CHEM 232 - Exam 3 Questions and Answers Already Passed Latest Update 2025-2026
Alcohol Activation does what? - Answers Transform alcohol into good leaving group
Dehydration uses what? - Answers Heat
Dehydration mechanism - Answers E1 unless super super extreme heat
If there is a pyridine or HX present do what? - Answers Acid - Base
PBr3/PCl3 what does it do? (generally) - Answers Substitute the alcohol with a good leaving
group
SOCl2 what does it do? (generally) - Answers Substitute the alcohol with a good leaving group
Sulfonyl Chlorides what does it do? (generally) - Answers Substitute the alcohol with a good
leaving group
What two activation reagents use SnAc? - Answers SOCl2 and sulfonyl chlorides
Key things to have with SnAc mechanism - Answers Need Carbonyl connected to a good leaving
group and R group
What should I do if my Ephile does not have a good leaving group for a SnAc mechanism? -
Answers Activate it if it is an alcohol!!!! Then proceed with SnAc.
When does carbocations occur? - Answers secondary and tertiary alcohols as well as secondary
and tertiary ethers when given the change
If there is pyridine... - Answers sweep up them extra mf proton charges
Ether formation products - Answers Alkoxides + alkyl halides (methyl or primary unhindered only)
Strong bases - Answers Charged CNO
Alkoxide + primary hindered or above - Answers No ether for you! Only E2
SOCl2, pyridine, what are the mechanisms that take place? - Answers Acid base, SN2, SnAc
Sulfonyl Chlorides, Pyridine, what are the mechanisms that take place? - Answers Acid base,
SnAc (No Inversion!!!!)
What is the only activation mechanism to not change stereochemistry? - Answers Sulfonyl
Chlorides
To make a ring or epoxide you need... - Answers Halo Hydrin (Chain with reactive ends of
halogens and alcohols) + base
Two alcohols and some acid can give you what? - Answers ether
Alcohol Activation does what? - Answers Transform alcohol into good leaving group
Dehydration uses what? - Answers Heat
Dehydration mechanism - Answers E1 unless super super extreme heat
If there is a pyridine or HX present do what? - Answers Acid - Base
PBr3/PCl3 what does it do? (generally) - Answers Substitute the alcohol with a good leaving
group
SOCl2 what does it do? (generally) - Answers Substitute the alcohol with a good leaving group
Sulfonyl Chlorides what does it do? (generally) - Answers Substitute the alcohol with a good
leaving group
What two activation reagents use SnAc? - Answers SOCl2 and sulfonyl chlorides
Key things to have with SnAc mechanism - Answers Need Carbonyl connected to a good leaving
group and R group
What should I do if my Ephile does not have a good leaving group for a SnAc mechanism? -
Answers Activate it if it is an alcohol!!!! Then proceed with SnAc.
When does carbocations occur? - Answers secondary and tertiary alcohols as well as secondary
and tertiary ethers when given the change
If there is pyridine... - Answers sweep up them extra mf proton charges
Ether formation products - Answers Alkoxides + alkyl halides (methyl or primary unhindered only)
Strong bases - Answers Charged CNO
Alkoxide + primary hindered or above - Answers No ether for you! Only E2
SOCl2, pyridine, what are the mechanisms that take place? - Answers Acid base, SN2, SnAc
Sulfonyl Chlorides, Pyridine, what are the mechanisms that take place? - Answers Acid base,
SnAc (No Inversion!!!!)
What is the only activation mechanism to not change stereochemistry? - Answers Sulfonyl
Chlorides
To make a ring or epoxide you need... - Answers Halo Hydrin (Chain with reactive ends of
halogens and alcohols) + base
Two alcohols and some acid can give you what? - Answers ether
