,Table of Contents
UNIT I: INTRODUCTION .............................................................. 6
Chapter 1: Orientation To Pharmacology............................................. 6
Chapter 2: Application Of Pharmacology In Nursing Practice............. 9
Chapter 3: Drug Regulation, Development, Names, And Information.. 15
UNIT II: BASIC PRINCIPLES OF PHARMACOLOGY ........................... 19
Chapter 4: Pharmacokinetics .................................................... 19
Chapter 5: Pharmacodynamics .......26
Chapter 6: Drug Interactions ......... 30
Chapter 7: Adverse Drug Reactions And Medication Errors ....... 37
Chapter 8: Individual Variation In Drug Responses ......... 44
UNIT III: DRUG THERAPY ACROSS THE LIFE SPAN.... 50
Chapter 9: Drug Therapy During Pregnancy And Breast-Feeding .... 50
Chapter 10: Drug Therapy In Pediatric Patients ..... 55
Chapter 11: Drug Therapy In Geriatric Patients .... 60
UNIT IV: PERIPHERAL NERVOUS SYSTEM DRUGS ...... 67
Section 1: Introduction .. 67
Chapter 12: Basic Principles Of Neuropharmacology ... 67
Chapter 13: Physiology Of The Peripheral Nervous System .... 71
Section 2: Cholinergic Drugs ........ 76
Chapter 14: Muscarinic Agonists And Antagonists .... 76
Chapter 15: Cholinesterase Inhibitors And Their Use In Myasthenia Gravis .... 81
Chapter 16: Drugs That Block Nicotinic Cholinergic Transmission: Neuromuscular
Blocking Agents And Ganglionic Blocking Agents ... 87
Section 3: Adrenergic Drugs ....... 93
Chapter 17: Adrenergic Agonists ..... . 93
,Chapter 18: Adrenergic Antagonists ... 100
Chapter 19: Indirect-Acting Antiadrenergic Agents .... 108
Unit V: Central Nervous System Drugs .. 114
Section 4: Introduction ............................ 114
Chapter 20: Introduction To Central Nervous System Pharmacology
............................................ 114
Section 5: Drugs for Neurodegenerative Disorders
.......................................................................... 118
Chapter 21: Drugs For Parkinson’s Disease
...................................................................................... 118
Chapter 22: Alzheimer’s Disease
.................................................................................................. 125
Chapter 23: Drugs For Multiple Sclerosis ......... 131
Section 6: Neurologic Drugs ................. 137
Chapter 24: Drugs For Seizure Disorders ........ 137
Chapter 25: Drugs For Muscle Spasm And Spasticity ....... 147
Section 7: Drugs for Pain ........................... 152
Chapter 26: Local Anesthetics ................ 152
Chapter 27: General Anesthetics ........... 158
Chapter 28: Opioid (Narcotic) Analgesics, Opioid Antagonists, And Nonopioid Centrally
Acting Analgesics ......................................... 165
Chapter 29: Pain Management In Patients With Cancer ....... 173
Chapter 30: Drugs For Headache ........ 182
Section 8: Psychotherapeutic Drugs ........... 188
Chapter 31: Antipsychotic Agents And Their Use In Schizophrenia
.............................................. 188
Chapter 32: Antidepressants ........................................... 196
Chapter 33: Drugs For Bipolar Disorder ............. 206
Chapter 34: Sedative-Hypnotic Drugs ............... 212
, Chapter 35: Central Nervous System Stimulants And Attention-Deficit/Hyperactivity
Disorder .......... 226
Section 9: Drug Abuse .................................... 233
Chapter 37: Substance Use Disorders I: Basic Considerations
....................................................... 233
Chapter 38: Substance Use Disorders II: Alcohol
............................................................................ 237
Chapter 39: Substance Use Disorders III: Nicotine And Smoking
.................................................. 246
Chapter 40: Substance Use Disorders IV: Major Drugs Of Abuse Other Than Alcohol And
Nicotine ........................................................... 252
UNIT VI: DRUGS THAT AFFECT FLUID AND ELECTROLYTE BALANCE
.................................... 262
Chapter 41: Diuretics ...................... 262
Chapter 42: Agents Affecting The Volume And Ion Content Of Body Fluids
................................ 268
UNIT VII: DRUGS THAT AFFECT THE HEART, BLOOD VESSELS, AND BLOOD
......................... 275
Chapter 43: Review Of Hemodynamics
.......................................................................................... 275
Chapter 44: Drugs Acting On The Renin–Angiotensin–Aldosterone System
............................... 279
Chapter 45: Calcium Channel Blockers ............. 286
Chapter 46: Vasodilators ..................... 291
Chapter 47: Drugs For Hypertension .............. 296
Chapter 48: Drugs For Heart Failure ........... 306
Chapter 49: Antidysrhythmic Drugs ......... 318
Chapter 50: Prophylaxis Of Coronary Heart Disease: Drugs That Help Normalize
Cholesterol And Triglyceride Levels ................................ 329
