PATHOPHYSIOLOGY THE BIOLOGIC BASIS FOR DISEASE IN ADULTS AND CHILDREN 8th Edition Kathryn L. McCance, Sue E. Huether (978-0275972486)

Pathophysiology The Biologic Basis for Disease in Adults and Children 8th Edition 97803235834
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Chapter 1 - Cellular Biology ________________________________________ 3
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Chapter 2 - Altered Cellular and Tissue Biology Environmental Agents _ 16
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Chapter 3 - The Cellular Environment Fluids and Electrolytes Acids and
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Bases __________________________________________________________ 28
Chapter 4 - Genes and Genetic Diseases ______________________________ 41
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Chapter 5 - Genes Environment-Lifestyle and Common Diseases ___________ 51
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Chapter 6 - Epigenetics and Disease __________________________________ 59
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Chapter 7 - Innate Immunity Inflammation ______________________________ 64
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Chapter 8 - Adaptive Immunity _______________________________________ 78
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Chapter 9 - Alterations in Immunity and Inflammation ____________________ 89
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Chapter 10 - Infection _____________________________________________ 102
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Chapter 11 - Stress and Disease ____________________________________ 110
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Chapter 12 - Cancer Biology _______________________________________ 117
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Chapter 13 - Cancer Epidemiology __________________________________ 129
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Chapter 14 - Cancer in Children _____________________________________ 135
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Chapter 15 - Structure and Function of the Neurologic System _____________ 140
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Chapter 16 - h g h g




h g Pain Temperature Regulation Sleep and Sensory Function 151 Chapter 17 -
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hg Alterations in Cognitive Systems Cerebral Hemodynamics and
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Motor Function __________________________________________________ 165
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Chapter 18 - Disorders of the Central and Peripheral Nervous Systems and
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the Neuromuscular Junction ________________________________________ 179
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Chapter 19 - hg hg




hg Neurobiology of Schizophrenia Mood Disorders and Anxiety Disorders _____ 189
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Chapter 20 - Alterations of Neurologic Function in Children _______________ 195
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Chapter 21 - Mechanisms of Hormonal Regulation ______________________ 202
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Chapter 22 - Alterations of Hormonal Regulation________________________ 211
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Chapter 23 - Obesity and Disorders of Nutrition NEW ____________________ 223
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Chapter 24 - Structure and Function of the Reproductive Systems __________ 228
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Chapter 25 - Alterations of the Female Reproductive System ______________ 237
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,Pathophysiology The Biologic Basis for Disease in Adults and Children 8th Edition 97803235834
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Chapter 26 - Alterations of the Male Reproductive System ________________ 246
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Chapter 27 - Sexually Transmitted Infections___________________________ 252
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Chapter 28 - Structure and Function of the Hematologic System ___________ 260
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Chapter 29 - Alterations of Erythrocyte Platelet and Hemostatic Function ____ 270
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Chapter 30 - Alterations of Leukocyte and Lymphoid Function _____________ 280
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Chapter 31 - Alterations of Hematologic Function in Children ______________ 287
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Chapter 32 - hg hg




hg Structure and Function of the Cardiovascular and Lymphatic Systems ______ 297
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Chapter 33 - Alterations of Cardiovascular Function _____________________ 309
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Chapter 34 - Alterations of Cardiovascular Function in Children ____________ 323
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Chapter 35 - Structure and Function of the Pulmonary System _____________ 331
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Chapter 36 - Alterations of Pulmonary Function ________________________ 341
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Chapter 37 - Alterations of Pulmonary Function in Children _______________ 357
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Chapter 38 - Structure and Function of the Renal and Urologic Systems _____ 365
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Chapter 39 - Alterations of Renal and Urinary Function___________________ 375
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Chapter 40 - Alterations of Renal and Urinary Tract Function in Children _____ 385
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Chapter 41 - Structure and Function of the Digestive System ______________ 393
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Chapter 42 - Alterations of Digestive Function __________________________ 404
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Chapter 43 - Alterations of Digestive Function in Children _________________ 415
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Chapter 44 - Structure and Function of the Musculoskeletal System ________ 424
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Chapter 45 - Alterations of Musculoskeletal Function ____________________ 436
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Chapter 46 - Alterations of Musculoskeletal Function in Children ___________ 448
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Chapter 47 - Structure Function and Disorders of the Integument __________ 457
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Chapter 48 - Alterations of the Integument in Children ___________________ 468
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Chapter 49 - Shock Multiple Organ Dysfunction Syndrome and Burns in
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Adults 476
Chapter 50 - Shock Multiple Organ Dysfunction Syndrome and Burns in
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Children ________________________________________________________ 483

