Chapter 53 Antineoplastic Drugs Part 2 Cell Cycle–Nonspecific and Miscellaneous Drugs
Sealock Lilley’s Pharmacology for Canadian Health Care Practice
MULTIPLE CHOICE
1. A patient is receiving bicalutamide. Which nursing diagnosis is appropriate for this hormonal
antineoplastic drug?
a. Ineffective tissue perfusion related to cardiotoxicity b.
Disturbed sensory perception related to ototoxicity
c. Activity intolerance related to anemia-induced fatigue
d. Impaired urinary elimination pattern related to hyperuricemia
ANS C
Activity intolerance related to anemia is causing fatigue. Other adverse effects include peripheral
edema, pain, hot flushes, gynecomastia, nausea, and diarrhea.
DIF Cognitive Level Application
2. Large, cumulative doses of doxorubicin (Adriamycin®), a cytotoxic antibiotic, are known to cause
which adverse effect?
a. Severe emesis
b. Cardiomyopathy c.
Lung disease
d. Nephrotoxicity
ANS B
Severe cases of cardiomyopathy are associated with large, cumulative doses of doxorubicin. Routine
monitoring of cardiac ejection fraction is needed.
DIF Cognitive Level Comprehension
, 3. Imatinib (Gleevec®) is indicated as treatment for which type of cancer?
a. Chronic myeloid leukemia
b. Acute lymphocytic leukemia
c. Chronic lymphocytic leukemia d.
Acute myeloid leukemia
ANS A
Imatinib is indicated for the treatment of chronic myeloid leukemia (CML), particularly after failure of
interferon alfa therapy. Imatinib is one of the newest available antineoplastic drugs.
DIF Cognitive Level Comprehension
4. Alkylating drugs can have a profound effect on the patient’s nutritional status. Which laboratory
result will assist the nurse in determining the impact the drug has had on the patient’s nutritional
status?
a. White blood cell (WBC) count
b. Platelet count
c. Alanine aminotransferase (ALT) levels
d. Serum albumin levels
ANS D
Serum levels of albumin and protein should be noted, as should fluid and electrolyte levels.
DIF Cognitive Level Comprehension
5. Which is an adverse effect of estrogen receptor antagonists?
a. Constipation and urinary changes
b. Confusion and tachycardia
c. Hot flashes and pharyngitis
d. Weakness and hypoventilation
ANS C
Sealock Lilley’s Pharmacology for Canadian Health Care Practice
MULTIPLE CHOICE
1. A patient is receiving bicalutamide. Which nursing diagnosis is appropriate for this hormonal
antineoplastic drug?
a. Ineffective tissue perfusion related to cardiotoxicity b.
Disturbed sensory perception related to ototoxicity
c. Activity intolerance related to anemia-induced fatigue
d. Impaired urinary elimination pattern related to hyperuricemia
ANS C
Activity intolerance related to anemia is causing fatigue. Other adverse effects include peripheral
edema, pain, hot flushes, gynecomastia, nausea, and diarrhea.
DIF Cognitive Level Application
2. Large, cumulative doses of doxorubicin (Adriamycin®), a cytotoxic antibiotic, are known to cause
which adverse effect?
a. Severe emesis
b. Cardiomyopathy c.
Lung disease
d. Nephrotoxicity
ANS B
Severe cases of cardiomyopathy are associated with large, cumulative doses of doxorubicin. Routine
monitoring of cardiac ejection fraction is needed.
DIF Cognitive Level Comprehension
, 3. Imatinib (Gleevec®) is indicated as treatment for which type of cancer?
a. Chronic myeloid leukemia
b. Acute lymphocytic leukemia
c. Chronic lymphocytic leukemia d.
Acute myeloid leukemia
ANS A
Imatinib is indicated for the treatment of chronic myeloid leukemia (CML), particularly after failure of
interferon alfa therapy. Imatinib is one of the newest available antineoplastic drugs.
DIF Cognitive Level Comprehension
4. Alkylating drugs can have a profound effect on the patient’s nutritional status. Which laboratory
result will assist the nurse in determining the impact the drug has had on the patient’s nutritional
status?
a. White blood cell (WBC) count
b. Platelet count
c. Alanine aminotransferase (ALT) levels
d. Serum albumin levels
ANS D
Serum levels of albumin and protein should be noted, as should fluid and electrolyte levels.
DIF Cognitive Level Comprehension
5. Which is an adverse effect of estrogen receptor antagonists?
a. Constipation and urinary changes
b. Confusion and tachycardia
c. Hot flashes and pharyngitis
d. Weakness and hypoventilation
ANS C