UNIT I: INTRODUCTION .............................................................. 6
Chapter 1: Orientation To Pharmacology............................................. 6
Chapter 2: Application Of Pharmacology In Nursing Practice............. 9
Chapter 3: Drug Regulation, Development, Names, And Information.. 15
UNIT II: BASIC PRINCIPLES OF PHARMACOLOGY ........................... 19
Chapter 4: Pharmacokinetics .................................................... 19
Chapter 5: Pharmacodynamics .......26
Chapter 6: Drug Interactions ......... 30
Chapter 7: Adverse Drug Reactions And Medication Errors ....... 37
Chapter 8: Individual Variation In Drug Responses ......... 44
UNIT III: DRUG THERAPY ACROSS THE LIFE SPAN.... 50
Chapter 9: Drug Therapy During Pregnancy And Breast-Feeding .... 50
Chapter 10: Drug Therapy In Pediatric Patients ..... 55
Chapter 11: Drug Therapy In Geriatric Patients .... 60
UNIT IV: PERIPHERAL NERVOUS SYSTEM DRUGS ...... 67
Section 1: Introduction .. 67
Chapter 12: Basic Principles Of Neuropharmacology ... 67
Chapter 13: Physiology Of The Peripheral Nervous System .... 71
Section 2: Cholinergic Drugs ........ 76
Chapter 14: Muscarinic Agonists And Antagonists .... 76
Chapter 15: Cholinesterase Inhibitors And Their Use In Myasthenia Gravis .... 81
Chapter 16: Drugs That Block Nicotinic Cholinergic Transmission: Neuromuscular
Blocking Agents And Ganglionic Blocking Agents ... 87
Section 3: Adrenergic Drugs ....... 93
Chapter 17: Adrenergic Agonists ..... . 93
,Chapter 18: Adrenergic Antagonists ... 100
Chapter 19: Indirect-Acting Antiadrenergic Agents .... 108
Unit V: Central Nervous System Drugs .. 114
Section 4: Introduction ............................ 114
Chapter 20: Introduction To Central Nervous System Pharmacology
............................................ 114
Section 5: Drugs for Neurodegenerative Disorders
.......................................................................... 118
Chapter 21: Drugs For Parkinson’s Disease
...................................................................................... 118
Chapter 22: Alzheimer’s Disease
.................................................................................................. 125
Chapter 23: Drugs For Multiple Sclerosis ......... 131
Section 6: Neurologic Drugs ................. 137
Chapter 24: Drugs For Seizure Disorders ........ 137
Chapter 25: Drugs For Muscle Spasm And Spasticity ....... 147
Section 7: Drugs for Pain ........................... 152
Chapter 26: Local Anesthetics ................ 152
Chapter 27: General Anesthetics ........... 158
Chapter 28: Opioid (Narcotic) Analgesics, Opioid Antagonists, And Nonopioid Centrally
Acting Analgesics ......................................... 165
Chapter 29: Pain Management In Patients With Cancer ....... 173
Chapter 30: Drugs For Headache ........ 182
Section 8: Psychotherapeutic Drugs ........... 188
Chapter 31: Antipsychotic Agents And Their Use In Schizophrenia
.............................................. 188
Chapter 32: Antidepressants ........................................... 196
Chapter 33: Drugs For Bipolar Disorder ............. 206
Chapter 34: Sedative-Hypnotic Drugs ............... 212
, Chapter 35: Central Nervous System Stimulants And Attention-Deficit/Hyperactivity
Disorder .......... 226
Section 9: Drug Abuse .................................... 233
Chapter 37: Substance Use Disorders I: Basic Considerations
....................................................... 233
Chapter 38: Substance Use Disorders II: Alcohol
............................................................................ 237
Chapter 39: Substance Use Disorders III: Nicotine And Smoking
.................................................. 246
Chapter 40: Substance Use Disorders IV: Major Drugs Of Abuse Other Than Alcohol And
Nicotine ........................................................... 252
UNIT VI: DRUGS THAT AFFECT FLUID AND ELECTROLYTE BALANCE
.................................... 262
Chapter 41: Diuretics ...................... 262
Chapter 42: Agents Affecting The Volume And Ion Content Of Body Fluids
................................ 268
UNIT VII: DRUGS THAT AFFECT THE HEART, BLOOD VESSELS, AND BLOOD
......................... 275
Chapter 43: Review Of Hemodynamics
.......................................................................................... 275
Chapter 44: Drugs Acting On The Renin–Angiotensin–Aldosterone System
............................... 279
Chapter 45: Calcium Channel Blockers ............. 286
Chapter 46: Vasodilators ..................... 291
Chapter 47: Drugs For Hypertension .............. 296
Chapter 48: Drugs For Heart Failure ........... 306
Chapter 49: Antidysrhythmic Drugs ......... 318
Chapter 50: Prophylaxis Of Coronary Heart Disease: Drugs That Help Normalize
Cholesterol And Triglyceride Levels ................................ 329
