ASCP HEMATOLOGY REVIEW
QUESTIONS & ANSWERS(RATED
A+)
Yolk Sac (0-1.5 Months)
Liver, Spleen (0.5 and 1.8 Months)
Bone Marrow, Lymph Nodes (4 and 4.5 Months) - ANSWEROrder of Prenatal
Hematopoiesis during gestation
Later Precursors (UR, COP, PROTO) - ANSWERCutaneous symptoms such as
photosensitivity, facial hair
Hemosiderosis and Hemochromatosis (Organ Damage) - ANSWERConditions
associated with Increased Storage of Iron
*While in DELTA, POuR yoUR COP, PRONTO, a cup of HEME -
ANSWERPrecursors of Heme, IN ORDER
Gower 1 - ANSWERHgb with Globin Chain zeta2epsilon2 (0% in newborn and adult)
Flat Bones (colony forming units in red marrow):
Skull
Sternum
Pelvis
Ribs
Vertebrae - ANSWERActive adult hemopoietic tissue
Transferrin - ANSWERFe transport protein
Ferritin - ANSWERMajor Fe storage form
Hemosiderin - ANSWERH2O insoluble Fe storage form (long-term)
Porphyrias - ANSWEREnzyme deficiencies cause build-up of heme precursors
Early Precursors (DELTA ala or PORphobilinogen) - ANSWERNeuropsychiatric
symptoms, i.e. acute intermittent porphyria or AIP
Gower 2 - ANSWERHgb with Globin Chain alpha2epsilon2 (0% in newborn and
adult)
Portland - ANSWERHgb with Globin Chain zeta2gamma2 (0% in newborn and adult)
, HgbF - ANSWERHgb with Globin Chain alpha2gamma2 (60-90% newborn, 0%
adult)
Hgb A2 - ANSWERHgb with Globin Chain alpha2delta2 (<2% in newborn and 2%
adult)
HgbA - ANSWERHgb with Globin Chain alpha2beta2 (10-40% newborn and 97%
adult)
Left Shift
*Right - Won't Hold Tight
Left - No! Won't Let GO - ANSWERHemoglobin-Oxygen dissociation when O2 is
NOT released to tissue adequately
Decreased CO2
Increased pH
HgbF (High affinity)
Multiple Transfusions (Decreased 2,3-DPG) - ANSWERWhat is increased/decreased
due to a left shift?
Inflammation - ANSWERWhat is the most common cause of a left shift?
EDTA - ANSWERChelates Ca2+
Heparin - ANSWERAnti-Thrombin Agent
KCN and KFerricyanide or Sodium Laurel Sulfate - ANSWERPrinciple of hemoglobin
test is oxidation of hemoglobin to methemoglobin using...
Lipemia/Icterus
High WBC Count
Resisting hemoglobins (SS, CC) - ANSWERSources of error when measuring
hemoglobin
Methemoglobin - ANSWERFe++ Oxidized to Fe+++, Brown, Cannot Bind O2
Carboxyhemoglobin - ANSWERIncreased in Carbon Monoxide Poisoning and
Smokers, Cherry-Red
Sulfhemoglobin - ANSWEROnly hemoglobin not measured by cyanmethemoglobin
method
Hematocrit (Hct%) - ANSWERMeasures packed cell volume
MCV and RBC - ANSWERWhat is the automated method of measuring hematocrit
calculated from?
QUESTIONS & ANSWERS(RATED
A+)
Yolk Sac (0-1.5 Months)
Liver, Spleen (0.5 and 1.8 Months)
Bone Marrow, Lymph Nodes (4 and 4.5 Months) - ANSWEROrder of Prenatal
Hematopoiesis during gestation
Later Precursors (UR, COP, PROTO) - ANSWERCutaneous symptoms such as
photosensitivity, facial hair
Hemosiderosis and Hemochromatosis (Organ Damage) - ANSWERConditions
associated with Increased Storage of Iron
*While in DELTA, POuR yoUR COP, PRONTO, a cup of HEME -
ANSWERPrecursors of Heme, IN ORDER
Gower 1 - ANSWERHgb with Globin Chain zeta2epsilon2 (0% in newborn and adult)
Flat Bones (colony forming units in red marrow):
Skull
Sternum
Pelvis
Ribs
Vertebrae - ANSWERActive adult hemopoietic tissue
Transferrin - ANSWERFe transport protein
Ferritin - ANSWERMajor Fe storage form
Hemosiderin - ANSWERH2O insoluble Fe storage form (long-term)
Porphyrias - ANSWEREnzyme deficiencies cause build-up of heme precursors
Early Precursors (DELTA ala or PORphobilinogen) - ANSWERNeuropsychiatric
symptoms, i.e. acute intermittent porphyria or AIP
Gower 2 - ANSWERHgb with Globin Chain alpha2epsilon2 (0% in newborn and
adult)
Portland - ANSWERHgb with Globin Chain zeta2gamma2 (0% in newborn and adult)
, HgbF - ANSWERHgb with Globin Chain alpha2gamma2 (60-90% newborn, 0%
adult)
Hgb A2 - ANSWERHgb with Globin Chain alpha2delta2 (<2% in newborn and 2%
adult)
HgbA - ANSWERHgb with Globin Chain alpha2beta2 (10-40% newborn and 97%
adult)
Left Shift
*Right - Won't Hold Tight
Left - No! Won't Let GO - ANSWERHemoglobin-Oxygen dissociation when O2 is
NOT released to tissue adequately
Decreased CO2
Increased pH
HgbF (High affinity)
Multiple Transfusions (Decreased 2,3-DPG) - ANSWERWhat is increased/decreased
due to a left shift?
Inflammation - ANSWERWhat is the most common cause of a left shift?
EDTA - ANSWERChelates Ca2+
Heparin - ANSWERAnti-Thrombin Agent
KCN and KFerricyanide or Sodium Laurel Sulfate - ANSWERPrinciple of hemoglobin
test is oxidation of hemoglobin to methemoglobin using...
Lipemia/Icterus
High WBC Count
Resisting hemoglobins (SS, CC) - ANSWERSources of error when measuring
hemoglobin
Methemoglobin - ANSWERFe++ Oxidized to Fe+++, Brown, Cannot Bind O2
Carboxyhemoglobin - ANSWERIncreased in Carbon Monoxide Poisoning and
Smokers, Cherry-Red
Sulfhemoglobin - ANSWEROnly hemoglobin not measured by cyanmethemoglobin
method
Hematocrit (Hct%) - ANSWERMeasures packed cell volume
MCV and RBC - ANSWERWhat is the automated method of measuring hematocrit
calculated from?
