1
NAPLEX ANTIBIOTICS NEWEST ACTUAL 2025/2026
WITH COMPLETE QUESTIONS WITH ANSWERS
|GRADED A+/ VERIFIED | UPDATED
MIC - (ANSWER)lowest drug concentration that prevents visibile microbial
growth in 24 hours
gram (+) bacteria species - (ANSWER)staph, strep, EC, clostridium, listeria
which antibiotics exhibit time-dependent killing? - (ANSWER)penicillins,
cephalosporins
how can you increase the killing of a time-dependent antibiotic? - (ANSWER)dose
more frequently, extend the infusion time
example of concentration-dependent antibiotic? - (ANSWER)aminoglycosides
(gentamicin, tobramycin, amikacin)
what are the bacteriostatic antibiotics (protein synthesis inhibitors)? -
(ANSWER)macrolides
aminoglycosides
tetracyclines
clindamycin
linezolid
quinupristin, dalfopristin
, 2
what is the MOA of penicillins, cephalosporins, carbapenems, and vancomycin? -
(ANSWER)cell wall inhibitors - bactericidal
what general ADRs are the black box warning for aminoglycosides? -
(ANSWER)nephrotoxicity and neurotoxicity
what are the aminoglycosides? - (ANSWER)tobramycin
gentamicin
amikacin
what type of nephrotoxicity do aminoglycosides cause? - (ANSWER)ATN - acute
tubular necrosis
what weight do you use to dose aminoglycosides? - (ANSWER)IBW (unless TBW is
less)
*use ABW if obese ( > 30% IBW)
what organisms are aminoglycosides mainly active against? - (ANSWER)gram (-):
GNR, PA
extended interval dosing of the aminoglycosides? - (ANSWER)gent/tobra: 4-7
mg/kg
amikacin: 15-20 mg/kg
, 3
*draw random level within 6-16 hours after dose
adjust body weight (ABW) formula? - (ANSWER)IBW + [0.4(TBW - IBW)]
desired trough (traditional dosing) for gent/tobra? peak? - (ANSWER)trough: < 2
mcg/mL
peak: 5-10 mcg/mL
amoxicilin brand name - (ANSWER)Amoxil
what organisms do the penicillins cover? - (ANSWER)mainly gram (+), some gram
(-)
which penicillin is the DOC in acute otitis media? - (ANSWER)amoxicillin
which penicillin has activity against PA? - (ANSWER)piperacillin
which penicillins do not require renal dosing? - (ANSWER)nafcillin
oxacillin
dicloxacillin
Does Amoxil suspension need to be refrigerated? - (ANSWER)no - stable for 14
days at room temperature
, 4
how do you need to take Pen VK? - (ANSWER)on an empty stomach
what IV fluid is ampicillin only compatible with? - (ANSWER)NS
what are the main penicillin drug interactions? - (ANSWER)probenacid,
allopurinol - increased penicillin levels
may decrease levels of oral contraceptives
what type of killing do cephalosporins exhibit? - (ANSWER)time-dependent
what are the first generation cephalosporins? - (ANSWER)cefazolin and
cephalexin
what organisms are every cephalosporin active against? - (ANSWER)strep/staph
and GNR
which cephalosporins are active against PA? - (ANSWER)cefepime and
ceftazidime
cefazolin brand name? - (ANSWER)Kefzol
cephalexin brand name? - (ANSWER)Keflex
NAPLEX ANTIBIOTICS NEWEST ACTUAL 2025/2026
WITH COMPLETE QUESTIONS WITH ANSWERS
|GRADED A+/ VERIFIED | UPDATED
MIC - (ANSWER)lowest drug concentration that prevents visibile microbial
growth in 24 hours
gram (+) bacteria species - (ANSWER)staph, strep, EC, clostridium, listeria
which antibiotics exhibit time-dependent killing? - (ANSWER)penicillins,
cephalosporins
how can you increase the killing of a time-dependent antibiotic? - (ANSWER)dose
more frequently, extend the infusion time
example of concentration-dependent antibiotic? - (ANSWER)aminoglycosides
(gentamicin, tobramycin, amikacin)
what are the bacteriostatic antibiotics (protein synthesis inhibitors)? -
(ANSWER)macrolides
aminoglycosides
tetracyclines
clindamycin
linezolid
quinupristin, dalfopristin
, 2
what is the MOA of penicillins, cephalosporins, carbapenems, and vancomycin? -
(ANSWER)cell wall inhibitors - bactericidal
what general ADRs are the black box warning for aminoglycosides? -
(ANSWER)nephrotoxicity and neurotoxicity
what are the aminoglycosides? - (ANSWER)tobramycin
gentamicin
amikacin
what type of nephrotoxicity do aminoglycosides cause? - (ANSWER)ATN - acute
tubular necrosis
what weight do you use to dose aminoglycosides? - (ANSWER)IBW (unless TBW is
less)
*use ABW if obese ( > 30% IBW)
what organisms are aminoglycosides mainly active against? - (ANSWER)gram (-):
GNR, PA
extended interval dosing of the aminoglycosides? - (ANSWER)gent/tobra: 4-7
mg/kg
amikacin: 15-20 mg/kg
, 3
*draw random level within 6-16 hours after dose
adjust body weight (ABW) formula? - (ANSWER)IBW + [0.4(TBW - IBW)]
desired trough (traditional dosing) for gent/tobra? peak? - (ANSWER)trough: < 2
mcg/mL
peak: 5-10 mcg/mL
amoxicilin brand name - (ANSWER)Amoxil
what organisms do the penicillins cover? - (ANSWER)mainly gram (+), some gram
(-)
which penicillin is the DOC in acute otitis media? - (ANSWER)amoxicillin
which penicillin has activity against PA? - (ANSWER)piperacillin
which penicillins do not require renal dosing? - (ANSWER)nafcillin
oxacillin
dicloxacillin
Does Amoxil suspension need to be refrigerated? - (ANSWER)no - stable for 14
days at room temperature
, 4
how do you need to take Pen VK? - (ANSWER)on an empty stomach
what IV fluid is ampicillin only compatible with? - (ANSWER)NS
what are the main penicillin drug interactions? - (ANSWER)probenacid,
allopurinol - increased penicillin levels
may decrease levels of oral contraceptives
what type of killing do cephalosporins exhibit? - (ANSWER)time-dependent
what are the first generation cephalosporins? - (ANSWER)cefazolin and
cephalexin
what organisms are every cephalosporin active against? - (ANSWER)strep/staph
and GNR
which cephalosporins are active against PA? - (ANSWER)cefepime and
ceftazidime
cefazolin brand name? - (ANSWER)Kefzol
cephalexin brand name? - (ANSWER)Keflex
