COMLEX LEVEL 1 EXAM 2025/2026 UPDATED PRACTICE
QUESTIONS AND CORRECT DEFINITIVE ANSWERS (COMPLETE
SOLUTIONS) ASSURED SUCCESS RATED A+
Pericarditis
EKG presents with PR depression, ST segment elevation and PR
elevation in lead II. They also have sharp, midsternal, non-
radiating chest pain and mild lethargy. What do they have?
Bottom rib in ISD/ Top rib in ESD
BITE mnemonic is used for rib dysfunction treatments, what is it?
Pectoralis minor muscle
What muscle connects to ribs 3-5?
Rib dysfunctions are named by where they are stuck while rib
restrictions are named by which motion they do not experience!
How are rib dysfunctions named and how do they differ from rib
restrictions?
Decreases due to decreased transport
In Wilson's disease there is a decrease in copper exportation
which results in low biliary copper, what happens to the
transport protein ceruloplasmin?
,Digoxin
Positive inotrope for a failing heart
Inhibits Na/K Atpase pumps and causes an increase in
intracellular Ca2+ while also causing parasympathetic effects
ADR: has a narrow therapeutic window and can cause GI
distress, visual disturbances, AV Block and bradycardia
Mercury poisoning
Patient went on a seafood binge for a few days at a shady
restaurant and present to the hospital with neurotoxicity and
acute renal injury which presents as tremors or oliguria and
elevated creatinine
Methanol poisoning
Symptoms: Severe metabolic acidosis, retinal damage
(blindness). Lab Values: Pathophysiology: Toxicity via formic acid.
Severe acidosis, retinal damage. Treatment: Ethanol, dialysis,
fomepizole.
Pilocarpine
Muscarinic agonist
Use: contracts ciliary muscle to help increase the outflow of
aqueous humor at the canal of schlem--> Used to treat glaucoma
,Side note: Beta blockers are used to decrease production of
aqueous humor to decrease intra-ocular pressure
Rationalization
Defense mechanism that offers rational explanations in an
attempt to justify attitudes, beliefs, or behaviors that may
otherwise be unacceptable
Factitious disorder
Condition in which a person acts as if he or she has a physical or
mental illness when he or she is not really sick
Caveat: the symptoms don't interfere with daily life--> if it does
and the symptoms are very severe it is somatic symptom
disorder
Subacute sclerosing panencephalitis
Serious complication of the measles virus that usually develops
6-10 years after infection
Anterior talofibular ligament (lateral ligament)
Inversion sprain, "Low ankle sprain", most common
-pain with inversion of foot and dorsiflexion
, Gemfibrozil
MOA: enhances LPL and hydrolyzes fatty acid from VLDL
-enhances uptake of fatty acids and increases conversion into
Triglycerides which leads to less triglycerides in the serum
Ebola virus
Filovirus
-enveloped nonsegmented negative sense RNA genome
-one of the most virulent pathogen of humans, endemic to West
Africa
-infections culminate into multiple organ failure dysfunction
syndrome and shock due to production of high levels of
inflammatory cytokines in response to infection
Amytriptyline
Post herpetic neuralgia treatment
Bactericides fragility and fusobacterium species
Gram negative rods grown on aerobic media that can cause
infectious sinusitis
Tx: clindamycin
Acute chest syndrome
QUESTIONS AND CORRECT DEFINITIVE ANSWERS (COMPLETE
SOLUTIONS) ASSURED SUCCESS RATED A+
Pericarditis
EKG presents with PR depression, ST segment elevation and PR
elevation in lead II. They also have sharp, midsternal, non-
radiating chest pain and mild lethargy. What do they have?
Bottom rib in ISD/ Top rib in ESD
BITE mnemonic is used for rib dysfunction treatments, what is it?
Pectoralis minor muscle
What muscle connects to ribs 3-5?
Rib dysfunctions are named by where they are stuck while rib
restrictions are named by which motion they do not experience!
How are rib dysfunctions named and how do they differ from rib
restrictions?
Decreases due to decreased transport
In Wilson's disease there is a decrease in copper exportation
which results in low biliary copper, what happens to the
transport protein ceruloplasmin?
,Digoxin
Positive inotrope for a failing heart
Inhibits Na/K Atpase pumps and causes an increase in
intracellular Ca2+ while also causing parasympathetic effects
ADR: has a narrow therapeutic window and can cause GI
distress, visual disturbances, AV Block and bradycardia
Mercury poisoning
Patient went on a seafood binge for a few days at a shady
restaurant and present to the hospital with neurotoxicity and
acute renal injury which presents as tremors or oliguria and
elevated creatinine
Methanol poisoning
Symptoms: Severe metabolic acidosis, retinal damage
(blindness). Lab Values: Pathophysiology: Toxicity via formic acid.
Severe acidosis, retinal damage. Treatment: Ethanol, dialysis,
fomepizole.
Pilocarpine
Muscarinic agonist
Use: contracts ciliary muscle to help increase the outflow of
aqueous humor at the canal of schlem--> Used to treat glaucoma
,Side note: Beta blockers are used to decrease production of
aqueous humor to decrease intra-ocular pressure
Rationalization
Defense mechanism that offers rational explanations in an
attempt to justify attitudes, beliefs, or behaviors that may
otherwise be unacceptable
Factitious disorder
Condition in which a person acts as if he or she has a physical or
mental illness when he or she is not really sick
Caveat: the symptoms don't interfere with daily life--> if it does
and the symptoms are very severe it is somatic symptom
disorder
Subacute sclerosing panencephalitis
Serious complication of the measles virus that usually develops
6-10 years after infection
Anterior talofibular ligament (lateral ligament)
Inversion sprain, "Low ankle sprain", most common
-pain with inversion of foot and dorsiflexion
, Gemfibrozil
MOA: enhances LPL and hydrolyzes fatty acid from VLDL
-enhances uptake of fatty acids and increases conversion into
Triglycerides which leads to less triglycerides in the serum
Ebola virus
Filovirus
-enveloped nonsegmented negative sense RNA genome
-one of the most virulent pathogen of humans, endemic to West
Africa
-infections culminate into multiple organ failure dysfunction
syndrome and shock due to production of high levels of
inflammatory cytokines in response to infection
Amytriptyline
Post herpetic neuralgia treatment
Bactericides fragility and fusobacterium species
Gram negative rods grown on aerobic media that can cause
infectious sinusitis
Tx: clindamycin
Acute chest syndrome
