COMPLETE TEST BANK FOR LEHNE’S
PHARMACOTHERAPEUTICS FOR ADVANCED PRACTICE
NURSES AND PHYSICIAN ASSISTANTS 3RD EDITION BY
JACQUELINE ROSENJACK BURCHUM, LAURA D.
ROSENTHAL
, TABLE OF CONTENTS
UNIT I INTRODUCTION............................................................................................... 6
CHAPTER 1: PRESCRIPTIVE AUTHORITY .................................................................................... 6
CHAPTER 2: RATIONAL DRUG SELECTION AND PRESCRIPTION WRITING ......................... 10
CHAPTER 3: PROMOTING POSITIVE OUTCOMES OF DRUG THERAPY ................................. 17
UNIT II BASIC PRINCIPLES OF PHARMACOLOGY ........................................................ 23
CHAPTER 4: PHARMACOKINETICS, PHARMACODYNAMICS, AND DRUG INTERACTIONS 23
CHAPTER 5: ADVERSE DRUG REACTIONS AND MEDICATION ERRORS .............................. 34
CHAPTER 6: INDIVIDUAL VARIATION IN DRUG RESPONSES ................................................. 45
CHAPTER 7 GENETIC AND GENOMIC CONSIDERATIONS IN PHARMACOTHERAPEUTICS 54
UNIT III DRUG THERAPY ACROSS THE LIFE SPAN ....................................................... 64
CHAPTER 8: DRUG THERAPY DURING PREGNANCY AND BREAST-FEEDING ..................... 64
CHAPTER 9: DRUG THERAPY IN PEDIATRIC PATIENTS.......................................................... 72
CHAPTER 10: DRUG THERAPY IN GERIATRIC.......................................................................... 82
UNIT IV PERIPHERAL NERVOUS SYSTEM DRUGS ........................................................ 92
CHAPTER 11: BASIC PRINCIPLES OF NEUROPHARMACOLOGY ........................................... 92
CHAPTER 12: PHYSIOLOGY OF THE PERIPHERAL NERVOUS SYSTEM ................................ 98
CHAPTER 13: MUSCARINIC AGONISTS ...................................................................................106
CHAPTER 14 MUSCARINIC ANTAGONISTS ............................................................................113
CHAPTER 15: ADRENERGIC AGONISTS ..................................................................................120
CHAPTER 16: ADRENERGIC ANTAGONISTS ...........................................................................130
CHAPTER 17: INDIRECT-ACTING ANTIADRENERGIC AGENTS .............................................142
UNIT V CENTRAL NERVOUS SYSTEM DRUGS ............................................................. 152
CHAPTER 18: INTRODUCTION TO CENTRAL NERVOUS SYSTEM PHARMACOLOGY ........152
CHAPTER 19: DRUGS FOR PARKINSON'S DISEASE .............................................................159
CHAPTER 20: DRUGS FOR ALZHEIMER'S DISEASE ..............................................................167
CHAPTER 21: DRUGS FOR SEIZURE DISORDERS .................................................................175
CHAPTER 22: DRUGS FOR MUSCLE SPASM AND SPASTICITY ...........................................183
UNIT VI DRUGS FOR PAIN ...................................................................................... 191
CHAPTER 23: LOCAL ANESTHETICS ........................................................................................191
, CHAPTER 24: OPIOID ANALGESICS, OPIOID ANTAGONISTS, AND NONOPIOID CENTRALLY
ACTING ANALGESICS .................................................................................................................201
CHAPTER 25: DRUGS FOR HEADACHE ...................................................................................212
UNIT VII PSYCHOTHERAPEUTIC DRUGS................................................................... 223
CHAPTER 26: ANTIPSYCHOTIC AGENTS AND THEIR USE IN SCHIZOPHRENIA ................223
CHAPTER 27: ANTIDEPRESSANTS ..........................................................................................235
CHAPTER 28: DRUGS FOR BIPOLAR DISORDER...................................................................244
CHAPTER 29: SEDATIVE-HYPNOTIC DRUGS...........................................................................254
CHAPTER 30: MANAGEMENT OF ANXIETY DISORDERS ......................................................260
CHAPTER 31: CENTRAL NERVOUS SYSTEM STIMULANTS AND ATTENTION-
DEFICIT/HYPERACTIVITY DISORDER ......................................................................................269
UNIT VIII SUBSTANCE USE DISORDERS ................................................................... 278
CHAPTER 32: DRUG ABUSE I: BASIC CONSIDERATIONS .....................................................278
CHAPTER 33: DRUG ABUSE II: ALCOHOL ...............................................................................285
CHAPTER 34: DRUG ABUSE III: NICOTINE AND SMOKING ...................................................294
CHAPTER 35: DRUG ABUSE IV: MAJOR DRUGS OF ABUSE OTHER THAN ALCOHOL AND
NICOTINE .....................................................................................................................................303
UNIT IX DRUGS THAT AFFECT THE HEART, BLOOD VESSELS, BLOOD, AND BLOOD VOLUME
