NBME 28 Exam Questions and Answers

9/26/25, 3:34 PM NBME 28 <span style="color:#000;font-weight:bold;">160+</span> (2025-2026 A+ Graded) Exam-Style Questions | Verified Solutio…




NBME 28 Exam Questions and Answers
Question 1
Which sensory information is compromised by the anterior lobe of the superior
cerebellum?
Correct Answer
unconscious proprioception



Question 2
What controls conscious proprioception?
Correct Answer
DCML



Question 3
Lesion in this part of the cerebellum can cause broad based ataxia
Correct Answer
anterior lobe



Question 4
Conscious proprioception, 2 point discrimination and _______ is also mediated by the
DMCL
Correct Answer
vibration sense



Question 5
Synthesis of enzymes necessary for replication of genome occurs in which phase of
the cell cycle?
Correct Answer
G1 (because DNA gets duplicated after in S phase)




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,9/26/25, 3:34 PM NBME 28 <span style="color:#000;font-weight:bold;">160+</span> (2025-2026 A+ Graded) Exam-Style Questions | Verified Solutio…




Question 6
Does proteins synthesis occur in M phase?
Correct Answer
no



Question 7
This is the phase of cell where DNA replication occurs
Correct Answer
S phase



Question 8
This is the phase where integrity of duplicated genome is checked and corrected.
Correct Answer
G2



Question 9
G2 phase is also where phase of growth and ________ synthesis takes place in
preparation for the phases of mitosis and cell division
Correct Answer
protein



Question 10
When looking at a serum [PAH] vs. PAH secretion rate graph, there is an inflection
point where secretion rate plateaus, which means the clearance of PAH does not
increase (slope 0).

Before this inflection point, the clearance of PAH is higher (slope >0).

This means that on the plateau area, PAH clearance is ______ than it is in the ascending
area.
Correct Answer
lower




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Question 11
What sequence encods the polyadenylation signal?
Correct Answer
AATAAA



Question 12
Where do splice sites exist?
Correct Answer
At the end of an intron and beginning of an exon



Question 13
Mutations in the _____ region are known to cause beta thalassemia.
Correct Answer
promoter



Question 14
Capping with GTP occurs at the beginning of trasncription at the ________.
Correct Answer
5' end of the nascent mRNA



Question 15
Capping with GTP at the 5' end of nascent mRNA is recognized by ______ in cytoplasm
and facilitates initation of translation.
Correct Answer
ribosomes




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, 9/26/25, 3:34 PM NBME 28 <span style="color:#000;font-weight:bold;">160+</span> (2025-2026 A+ Graded) Exam-Style Questions | Verified Solutio…




Question 16
A mutation in GTP cap would result in synthesis of normal mRNA transcript but failure
of _________.
Correct Answer
translation



Question 17
A 5 yr old girl has precocious puberty. Pelvic exam shows a mass consistent with
ovarian tumor. Sstudies show decreased gonadotropins and marked increase in
estrogens.

What is the ovarian tumor derived from most likely?
Correct Answer
Granulosa



Question 18
_____ tumors also produce estrogen and androgen like granulosa tumors and may
present with postmenopausal bleeding but are less common than granulosa tumors.
Correct Answer
thecal



Question 19
An old patient with fever, chills, tachycardia, hypotension and finally shock grows E.
coli.

What is the most likely initial cause of the hypotension?
Correct Answer

Excessive production of nitric oxide

Note that this is not caused by hemorrhage because our patient's abdominal pain is
most likely d/t infectious enteritis and less likely from an abdominal aortic
aneurysm.




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