NR 546 Week 3 questions with 100% correct detailed answers (verified answers) already passed and rated a+

NR 546 Week 3 questions with
ss ss ss ss ss




100% correct detailed answers
ss ss ss ss




(verified answers) already passed
ss ss ss ss




and rated a+ ss ss ss




Antipsychotics Table Assignments
ss ss .

, Drug ssname Indication Half-life Notable ssside sseffects ss(associate ssto sspathway ssor
Target sssymptoms: ssstate ssif sspositive ssor ssnegative ss(T1/2), ssNT)

sseffectsPotency ss(if ssnoted. ssreceptor ssoccupancy ssif smetabolism

ssnoted ss) ssNeurotransmitter(s) ssaffected ss(CYP ss450

enzyme)

Typical ssantipsychotics ss(conventional)
Haloperidol Blocks ssdopamine ss2 ssreceptors, ssreducing sspositive Decanoate Acute ssblockade ssof ssdopamine ss2 ssreceptors
sssymptoms ssof sspsychosis ssand sspossibly sscombative, sshalf-life ssin ssthe s s triatum sscan sscause ssdrug-induced

ssexplosive, ssand sshyperactive ssbehaviors ssBlocks ssapproximatel ssparkinsonism,sdystonia, ssor ssakathisia

ssdopamines2 ssreceptors ssin ssthe ssnigrostriatal sspathway, ys3 ssweeks Chronic ssblockade ssof ssdopamine ss2 ssreceptors ssin
ssimproving ssticssand ssother sssymptoms ssin ssTourette’s ssOral sshalf-life ssthesstriatum sscan sscause sstardive ssdyskinesia

sssyndrome. ssapproximatel By ssblocking ssdopamine ss2 ssreceptors ssin ssthe
ys12–38 sshours sspituitary,sit sscan sscause sselevations ssin ssprolactin

By ssblocking ssdopamine ss2 ssreceptors
ssexcessively ssinsthe ssmesocortical ssand

ssmesolimbic ssdopamine sspathways, ssespecially

ssat sshigh ssdoses, ssit sscan sscause ssworsening ssof

ssnegative ssand sscognitive sssymptoms

ss(neuroleptic-induced ssdeficit sssyndrome).

Blocking ssalpha ss1 ssadrenergic ssreceptors sscan sscause
dizziness, sshypotension, ssand sssyncope
Thioridazine Blocks ssdopamine ss2 ssreceptors, ssreducing Metabolized Acute ssblockade ssof ssdopamine ss2 ssreceptors
sspositives
s ymptoms ssof sspsychosis ssby ssCYP450 ssin ssthe sstriatum sscan sscause ssdrug-induced

ss2D6 ssparkinsonism,sdystonia, ssor ssakathisia.

Chronic ssblockade ssof ssdopamine ss2 ssreceptors ssin
ssthesstriatum sscan sscause sstardive ssdyskinesia

By ssblocking ssdopamine ss2 ssreceptors ssin ssthe
sspituitary,sit sscan sscause sselevations ssin ssprolactin

By ssblocking ssdopamine ss2 ssreceptors
ssexcessively ssinsthe ssmesocortical ssand

ssmesolimbic ssdopamine sspathways, ssespecially

ssat sshigh ssdoses, ssit sscan sscause ssworsening ssof

ssnegative ssand sscognitive sssymptoms

ss(neuroleptic-induced ssdeficit sssyndrome)

Blocking ssmuscarinic sscholinergic ssreceptors sscan