........................................................................................................................... 318
CHAPTER 36: REVIEW OF HEMODYNAMICS ..........................................................................318
CHAPTER 37: DIURETICS ..........................................................................................................323
CHAPTER 38: DRUGS ACTING ON THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM ..330
CHAPTER 39: CALCIUM CHANNEL BLOCKERS ......................................................................340
CHAPTER 40: VASODILATORS .................................................................................................345
CHAPTER 41: DRUGS FOR HYPERTENSION ...........................................................................353
CHAPTER 42: DRUGS FOR HEART FAILURE...........................................................................369
CHAPTER 43: ANTIDYSRHYTHMIC DRUGS.............................................................................385
CHAPTER 44: PROPHYLAXIS OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE:
DRUGS THAT HELP NORMALIZE CHOLESTEROL AND TRIGLYCERIDE LEVELS ................402
CHAPTER 45: DRUGS FOR ANGINA PECTORIS......................................................................416
CHAPTER 46: ANTICOAGULANT, ANTIPLATELET, AND THROMBOLYTIC DRUGS .............429
CHAPTER 47: DRUGS FOR DEFICIENCY ANEMIAS ................................................................444
, UNIT X DRUGS FOR ENDOCRINE DISORDERS .......................................................... 455
CHAPTER 48: DRUGS FOR DIABETES MELLITUS ..................................................................455
CHAPTER 49: DRUGS FOR THYROID DISORDERS ................................................................467
UNIT XI REPRODUCTIVE HEALTH ............................................................................ 478
CHAPTER 50: ESTROGENS AND PROGESTINS: BASIC PHARMACOLOGY AND
NONCONTRACEPTIVE APPLICATIONS .....................................................................................478
CHAPTER 51: BIRTH CONTROL ................................................................................................485
CHAPTER 52: ANDROGENS ......................................................................................................497
CHAPTER 53: DRUGS FOR ERECTILE DYSFUNCTION AND BENIGN PROSTATIC
HYPERPLASIA .............................................................................................................................506
CHAPTER 54: REVIEW OF THE IMMUNE SYSTEM .................................................................511
CHAPTER 55: CHILDHOOD IMMUNIZATION ...........................................................................519
UNIT XII ANTIINFLAMMATORY, ANTIALLERGIC, AND IMMUNOLOGIC DRUGS................. 530
CHAPTER 56: ANTIHISTAMINES...............................................................................................530
CHAPTER 57: CYCLOOXYGENASE INHIBITORS: NONSTEROIDAL ANTI-INFLAMMATORY
DRUGS AND ACETAMINOPHEN ................................................................................................540
CHAPTER 58: GLUCOCORTICOIDS IN NONENDOCRINE DISORDERS .................................551
CHAPTER 59: DRUG THERAPY OF RHEUMATOID ARTHRITIS .............................................563
CHAPTER 60: DRUG THERAPY OF GOUT ................................................................................569
UNIT XIII DRUGS FOR BONE AND JOINT DISORDERS ................................................ 577
CHAPTER 61: DRUGS AFFECTING CALCIUM LEVELS AND BONE MINERALIZATION........577
CHAPTER 62: DRUGS FOR ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
......................................................................................................................................................589
CHAPTER 63: DRUGS FOR ALLERGIC RHINITIS, COUGH, AND COLDS ..............................603
UNIT XIV RESPIRATORY TRACT DRUGS ................................................................... 615
CHAPTER 64: DRUGS FOR PEPTIC ULCER DISEASE.............................................................615
CHAPTER 65: LAXATIVES ..........................................................................................................624
UNIT XV GASTROINTESTINAL DRUGS ...................................................................... 635
CHAPTER 66: OTHER GASTROINTESTINAL DRUGS ..............................................................635
CHAPTER 67: VITAMINS ............................................................................................................650
CHAPTER 68: DRUGS FOR WEIGHT LOSS ..............................................................................659
UNIT XVI NUTRITION AND COMPLEMENTARY THERAPIES .......................................... 669
PHARMACOTHERAPEUTICS FOR ADVANCED PRACTICE
NURSES AND PHYSICIAN ASSISTANTS 3RD EDITION BY
JACQUELINE ROSENJACK BURCHUM, LAURA D.
