RBC Exam UPDATED Exam Questions
and CORRECT Answers
three areas of RBC metabolism that are crucial for normal erythrocyte survival and function: -
CORRECT ANSWER -- RBC membrane
- hemoglobin structure and function
- RBC metabolic pathways
3 layers of RBC membrane - CORRECT ANSWER -- outer hydrophilic= glycolipid,
glycoprotein, and protein
- central hydrophobic= protein, cholesterol, and phospholipid
- inner hydrophilic= contains proteins
**40% lipids, 52% proteins, and 8% carbs
2 important proteins within the cell membrane - CORRECT ANSWER -- sceptrin
- glycophorin
spectrin - CORRECT ANSWER -- A fibrous protein that gives shape to an RBC plasma
membrane.
- helps maintain biconcave shape and flexibility of RBC
- alpha and beta chain
glycophorin - CORRECT ANSWER -integral membrane protein
- accounts for most of the sialic acid, which gives RBC neg charge
RBC permeability - CORRECT ANSWER -- freely permeable to water and anions (Cl and
HCO3)
- the more cholesterol the less permeable
, target cells - CORRECT ANSWER -cholesterol accumulation in the RBC membrane
- thalassemia, liver disease, asplenia, HbC disease
acanthocytes (spur cells) - CORRECT ANSWER -- Abetalipoproteinemia with cholesterol
accumulation
- liver disease
hemolysis with RBC fragmentation - CORRECT ANSWER -- LCAT deficiency with
cholesterol accumulation
bite cells and spherocytes - CORRECT ANSWER -- Decreased phosphorylated spectrin or
altered spectrin
hemoglobin synthesis dependent on 3 processes - CORRECT ANSWER -- adequate iron
delivery
- adequate synthesis of protoporphyrin's
- adequate globin synthesis
iron delivery process - CORRECT ANSWER -- iron in ferric state (Fe3+), delivered to
RBC by transferrin
- iron crosses membrane and begins hemoglobin synthesis
- (ferric) Fe3+ is reduced to (ferrous) Fe2+ in the mitochondria
- excess iron in cytoplasm aggregates as ferritin
transferrin - CORRECT ANSWER -- a protein that transport iron to the membrane of the
immature cell
ferritin aggregates - CORRECT ANSWER -excess iron that accumulates in the cytoplasm
of immature cells
and CORRECT Answers
three areas of RBC metabolism that are crucial for normal erythrocyte survival and function: -
CORRECT ANSWER -- RBC membrane
- hemoglobin structure and function
- RBC metabolic pathways
3 layers of RBC membrane - CORRECT ANSWER -- outer hydrophilic= glycolipid,
glycoprotein, and protein
- central hydrophobic= protein, cholesterol, and phospholipid
- inner hydrophilic= contains proteins
**40% lipids, 52% proteins, and 8% carbs
2 important proteins within the cell membrane - CORRECT ANSWER -- sceptrin
- glycophorin
spectrin - CORRECT ANSWER -- A fibrous protein that gives shape to an RBC plasma
membrane.
- helps maintain biconcave shape and flexibility of RBC
- alpha and beta chain
glycophorin - CORRECT ANSWER -integral membrane protein
- accounts for most of the sialic acid, which gives RBC neg charge
RBC permeability - CORRECT ANSWER -- freely permeable to water and anions (Cl and
HCO3)
- the more cholesterol the less permeable
, target cells - CORRECT ANSWER -cholesterol accumulation in the RBC membrane
- thalassemia, liver disease, asplenia, HbC disease
acanthocytes (spur cells) - CORRECT ANSWER -- Abetalipoproteinemia with cholesterol
accumulation
- liver disease
hemolysis with RBC fragmentation - CORRECT ANSWER -- LCAT deficiency with
cholesterol accumulation
bite cells and spherocytes - CORRECT ANSWER -- Decreased phosphorylated spectrin or
altered spectrin
hemoglobin synthesis dependent on 3 processes - CORRECT ANSWER -- adequate iron
delivery
- adequate synthesis of protoporphyrin's
- adequate globin synthesis
iron delivery process - CORRECT ANSWER -- iron in ferric state (Fe3+), delivered to
RBC by transferrin
- iron crosses membrane and begins hemoglobin synthesis
- (ferric) Fe3+ is reduced to (ferrous) Fe2+ in the mitochondria
- excess iron in cytoplasm aggregates as ferritin
transferrin - CORRECT ANSWER -- a protein that transport iron to the membrane of the
immature cell
ferritin aggregates - CORRECT ANSWER -excess iron that accumulates in the cytoplasm
of immature cells
