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Summary

Samenvatting Overzicht antimycotica algemene microbiologie.

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Overzicht antimycotica algemene microbiologie.

Institution
Universiteit Gent (UGent)
Course
Algemene microbiologie (J000504A)

Content preview

Klasse Subklasse/ Structuur Werking Resistentie Extra
voorbeelden
Inhibitie ergosterol biosynthese

Azolen 1. Imidazolen 1. Imidazole - Inhibitie lanosterol 14-alfa- - Efflux
Miconazole, demethylase (ERG11) - Overexpressie ERG
ketoconazole 11 ( & andere genen)
2. Triazolen betrokken bij
Fluconazole, ergosterol
itraconazole biosynthese
- Mutaties in ERG 11
 verminderde
affiniteit vr azolen
2. Triazole




Allylamines - Terbinafine - Allyl + amine - Inhibitie squaleen epoxidae - Terbinafine: lokale
(ERG1) behandeling
oppervlakkige
huidinfecties &
onychomycosen

Morfoline - Amorolfine - Morfoline - Inhibitie lanosterol 14-alfa- - Overexpressie ERG - Amorolfine: als
derivaten demethylase (ERG11) 11 ( & andere genen) nagellak voor
- Inhibitie C-24 sterol methyl- betrokken bij behandeling
transferase (ERG6) ergosterol onychomycose
biosynthese
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Institution
Universiteit Gent (UGent)
Study
Farmaceutische Wetenschappen
Course
Algemene microbiologie (J000504A)
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Uploaded on
September 24, 2025
Number of pages
3
Written in
2024/2025
Type
SUMMARY

Subjects

  • antimycotica
  • microbiologie
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