ROSENTHAL
, TABLE OF CONTENTS
UNIT I INTRODUCTION............................................................................................... 6
CHAPTER 1: PRESCRIPTIVE AUTHORITY .................................................................................... 6
CHAPTER 2: RATIONAL DRUG SELECTION AND PRESCRIPTION WRITING ......................... 10
CHAPTER 3: PROMOTING POSITIVE OUTCOMES OF DRUG THERAPY ................................. 17
UNIT II BASIC PRINCIPLES OF PHARMACOLOGY ........................................................ 23
CHAPTER 4: PHARMACOKINETICS, PHARMACODYNAMICS, AND DRUG INTERACTIONS 23
CHAPTER 5: ADVERSE DRUG REACTIONS AND MEDICATION ERRORS .............................. 34
CHAPTER 6: INDIVIDUAL VARIATION IN DRUG RESPONSES ................................................. 45
CHAPTER 7 GENETIC AND GENOMIC CONSIDERATIONS IN PHARMACOTHERAPEUTICS 54
UNIT III DRUG THERAPY ACROSS THE LIFE SPAN ....................................................... 64
CHAPTER 8: DRUG THERAPY DURING PREGNANCY AND BREAST-FEEDING ..................... 64
CHAPTER 9: DRUG THERAPY IN PEDIATRIC PATIENTS.......................................................... 72
CHAPTER 10: DRUG THERAPY IN GERIATRIC.......................................................................... 82
UNIT IV PERIPHERAL NERVOUS SYSTEM DRUGS ........................................................ 92
CHAPTER 11: BASIC PRINCIPLES OF NEUROPHARMACOLOGY ........................................... 92
CHAPTER 12: PHYSIOLOGY OF THE PERIPHERAL NERVOUS SYSTEM ................................ 98
CHAPTER 13: MUSCARINIC AGONISTS ...................................................................................106
CHAPTER 14 MUSCARINIC ANTAGONISTS ............................................................................113
CHAPTER 15: ADRENERGIC AGONISTS ..................................................................................120
CHAPTER 16: ADRENERGIC ANTAGONISTS ...........................................................................130
CHAPTER 17: INDIRECT-ACTING ANTIADRENERGIC AGENTS .............................................142
UNIT V CENTRAL NERVOUS SYSTEM DRUGS ............................................................. 152
CHAPTER 18: INTRODUCTION TO CENTRAL NERVOUS SYSTEM PHARMACOLOGY ........152
CHAPTER 19: DRUGS FOR PARKINSON'S DISEASE .............................................................159
CHAPTER 20: DRUGS FOR ALZHEIMER'S DISEASE ..............................................................167
CHAPTER 21: DRUGS FOR SEIZURE DISORDERS .................................................................175
CHAPTER 22: DRUGS FOR MUSCLE SPASM AND SPASTICITY ...........................................183
UNIT VI DRUGS FOR PAIN ...................................................................................... 191
CHAPTER 23: LOCAL ANESTHETICS ........................................................................................191
, CHAPTER 24: OPIOID ANALGESICS, OPIOID ANTAGONISTS, AND NONOPIOID CENTRALLY
ACTING ANALGESICS .................................................................................................................201
CHAPTER 25: DRUGS FOR HEADACHE ...................................................................................212
UNIT VII PSYCHOTHERAPEUTIC DRUGS................................................................... 223
CHAPTER 26: ANTIPSYCHOTIC AGENTS AND THEIR USE IN SCHIZOPHRENIA ................223
CHAPTER 27: ANTIDEPRESSANTS ..........................................................................................235
CHAPTER 28: DRUGS FOR BIPOLAR DISORDER...................................................................244
CHAPTER 29: SEDATIVE-HYPNOTIC DRUGS...........................................................................254
CHAPTER 30: MANAGEMENT OF ANXIETY DISORDERS ......................................................260
CHAPTER 31: CENTRAL NERVOUS SYSTEM STIMULANTS AND ATTENTION-
DEFICIT/HYPERACTIVITY DISORDER ......................................................................................269
UNIT VIII SUBSTANCE USE DISORDERS ................................................................... 278
CHAPTER 32: DRUG ABUSE I: BASIC CONSIDERATIONS .....................................................278
CHAPTER 33: DRUG ABUSE II: ALCOHOL ...............................................................................285
CHAPTER 34: DRUG ABUSE III: NICOTINE AND SMOKING ...................................................294
CHAPTER 35: DRUG ABUSE IV: MAJOR DRUGS OF ABUSE OTHER THAN ALCOHOL AND
NICOTINE .....................................................................................................................................303
UNIT IX DRUGS THAT AFFECT THE HEART, BLOOD VESSELS, BLOOD, AND BLOOD VOLUME
