1|Page
UAMS HEMATOLOGY EXAM #1 |
COMPREHENSIVE Q&A FOR GUARANTEED
SUCCESS
Primary granules appear first, usually as promyelocytes. Secondary granules
appear as myelocytes and increase in number as the cell matures. Other
secondary granules include banded and segmented neutrophils, eosinophils, and
basophils. Neutrophils stain purple because they are acidic and alkaline.
Eosinophils stain red/orange because they are acidic. Basophils stain deep
blue/black because they are alkaline. Tertiary granules develop later but are
harder to stain. -correct-answer-Myeloid cells have granules in their cytoplasm.
What are the different types of granules and how do they appear stained?
Chromatin condensation, delicate purple chromatin to clumped chromatin,
nuclear indentation, C:N ratio decreases, and nucleoli disappear. -correct-answer-
What are the characteristics of nuclear maturation?
Granulopoiesis. 7-11 days. Neutrophil. Main purpose is to phagocytosis bacteria. -
correct-answer-What is the formation of granules called and how long does it
take? What is the most common granule and what is its purpose?
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Myeloblast - found in the bone marrow, may be in peripheral blood in leukemia
patients. No granules are present in the cytoplasm. Nucleus is light purple and
unclumped. Cytoplasm is sparse and basophilic.
Promyelocyte - found in the bone marrow, may be in the blood due to leukemia or
infection. Primary granules will be present in the cytoplasm. Nucleus is round with
slight more clumped chromatin.
Myelocyte - found in the bone marrow, may be in peripheral blood due to
leukemia or infection. Both primary and secondary granules will be in the
cytoplasm. Nucleus may be slightly flattened on one side "dawn of neutrophilia."
Cytoplasm is becoming less blue and more pink. This is the first cell to differentiate
into neutrophil, eosinophil, or basophil.
Metamyelocyte - found in bone marrow or peripheral blood in infections. Smaller
than a myelocyte. Nucleus is kidney bean shaped with chromatin appearing
coarser and closer -correct-answer-What are the myeloid precursor stages for
neutrophils and what are their characteristics?
High N:C ratio, round nucleus, even chromatin with dark clumping, blue
cytoplasm. -correct-answer-What are the characteristics of a lymphocyte?
Largest cell in normal blood, indented/folded nucleus, delicate and pale chromatin
with open spaces, chromatin is "lacy", has blue-gray cytoplasm.
Purpose is to present antigens to lymphocytes. -correct-answer-What are the
characteristics of a monocyte? Monocyte purpose?
, 3|Page
Cytoplasmic granules are red/orange, nucleus is most often bi-lobed but can be
banded. Purpose is to control allergic responses and inflammation, as well as
protect against parasitic infections. -correct-answer-What are the characteristics
of an eosinophil? Purpose?
Large granules that are deep blue or black and so large that nucleus is hidden.
Purpose is to provide cell mediated immunity with histamine. -correct-answer-
What are the characteristics of a basophil? Purpose?
It is a platelet precursor. Platelets form by pinching off from the cytoplasm. They
have no nucleus due to this. -correct-answer-What is a megakaryocyte?
Plasma cells are derived from B cells to make antibodies. -correct-answer-What
are plasma cells?
Performs phagocytosis and is involved in storage of iron along with helping with
immunity. -correct-answer-What is a macrophage or histiocyte?
Osteoclast destroys bone. Osteoblast makes bone. -correct-answer-What is an
osteoclast? Osteoblast?
UAMS HEMATOLOGY EXAM #1 |
COMPREHENSIVE Q&A FOR GUARANTEED
SUCCESS
Primary granules appear first, usually as promyelocytes. Secondary granules
appear as myelocytes and increase in number as the cell matures. Other
secondary granules include banded and segmented neutrophils, eosinophils, and
basophils. Neutrophils stain purple because they are acidic and alkaline.
Eosinophils stain red/orange because they are acidic. Basophils stain deep
blue/black because they are alkaline. Tertiary granules develop later but are
harder to stain. -correct-answer-Myeloid cells have granules in their cytoplasm.
What are the different types of granules and how do they appear stained?
Chromatin condensation, delicate purple chromatin to clumped chromatin,
nuclear indentation, C:N ratio decreases, and nucleoli disappear. -correct-answer-
What are the characteristics of nuclear maturation?
Granulopoiesis. 7-11 days. Neutrophil. Main purpose is to phagocytosis bacteria. -
correct-answer-What is the formation of granules called and how long does it
take? What is the most common granule and what is its purpose?
,2|Page
Myeloblast - found in the bone marrow, may be in peripheral blood in leukemia
patients. No granules are present in the cytoplasm. Nucleus is light purple and
unclumped. Cytoplasm is sparse and basophilic.
Promyelocyte - found in the bone marrow, may be in the blood due to leukemia or
infection. Primary granules will be present in the cytoplasm. Nucleus is round with
slight more clumped chromatin.
Myelocyte - found in the bone marrow, may be in peripheral blood due to
leukemia or infection. Both primary and secondary granules will be in the
cytoplasm. Nucleus may be slightly flattened on one side "dawn of neutrophilia."
Cytoplasm is becoming less blue and more pink. This is the first cell to differentiate
into neutrophil, eosinophil, or basophil.
Metamyelocyte - found in bone marrow or peripheral blood in infections. Smaller
than a myelocyte. Nucleus is kidney bean shaped with chromatin appearing
coarser and closer -correct-answer-What are the myeloid precursor stages for
neutrophils and what are their characteristics?
High N:C ratio, round nucleus, even chromatin with dark clumping, blue
cytoplasm. -correct-answer-What are the characteristics of a lymphocyte?
Largest cell in normal blood, indented/folded nucleus, delicate and pale chromatin
with open spaces, chromatin is "lacy", has blue-gray cytoplasm.
Purpose is to present antigens to lymphocytes. -correct-answer-What are the
characteristics of a monocyte? Monocyte purpose?
, 3|Page
Cytoplasmic granules are red/orange, nucleus is most often bi-lobed but can be
banded. Purpose is to control allergic responses and inflammation, as well as
protect against parasitic infections. -correct-answer-What are the characteristics
of an eosinophil? Purpose?
Large granules that are deep blue or black and so large that nucleus is hidden.
Purpose is to provide cell mediated immunity with histamine. -correct-answer-
What are the characteristics of a basophil? Purpose?
It is a platelet precursor. Platelets form by pinching off from the cytoplasm. They
have no nucleus due to this. -correct-answer-What is a megakaryocyte?
Plasma cells are derived from B cells to make antibodies. -correct-answer-What
are plasma cells?
Performs phagocytosis and is involved in storage of iron along with helping with
immunity. -correct-answer-What is a macrophage or histiocyte?
Osteoclast destroys bone. Osteoblast makes bone. -correct-answer-What is an
osteoclast? Osteoblast?
