ASCP MLS
ASCP MLS Exam Questions and Answers
Question 1
What feature is most often found with patients with a splenectomy on a Wright's
stained blood smear?
Correct Answer
Howell-Jolly bodies
Question 2
Patients with antibody to the following antigen are immune to Hepatitis B:
Correct Answer
Surface antigen (HbSAg)
Question 3
Which two of the following tests are helpful for documenting previous Streptococcal
throat and skin infections:
Correct Answer
ASO titer and Anti-DNase B
Question 4
In mass spectrometry, the "appearance potential" is defined as the:
Correct Answer
Minimum energy required for the appearance of a particular fragment ion in mass
spectrum
Question 5
What is generally accepted as the lower threshold value for semen pH from fertile
males?
Correct Answer
7.2
Page 1 of 33
, ASCP MLS
Question 6
Coulometry:
Correct Answer
An automated method for measuring chloride which generates silver ions in the
reaction
Question 7
Erythroleukemia:
Correct Answer
Also known as Acute Myelogenous Leukemia type M6. This type is associated with
either the presence of both erythroid and myeloid precursors OR strictly erythroid
precursors.
Question 8
Myelomonocytic leukemia
Correct Answer
Is associated with an increase in myeloid and monocytic cell precursors, but not red
blood cell precursors
Question 9
Species that are Lysine (+), arginine (=) and ornithine (+):
Correct Answer
Enterobacter aerogenes, Edwardsiella species and most Serratia species
Question 10
Lysine reaction for all Citrobacter:
Correct Answer
Negative
Page 2 of 33
, ASCP MLS
Question 11
Key identifying characteristic for Pantoa (Enterobacter) agglomerans:
Correct Answer
negative reactions for the three decarboxylases commonly tested ( Lysine, arginine
and ornithine)
Question 12
Which organism is MOST likely responsible for septic reactions associated with Red
Blood Cell transfusions?
Correct Answer
Yersina entercolitica is most likely responsible for septic reactions in transfusions of
Red Blood Cells. This organism is usually acquired by ingestion of contaminated
food and causes mild symptoms of abdominal pain and diarrhea. Growth of Y.
entercolitica is enhanced in iron-rich environments such as red cell components.
Question 13
Gaucher's disease
Correct Answer
The most common lysosomal storage disease caused by insufficient activity of the
lysosomal enzyme glucocerebrosidase that leads to the deposition of
glucocerebroside in cells of the macrophage-monocyte system.
Question 14
Diseases associated with dysfunctions of polymorphonuclear neutrophils (PMNs)
Correct Answer
Chediak-Higashi syndrome (CH), Chronic granulomatous disease (CGD),
Myeloperoxidase deficiency (MPO)
Page 3 of 33
, ASCP MLS
Question 15
Nephrotic Syndrome:
Correct Answer
Caused by damage to the kidneys, especially the basement membrane of the
glomerulus; which causes abnormal excretion of protein and red blood cells in the
urine. Fats are also present in the urine in most cases. A foamy appearance of the
urine is a key characteristic of this condition.
Clinical symptoms include:
Swelling
Weight gain from fluid retention
Poor appetite
High blood pressure
Question 16
Key Biochemical reactions for Enterobacteriaceae:
Correct Answer
The key biochemical reactions by which the family Enterobacteriaceae can be
identified include fermentation of carbohydrates, reduction of nitrates to nitrites
and the absence of cytochrome oxidase activity.
Question 17
ANA
Correct Answer
See 2 quiz #27
Question 18
Prozone effect:
Correct Answer
Results in a false positive reaction; is the result of antibody excess and dilution of
antibody can help prevent its occurrence
Page 4 of 33
ASCP MLS Exam Questions and Answers
Question 1
What feature is most often found with patients with a splenectomy on a Wright's
stained blood smear?
Correct Answer
Howell-Jolly bodies
Question 2
Patients with antibody to the following antigen are immune to Hepatitis B:
Correct Answer
Surface antigen (HbSAg)
Question 3
Which two of the following tests are helpful for documenting previous Streptococcal
throat and skin infections:
Correct Answer
ASO titer and Anti-DNase B
Question 4
In mass spectrometry, the "appearance potential" is defined as the:
Correct Answer
Minimum energy required for the appearance of a particular fragment ion in mass
spectrum
Question 5
What is generally accepted as the lower threshold value for semen pH from fertile
males?
Correct Answer
7.2
Page 1 of 33
, ASCP MLS
Question 6
Coulometry:
Correct Answer
An automated method for measuring chloride which generates silver ions in the
reaction
Question 7
Erythroleukemia:
Correct Answer
Also known as Acute Myelogenous Leukemia type M6. This type is associated with
either the presence of both erythroid and myeloid precursors OR strictly erythroid
precursors.
Question 8
Myelomonocytic leukemia
Correct Answer
Is associated with an increase in myeloid and monocytic cell precursors, but not red
blood cell precursors
Question 9
Species that are Lysine (+), arginine (=) and ornithine (+):
Correct Answer
Enterobacter aerogenes, Edwardsiella species and most Serratia species
Question 10
Lysine reaction for all Citrobacter:
Correct Answer
Negative
Page 2 of 33
, ASCP MLS
Question 11
Key identifying characteristic for Pantoa (Enterobacter) agglomerans:
Correct Answer
negative reactions for the three decarboxylases commonly tested ( Lysine, arginine
and ornithine)
Question 12
Which organism is MOST likely responsible for septic reactions associated with Red
Blood Cell transfusions?
Correct Answer
Yersina entercolitica is most likely responsible for septic reactions in transfusions of
Red Blood Cells. This organism is usually acquired by ingestion of contaminated
food and causes mild symptoms of abdominal pain and diarrhea. Growth of Y.
entercolitica is enhanced in iron-rich environments such as red cell components.
Question 13
Gaucher's disease
Correct Answer
The most common lysosomal storage disease caused by insufficient activity of the
lysosomal enzyme glucocerebrosidase that leads to the deposition of
glucocerebroside in cells of the macrophage-monocyte system.
Question 14
Diseases associated with dysfunctions of polymorphonuclear neutrophils (PMNs)
Correct Answer
Chediak-Higashi syndrome (CH), Chronic granulomatous disease (CGD),
Myeloperoxidase deficiency (MPO)
Page 3 of 33
, ASCP MLS
Question 15
Nephrotic Syndrome:
Correct Answer
Caused by damage to the kidneys, especially the basement membrane of the
glomerulus; which causes abnormal excretion of protein and red blood cells in the
urine. Fats are also present in the urine in most cases. A foamy appearance of the
urine is a key characteristic of this condition.
Clinical symptoms include:
Swelling
Weight gain from fluid retention
Poor appetite
High blood pressure
Question 16
Key Biochemical reactions for Enterobacteriaceae:
Correct Answer
The key biochemical reactions by which the family Enterobacteriaceae can be
identified include fermentation of carbohydrates, reduction of nitrates to nitrites
and the absence of cytochrome oxidase activity.
Question 17
ANA
Correct Answer
See 2 quiz #27
Question 18
Prozone effect:
Correct Answer
Results in a false positive reaction; is the result of antibody excess and dilution of
antibody can help prevent its occurrence
Page 4 of 33