........................................................................................................................... 318
CHAPTER 36: REVIEW OF HEMODYNAMICS ..........................................................................318
CHAPTER 37: DIURETICS ..........................................................................................................323
CHAPTER 38: DRUGS ACTING ON THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM ..330
CHAPTER 39: CALCIUM CHANNEL BLOCKERS ......................................................................340
CHAPTER 40: VASODILATORS .................................................................................................345
CHAPTER 41: DRUGS FOR HYPERTENSION ...........................................................................353
CHAPTER 42: DRUGS FOR HEART FAILURE...........................................................................369
CHAPTER 43: ANTIDYSRHYTHMIC DRUGS.............................................................................385
CHAPTER 44: PROPHYLAXIS OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE:
DRUGS THAT HELP NORMALIZE CHOLESTEROL AND TRIGLYCERIDE LEVELS ................402
CHAPTER 45: DRUGS FOR ANGINA PECTORIS......................................................................416
CHAPTER 46: ANTICOAGULANT, ANTIPLATELET, AND THROMBOLYTIC DRUGS .............429
CHAPTER 47: DRUGS FOR DEFICIENCY ANEMIAS ................................................................444
, UNIT X DRUGS FOR ENDOCRINE DISORDERS .......................................................... 455
CHAPTER 48: DRUGS FOR DIABETES MELLITUS ..................................................................455
CHAPTER 49: DRUGS FOR THYROID DISORDERS ................................................................467
UNIT XI REPRODUCTIVE HEALTH ............................................................................ 478
CHAPTER 50: ESTROGENS AND PROGESTINS: BASIC PHARMACOLOGY AND
NONCONTRACEPTIVE APPLICATIONS .....................................................................................478
CHAPTER 51: BIRTH CONTROL ................................................................................................485
CHAPTER 52: ANDROGENS ......................................................................................................497
CHAPTER 53: DRUGS FOR ERECTILE DYSFUNCTION AND BENIGN PROSTATIC
HYPERPLASIA .............................................................................................................................506
CHAPTER 54: REVIEW OF THE IMMUNE SYSTEM .................................................................511
CHAPTER 55: CHILDHOOD IMMUNIZATION ...........................................................................519
UNIT XII ANTIINFLAMMATORY, ANTIALLERGIC, AND IMMUNOLOGIC DRUGS................. 530
CHAPTER 56: ANTIHISTAMINES...............................................................................................530
CHAPTER 57: CYCLOOXYGENASE INHIBITORS: NONSTEROIDAL ANTI-INFLAMMATORY
DRUGS AND ACETAMINOPHEN ................................................................................................540
CHAPTER 58: GLUCOCORTICOIDS IN NONENDOCRINE DISORDERS .................................551
CHAPTER 59: DRUG THERAPY OF RHEUMATOID ARTHRITIS .............................................563
CHAPTER 60: DRUG THERAPY OF GOUT ................................................................................569
UNIT XIII DRUGS FOR BONE AND JOINT DISORDERS ................................................ 577
CHAPTER 61: DRUGS AFFECTING CALCIUM LEVELS AND BONE MINERALIZATION........577
CHAPTER 62: DRUGS FOR ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
......................................................................................................................................................589
CHAPTER 63: DRUGS FOR ALLERGIC RHINITIS, COUGH, AND COLDS ..............................603
UNIT XIV RESPIRATORY TRACT DRUGS ................................................................... 615
CHAPTER 64: DRUGS FOR PEPTIC ULCER DISEASE.............................................................615
CHAPTER 65: LAXATIVES ..........................................................................................................624
UNIT XV GASTROINTESTINAL DRUGS ...................................................................... 635
CHAPTER 66: OTHER GASTROINTESTINAL DRUGS ..............................................................635
CHAPTER 67: VITAMINS ............................................................................................................650
CHAPTER 68: DRUGS FOR WEIGHT LOSS ..............................................................................659
UNIT XVI NUTRITION AND COMPLEMENTARY THERAPIES .......................................... 669
