PHCL 4020: Chemotherapy: Test Bank |Verified Practice
Questions with A+ Answers | Final Exam Guide FOR 2025/2026
(the most recent quizzes)
What is paraneoplastic syndrome? - syndrome of dysfunction in CA patients not directly
associated with tumor mass or mets
What are 4 examples of endocrine paraneoploastic syndromes?
- 1. SIADH
2. Cushing's syndrome
3. hypercalcemia of malignancy
4. transient hypoglycemia
What is the pathophysiology behind SIADH? - water retention and hyponatremia
THINK: fluid management and neurologic status
What is the pathophysiology behind Cushing's Syndrome? - hyperglycemia, HTN, electrolyte
imbalance
What is the pathophysiology behind hypercalcemia of malignancy? - hypercalcemia
THINK: cardiac conduction and muscle function
What is the pathophysiology behind transient hypoglycemia? - hypoglycemia?
What cancers are transient hypoglycemia associated with? (2) - 1. islet-cell tumors of the
pancreas (produce insulin)
2. nonislet-cell tumors outside of the pancreas (produce insulin-like growth factor 2)
What is a neurologic paraneoplastic syndrome? - Lambert-Eaton Myasthenic Syndrome
What is the patho behind Lambert-Eaton Myasthenic Syndrome? - muscle weakness
, THINK about interactions with NMBs
What is the most common cause of hypercalcemia in hospitalized patients? - cancer
What 2 endocrine paraneoplastic syndromes are associated with small cell lung cancer? -
SIADH and Cushing's syndrome
What is tumor lysis syndrome caused by? - tumor cell destruction from radiation or
chemotherapy
As cells die in tumor lysis syndrome they release what 3 things into the systemic circulation? -
1. uric acid
2. potassium
3. phosphate
Hyperuricemia d/t tumor lysis syndrome puts patients ar risk for what? - acute renal failure
Hyperkalemia d/t tumor lysis syndrome puts patients ar risk for what? - cardiac conduction
abnormalities
hyperphosphatemia d/t tumor lysis syndrome puts patients ar risk for what? - secondary
hypocalcemia leading to dysrhythmias or muscle tetany
What is another name for chemotherapy drugs? - antineoplastic drugs
What is the traditional goal of chemotherapy drugs? - completely eradicate all cancer cells
What is the contemporary goal of chemotherapy drugs? - harness the intrinsic ability of our
immune system to eliminate malignant cells
T/F: chemotherapy drugs are used in short periods because normal cells recover more rapidly
than malignant cells - TRUE
there is less immunosuppression with intermittent administration
T/F: the MOA of all chemotherapeutic agents is the same - FALSE!!!
Questions with A+ Answers | Final Exam Guide FOR 2025/2026
(the most recent quizzes)
What is paraneoplastic syndrome? - syndrome of dysfunction in CA patients not directly
associated with tumor mass or mets
What are 4 examples of endocrine paraneoploastic syndromes?
- 1. SIADH
2. Cushing's syndrome
3. hypercalcemia of malignancy
4. transient hypoglycemia
What is the pathophysiology behind SIADH? - water retention and hyponatremia
THINK: fluid management and neurologic status
What is the pathophysiology behind Cushing's Syndrome? - hyperglycemia, HTN, electrolyte
imbalance
What is the pathophysiology behind hypercalcemia of malignancy? - hypercalcemia
THINK: cardiac conduction and muscle function
What is the pathophysiology behind transient hypoglycemia? - hypoglycemia?
What cancers are transient hypoglycemia associated with? (2) - 1. islet-cell tumors of the
pancreas (produce insulin)
2. nonislet-cell tumors outside of the pancreas (produce insulin-like growth factor 2)
What is a neurologic paraneoplastic syndrome? - Lambert-Eaton Myasthenic Syndrome
What is the patho behind Lambert-Eaton Myasthenic Syndrome? - muscle weakness
, THINK about interactions with NMBs
What is the most common cause of hypercalcemia in hospitalized patients? - cancer
What 2 endocrine paraneoplastic syndromes are associated with small cell lung cancer? -
SIADH and Cushing's syndrome
What is tumor lysis syndrome caused by? - tumor cell destruction from radiation or
chemotherapy
As cells die in tumor lysis syndrome they release what 3 things into the systemic circulation? -
1. uric acid
2. potassium
3. phosphate
Hyperuricemia d/t tumor lysis syndrome puts patients ar risk for what? - acute renal failure
Hyperkalemia d/t tumor lysis syndrome puts patients ar risk for what? - cardiac conduction
abnormalities
hyperphosphatemia d/t tumor lysis syndrome puts patients ar risk for what? - secondary
hypocalcemia leading to dysrhythmias or muscle tetany
What is another name for chemotherapy drugs? - antineoplastic drugs
What is the traditional goal of chemotherapy drugs? - completely eradicate all cancer cells
What is the contemporary goal of chemotherapy drugs? - harness the intrinsic ability of our
immune system to eliminate malignant cells
T/F: chemotherapy drugs are used in short periods because normal cells recover more rapidly
than malignant cells - TRUE
there is less immunosuppression with intermittent administration
T/F: the MOA of all chemotherapeutic agents is the same - FALSE!!!
