WGU D116 UNIT 8 OA REVIEW
QUESTIONS & ANSWERS|| 2025
LATEST UPDATE|| VERIFIED
A nursing student asks for clarification on the differences between the mechanisms of
spontaneous mutation and conjugation in acquired resistance of microbes.
Which statement is correct? - ANSWERSpontaneous mutation leads to resistance to
only one antimicrobial agent
A patient receiving a cephalosporin develops a secondary intestinal infection caused by
Clostridium difficile.
What is an appropriate treatment for this patient? - ANSWERDiscontinuing the
cephalosporin and beginning flagyl
A patient is diagnosed with a lung infection caused by Pseudomonas aeruginosa. The
culture and sensitivity report shows sensitivity to all aminoglycosides. The provider
knows that the rate of resistance to gentamicin is common in this hospital.
Which medication should the provider be expected to order? - ANSWERAmikacin
When resistance to gentamicin and tobramycin is common, amikacin is the drug of
choice for the initial treatment of aminoglycoside-sensitive infections
A child with otitis media has had three ear infections in the past year. The child has just
completed a ten-day course of amoxicillin with no improvement. The parent asks the
provider why this drug is not working because it has worked in the past.
What should the provider tell the patient? - ANSWER"The bacteria have synthesized
penicillinase"
Beta-lactamases are enzymes that cleave the beta-lactam ring and render the PCN
inactive (amoxicillin)
Pt will need to start augmentin
A patient who is taking acetaminophen for pain wants to know why it does not cause
gastrointestinal upset as other over-the-counter pain medications do.
Which property of acetaminophen is the most likely explanation for this? - ANSWERIt
has minimal effects at peripheral sites
Tylenol central effects
NSAIDs peripheral effects
, A patient who has arthritis has been taking ibuprofen and a glucocorticoid medication.
The patient reports having tarry stools but denies gastric pain.
Which action by the provider is correct? - ANSWERPrescribing an antiulcer medication
Glucocorticoid therapy, especially when combined with NSAIDs, can increase the risk of
gastric ulcer and possibly bleeding
A patient will begin taking hydroxychloroquine for rheumatoid arthritis. The patient is
currently taking high-dose NSAIDs and methotrexate.
What should the patient be taught about hydroxychloroquine? - ANSWERAn eye exam
is necessary at the beginning of therapy with this drug
Can cause retinal damage - eye exam at the onset of treatment as well as every 6
months during treatment
A patient with gout who has increasingly frequent acute gouty attacks will begin
receiving allopurinol and colchicine.
Which statement should be included when teaching the patient about this drug
regimen? - ANSWER"You will take both drugs initially and then stop taking colchicine"
Colchicine is used for prophylaxis when urate-lowering drugs (allopurinal) are initiated
because gouty episodes often increase during this time.
A postmenopausal patient develops osteoporosis. The patient asks the provider about
medications to treat this condition. The provider learns that the patient has a family
history of breast cancer.
Which medication should the provider discuss with the patient? - ANSWERRaloxifene
Can preserve bone mineral density while protecting against breast and endometrial
cancers
Which of the following antibiotics is in a class of drugs known for ototoxicity? -
ANSWERGentamicin
Aminoglycoside abx which as a class are known to cause ototoxicity
What is the role of oral corticosteroids in the treatment of rheumatoid arthritis? -
ANSWERShort-term therapy for flares in pts with established disease - slows the
progression of erosions
What is a recommended strategy for patients to do prior to injecting disease-modifying
antirheumatic drugs (DMARDs) to decrease the pain of the injection? - ANSWERAllow
injection to come to room temperature
DMARDs are refrigerated
QUESTIONS & ANSWERS|| 2025
LATEST UPDATE|| VERIFIED
A nursing student asks for clarification on the differences between the mechanisms of
spontaneous mutation and conjugation in acquired resistance of microbes.
Which statement is correct? - ANSWERSpontaneous mutation leads to resistance to
only one antimicrobial agent
A patient receiving a cephalosporin develops a secondary intestinal infection caused by
Clostridium difficile.
What is an appropriate treatment for this patient? - ANSWERDiscontinuing the
cephalosporin and beginning flagyl
A patient is diagnosed with a lung infection caused by Pseudomonas aeruginosa. The
culture and sensitivity report shows sensitivity to all aminoglycosides. The provider
knows that the rate of resistance to gentamicin is common in this hospital.
Which medication should the provider be expected to order? - ANSWERAmikacin
When resistance to gentamicin and tobramycin is common, amikacin is the drug of
choice for the initial treatment of aminoglycoside-sensitive infections
A child with otitis media has had three ear infections in the past year. The child has just
completed a ten-day course of amoxicillin with no improvement. The parent asks the
provider why this drug is not working because it has worked in the past.
What should the provider tell the patient? - ANSWER"The bacteria have synthesized
penicillinase"
Beta-lactamases are enzymes that cleave the beta-lactam ring and render the PCN
inactive (amoxicillin)
Pt will need to start augmentin
A patient who is taking acetaminophen for pain wants to know why it does not cause
gastrointestinal upset as other over-the-counter pain medications do.
Which property of acetaminophen is the most likely explanation for this? - ANSWERIt
has minimal effects at peripheral sites
Tylenol central effects
NSAIDs peripheral effects
, A patient who has arthritis has been taking ibuprofen and a glucocorticoid medication.
The patient reports having tarry stools but denies gastric pain.
Which action by the provider is correct? - ANSWERPrescribing an antiulcer medication
Glucocorticoid therapy, especially when combined with NSAIDs, can increase the risk of
gastric ulcer and possibly bleeding
A patient will begin taking hydroxychloroquine for rheumatoid arthritis. The patient is
currently taking high-dose NSAIDs and methotrexate.
What should the patient be taught about hydroxychloroquine? - ANSWERAn eye exam
is necessary at the beginning of therapy with this drug
Can cause retinal damage - eye exam at the onset of treatment as well as every 6
months during treatment
A patient with gout who has increasingly frequent acute gouty attacks will begin
receiving allopurinol and colchicine.
Which statement should be included when teaching the patient about this drug
regimen? - ANSWER"You will take both drugs initially and then stop taking colchicine"
Colchicine is used for prophylaxis when urate-lowering drugs (allopurinal) are initiated
because gouty episodes often increase during this time.
A postmenopausal patient develops osteoporosis. The patient asks the provider about
medications to treat this condition. The provider learns that the patient has a family
history of breast cancer.
Which medication should the provider discuss with the patient? - ANSWERRaloxifene
Can preserve bone mineral density while protecting against breast and endometrial
cancers
Which of the following antibiotics is in a class of drugs known for ototoxicity? -
ANSWERGentamicin
Aminoglycoside abx which as a class are known to cause ototoxicity
What is the role of oral corticosteroids in the treatment of rheumatoid arthritis? -
ANSWERShort-term therapy for flares in pts with established disease - slows the
progression of erosions
What is a recommended strategy for patients to do prior to injecting disease-modifying
antirheumatic drugs (DMARDs) to decrease the pain of the injection? - ANSWERAllow
injection to come to room temperature
DMARDs are refrigerated
