Exam (ch 1-12) *Q&A* (100% Correct)
2025/2026 |VERIFIED|
1. How does the body compensate for metabolic acidosis in critically ill patients?
The body compensates for metabolic acidosis primarily through respiratory compensation,
where increased ventilation helps to blow off carbon dioxide, thus reducing the concentration of
hydrogen ions.
2. What is the main goal of mechanical ventilation in patients with ARDS (acute respiratory distress
syndrome)?
The primary goal of mechanical ventilation in ARDS is to maintain adequate oxygenation while
minimizing ventilator-associated lung injury by using low tidal volumes and positive end-expiratory
pressure (PEEP).
3. How does sepsis lead to multi-organ dysfunction syndrome (MODS)?
Sepsis triggers a systemic inflammatory response, releasing cytokines and other mediators that
disrupt endothelial function, leading to vascular leakage, hypoperfusion, and tissue injury, ultimately
resulting in MODS.
4. What are the hallmark signs of hypovolemic shock?
Hallmark signs of hypovolemic shock include hypotension, tachycardia, reduced urine output,
cold and clammy skin, and altered mental status due to insufficient circulating volume.
5. Explain the concept of oxygen delivery (DO2) and its relation to critical care.
Oxygen delivery (DO2) is the amount of oxygen transported to tissues per minute. It depends
on cardiac output and the oxygen content of the blood. In critical care, maintaining adequate DO2 is
crucial for preventing tissue hypoxia.
6. How does the body respond to an increase in systemic vascular resistance (SVR) in the context of
shock?
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, An increase in SVR typically results in a compensatory increase in blood pressure and afterload
to maintain perfusion. However, prolonged high SVR can lead to decreased cardiac output and tissue
hypoxia.
7. What role does nitric oxide play in critically ill patients with sepsis?
Nitric oxide acts as a vasodilator and plays a significant role in sepsis by reducing systemic
vascular resistance, potentially contributing to hypotension and poor perfusion in critically ill patients.
8. What are the primary criteria for diagnosing acute kidney injury (AKI) in the ICU setting?
The primary criteria for diagnosing AKI include a rise in serum creatinine by ≥0.3 mg/dL within
48 hours or a reduction in urine output to <0.5 mL/kg/hr for more than 6 hours.
9. Describe the pathophysiology of diabetic ketoacidosis (DKA) in critically ill patients.
DKA is characterized by insulin deficiency, leading to increased lipolysis, ketone body
production, and metabolic acidosis. It is commonly triggered by infection, trauma, or non-compliance
with insulin therapy in critically ill patients.
10. What is the role of lactate measurement in critically ill patients?
Lactate is a marker of tissue hypoxia and inadequate perfusion. Elevated lactate levels indicate
anaerobic metabolism and are often used to guide resuscitation and monitor the severity of shock.
11. Explain the mechanism of action of vasopressors in the management of shock.
Vasopressors act by constricting blood vessels and increasing systemic vascular resistance,
which helps raise blood pressure and improve perfusion to vital organs during shock states.
12. In the context of fluid resuscitation in critical care, what is the role of crystalloids versus colloids?
Crystalloids, such as saline and lactated Ringer's, are often used as the first-line therapy for fluid
resuscitation due to their ability to expand the intravascular volume. Colloids are used in more severe
cases to restore plasma volume but are less frequently utilized due to cost and potential complications.
13. What is the primary cause of ventilator-associated pneumonia (VAP) in critically ill patients?
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, The primary cause of VAP is the aspiration of bacteria from the oropharynx into the lower
respiratory tract, often facilitated by the presence of endotracheal tubes or mechanical ventilation.
14. How does the acute respiratory distress syndrome (ARDS) affect pulmonary compliance?
ARDS leads to decreased pulmonary compliance due to alveolar flooding, inflammation, and
surfactant dysfunction, which results in stiff lungs and difficulty in expanding the alveoli during
inspiration.
15. What is the significance of central venous pressure (CVP) monitoring in critically ill patients?
CVP monitoring provides insight into the patient’s volume status and right ventricular function,
guiding fluid management and assessing the adequacy of preload in patients with shock or respiratory
distress.
16. How does hyperkalemia affect the cardiac conduction system in critically ill patients?
Hyperkalemia can cause changes in the resting membrane potential, leading to decreased
excitability of myocardial cells, slowed conduction, and potentially life-threatening arrhythmias such as
ventricular fibrillation.
17. What are the main principles of the ABCDE approach in managing critically ill patients?
The ABCDE approach emphasizes the systematic management of Airway, Breathing, Circulation,
Disability (neurological status), and Exposure (assessing for signs of trauma or other abnormalities).
18. What is the role of corticosteroids in the management of septic shock?
Corticosteroids may be used in septic shock to help restore adrenal function, reduce
inflammation, and improve vascular responsiveness to catecholamines, especially in patients with
adrenal insufficiency.
19. Explain how blood gas abnormalities such as respiratory acidosis or alkalosis can indicate specific
types of respiratory failure.
Respiratory acidosis (elevated CO2) typically indicates hypoventilation or obstructive respiratory
failure, while respiratory alkalosis (low CO2) suggests hyperventilation or restrictive lung disease.
20. What is the impact of anemia on oxygen delivery in critically ill patients?
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, Anemia reduces the oxygen-carrying capacity of the blood, leading to a decrease in overall
oxygen delivery (DO2). This can compromise tissue oxygenation, especially in critically ill patients with
low cardiac output.
21. How does the inflammatory response contribute to capillary leak syndrome in critically ill patients?
The inflammatory response increases vascular permeability, causing proteins and fluids to leak
from capillaries into the interstitial spaces, leading to edema and reduced effective circulatory volume.
22. What is the role of blood pressure management in preventing secondary brain injury in traumatic
brain injury (TBI) patients?
Maintaining adequate blood pressure ensures sufficient cerebral perfusion pressure (CPP),
which is critical for preventing secondary brain injury due to hypoperfusion, especially in TBI patients.
23. How does the body react to a sudden decrease in cardiac output during shock?
The body activates compensatory mechanisms, such as increased heart rate, vasoconstriction,
and enhanced sympathetic nervous system activity to maintain perfusion to vital organs despite a
decreased cardiac output.
24. In what ways does acute liver failure contribute to coagulopathy in critically ill patients?
Acute liver failure impairs the production of clotting factors, leading to a deficiency in
coagulation proteins and an increased risk of bleeding, often exacerbated in the ICU setting by
hemodynamic instability.
25. How can the management of blood glucose levels influence outcomes in critically ill patients?
Tight glycemic control can reduce the risk of infections, improve wound healing, and lower the
incidence of sepsis and multi-organ failure in critically ill patients, although it requires careful monitoring
to avoid hypoglycemia.
26. What is the pathophysiology behind the development of cardiac arrhythmias in critically ill patients?
Cardiac arrhythmias in critically ill patients can be caused by electrolyte imbalances, ischemia,
autonomic dysfunction, and hypoxia, which alter the normal electrical conduction of the heart.
27. Why is early goal-directed therapy (EGDT) important in the management of sepsis?
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