel-linked receptors |||\\\
Nuclear receptors |||\\\
G-protein coupled receptors - correct answer✔✔Nuclear receptors
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
, Is it more likely for a G-protein coupled receptor agonist to bind near the N- or C- terminus of
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
the receptor?
|||\\\
N-terminus
C-terminus - correct answer✔✔N-terminus |||\\\ |||\\\ |||\\\ |||\\\
Is it more likely to find a GPCR bound to a G-protein that is also bound to GTP or GDP?
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
GTP
GDP - correct answer✔✔GDP
|||\\\ |||\\\ |||\\\ |||\\\
Which protein ultimately is translocated from the cytoplasm to the nucleus as a result of JAK
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
signaling?
JAK
GRB2
SH2
PI3K
STAT - correct answer✔✔STAT
|||\\\ |||\\\ |||\\\ |||\\\
Where, in relation to the protein-coding region of a gene, are the binding sites that become
|||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\ |||\\\
occupied by nuclear receptors? |||\\\ |||\\\ |||\\\
Upstream
Within the coding region |||\\\ |||\\\ |||\\\
Downstream - correct answer✔✔Upstream |||\\\ |||\\\ |||\\\ |||\\\