,Pathophysiology The Biologic Basis for Disease in Adults and Children 8th Edition 97803235834
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Chapter 01: Cellular Biology
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McCance/Huether: Pathophysiology: The Biologic Basis of Disease in Adults and Chil hg hg hg hg hg hg hg hg hg hg




dren, 8th Edition
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MULTIPLE CHOICE hg




1. Which statement best describes the cellular function of metabolic absorption?
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a. Cells can produce proteins. hg hg hg



b. Cells can secrete digestive enzymes. hg hg hg hg



c. Cells can take in and use nutrients. hg hg hg hg hg hg



d. Cells can synthesize fats. hg hg hg




ANS: C hg



In metabolic absorption, all cells take in and use nutrients and other substances from their su
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rroundings. The remaining options are not inclusive in their descriptions of cellular metabo
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lic absorption.
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PTS: h g h g 1 DIF: Cognitive Level: Remembering hg hg




2. Where is most of a cell’s genetic information, including RNA and DNA, contained?
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a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome

ANS: C hg



The nucleus contains the nucleolus, a small dense structure composed largely of RNA, most o
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f the cellular DNA, and the DNA-
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binding proteins, such as the histones, which regulate its activity. The mitochondria are respo
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nsible for cellular respiration and energy production.
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Ribosomes’ chief function is to provide sites for cellular protein synthesis. Lysosomes funct
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ion as the intracellular digestive system.
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PTS: h g h g 1 DIF: Cognitive Level: Remembering hg hg




3. Which component of the cell produces hydrogen peroxide (H2O2) by using oxygen to remove
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hydrogen atoms from specific substrates in an oxidative reaction?
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a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome

ANS: B hg




Chapter 1 - Cellular Biology
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, Pathophysiology The Biologic Basis for Disease in Adults and Children 8th Edition 97803235834
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Peroxisomes are so named because they usually contain enzymes that use oxygen to remove h
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ydrogen atoms from specific substrates in an oxidative reaction that produces H2O2, which is a
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powerful oxidant and potentially destructive if it accumulates or escapes from peroxisomes.
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Ribosomes are RNA- hg hg



protein complexes (nucleoproteins) that are synthesized in the nucleolus and secreted into the
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cytoplasm through pores in the nuclear envelope called nuclear pore complexes. Lysosomes a
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re saclike structures that originate from the Golgi complex and contain more than 40 digestive
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enzymes called hydrolases, which catalyze bonds in proteins, lipids, nucleic acids, and carbo
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hydrates. An endosome is a vesical that has been pinched off from the cellular membrane.
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PTS: h g h g 1 DIF: Cognitive Level: Remembering hg hg




4. Which cell component is capable of cellular autodigestion when it is released during cell
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injury?
a. Ribosome
b. Golgi complex hg



c. Smooth endoplasmic reticulum hg hg



d. Lysosomes

ANS: D hg



The lysosomal membrane acts as a protective shield between the powerful digestive enzymes withi
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n the lysosome and the cytoplasm, preventing their leakage into the cytoplasmic matrix. Disruptio
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n of the membrane by various treatments or cellular injury leads to a release of the lysosomal enz
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ymes, which can then react with their specific substrates, causing cellular
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self-
digestion. The chief function of a ribosome is to provide sites for cellular protein synthesis. T
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he Golgi complex is a network of flattened, smooth vesicles and membranes often located near
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the cell nucleus. The smooth endoplasmic reticulum is involved in steroid hormone productio
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n and removing toxic substances from the cell.
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PTS: h g h g 1 DIF: Cognitive Level: Remembering hg hg




5. Which cAMP-mediated response is related to antidiuretic hormone?
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a. Increased heart rate and force of contraction hg hg hg hg hg hg



b. Secretion of cortisol hg hg



c. Increased retention of water hg hg hg



d. Breakdown of fat hg hg




ANS: C hg



Antidiuretic hormone leads to increased retention of water in the body. Epinephrine causes increa
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ses in heart rate and force of contraction. Increased cortisol secretion is due to ACTH. Breakdown
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of fat is due to glucagon.
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PTS: h g h g 1 DIF: Cognitive Level: Remembering hg hg




6. During which phase of the cell cycle is DNA synthesized?
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a. G1
b. S
c. G2
d. M
ANS: B hg




Chapter 1 - Cellular Biology
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