Test Bank For Cellular and Molecular Immunology, 11th Edition by Abul K. Abbas| Verified Chapters 1-21|| Latest Edition 2025

,Table of Contents
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Chapter 01 Properties and Overview of Immune Responses
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Chapter 02 Cells and Tissues of the Immune System
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Chapter 03 Leukocyte Circulation and Migration Into Tissues
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Chapter 04 Innate Immunity
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Chapter 05 Antibodies and Antigens
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Chapter 06 Antigen Presentation to T Lymphocytes and the Fu tions of Major
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Histocompatibility Complex Molecules kj kj 20
Chapter 07 Immune Receptors and Signal Transduction
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Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
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Chapter 09 Activation of T Lymphocytes
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Chapter 10 Differentiation and Fu tions of CD4+ Effector T Cells
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Chapter 11 Differentiation and Fu tions of CD8+ Effector T Cells
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Chapter 12 B Cell Activation and Antibody Production
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Chapter 13 Effector Mechanisms of Humoral Immunity
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Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
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Chapter 15 Immunologic Tolera e and Autoimmunity
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Chapter 16 Immunity to Microbes
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Chapter 17 Transplantation Immunology
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Chapter 18 Tumor Immunology
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Chapter 19 Hypersensitivity Disorders
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Chapter 20 Allergy
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Chapter 21 Primary and Acquired Immunodeficie ies
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,Chapter 01: Properties and Overview of Immune Responses
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Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 11th Edition
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MULTIPLE CHOICE kj




1. The pri ipal fu tion of the immune system is:
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a. Defense against ca er kj kj kj


b. Repair of injured tissues kj kj kj


c. Defense against microbial infections kj kj kj


d. Prevention of inflammatory diseases kj kj kj


e. Protection against environmental toxins kj kj kj




ANS: C k j


The immune system has evolved in the setting of selective pressures imposed by microbial
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infections. Although immune responses to ca er may occur, the co ept that ―immunosurveil
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la e‖ against ca er is a pri ipal fu tion of the immune system is controversial. Repair of inju
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red tissues may be a secondary conseque e of the immune responses and inflammation. Alt
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hough the immune system has regulatory features that are needed to prevent excessive infl
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ammation, prevention of inflammatory diseases is not a primary fu tion. The immune syste
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m can protect against microbial toxins, but it generally does not offer protection against toxi
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ns of nonbiologic origin.
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2. Which of the following infectious diseases was prevented by the first successful
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vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C k j


In 1798, Edward Jenner reported the first intentional successful vaccination, which was ag
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ainst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980, s
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mallpox was reported to be eradicated worldwide by a vaccination program. Effective vacc
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ines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th century
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and are widely used. There is no effective vaccine against Mycobacterium tuberculosis.
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3. Which of the following is a unique property of the adaptive immune system?
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a. Highly diverse repertoire of specificities for antigens kj kj kj kj kj kj


b. Self-nonself discrimination kj


c. Recognition of microbial structures by both cell-associated and soluble receptors kj kj kj kj kj kj kj kj kj


d. Protection against viral infections kj kj kj


e. Responses that have the same kinetics and magnitude on repeated exposure to the kj kj kj kj kj kj kj kj kj kj kj kj kj


same microbe kj




ANS: k j A

, Highly diverse repertoires of specificities for antigens are found only in T and B lymphocy
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tes, which are the central cellular components of the adaptive immune system. Both the inn
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ate and the adaptive immune systems use cell-
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associated and soluble receptors to recognize microbes, display some degree of self-
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nonself discrimination, and protect against viruses. On repeated exposure to the same micr
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obe, the adaptive immune response becomes more rapid and of greater magnitude; this is t
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he manifestation of memory.
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4. Antibodies and T lymphocytes are the respective mediators of which two types of
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immunity?
a. Innate and adaptive kj kj


b. Passive and active kj kj


c. Specific and nonspecific kj kj


d. Humoral and cell-mediated kj kj


e. Adult and neonatal kj kj




ANS: D k j


Both B and T lymphocytes are pri ipal components of adaptive immunity. B lymphocytes pr
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oduce antibodies, which are the recognition and effector molecules of humoral immune resp
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onses to extracellular pathogens. T cells recognize and promote eradication of intracellular p
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athogens in cell- kj kj


mediated immunity. Passive and active immunity both can be mediated by either B or T lym
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phocytes. Specific immunity is another term for adaptive immunity. Both B and T lymphocy
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tes participate in adult adaptive immunity but are still developing in the neonatal period.
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5. The two major fu tional classes of effector T lymphocytes are:
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a. Helper T lymphocytes and cytotoxic T lymphocytes kj kj kj kj kj kj


b. Natural killer cells and cytoWtoWxW
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cyStes kj kj kj kj


c. Memory T cells and effector T cells kj kj kj kj kj kj


d. Helper cells and antigen-presenting cells kj kj kj kj


e. Cytotoxic T lymphocytes and target cells kj kj kj kj kj




ANS: A k j


T cells can be classified into effector subsets that perform different effector fu tions. Most ef
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fector T cells are either helper T lymphocytes, which enha e the responses of other immun
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e cells, i luding phagocytes and B cells, to infections, or cytotoxic T lymphocytes, which di
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rectly kill infected cells. Natural killer cells are not T lymphocytes.
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Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. kj kj kj kj kj kj kj kj kj kj kj kj kj kj




6. Which of the following cell types is required for all adaptive humoral immune responses?
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a. Natural killer cells kj kj


b. Dendritic cells kj


c. Cytolytic T lymphocytes kj kj


d. B lymphocytes kj


e. Helper T lymphocytes kj kj




ANS: D k j


Humoral immune responses are antibody- kj kj kj kj


mediated immune responses, and all antibodies are made by B lymphocytes and no other
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cell type. kj