CHEMOTHERAPY BIOTHERAPY CERTIFICATION|WITH QUESTIONS AND CORRECT
ANSWERS LATEST UPDATE
: Cell cycle - Correct Answer-g1- increase in size s- dna
replicated
g2- cell enlarge and ready to divide
m phase- 2 hours
mitosis - Correct Answer-4 stages, prophase, metaphase, anaphase, telophase
-chemo targets certain points in the process
apoptosis - Correct Answer-programmed cell death
hematopoiesis - Correct Answer-formation of blood cells & how cells differentiate
-myeloid: pre cells mature into RBCs, platelets and WBCs
-lymphoid: pre cells- mature into WBCS
Principles of Biotherapy: p51-95 immunology - Correct Answer--defense against foreign
organisms, homeostasis (destroy aged cells), surveillance
immune responses - Correct Answer-innate: primary line of defense, non specific, no
memory
adaptive: secondary line of defence with specific memry
cytokines - Correct Answer--effect growth and differentiation of WBC
-interferons, tumor necrosis factors, growth factos and interleukins
-small protein molecules released by cells throughout body providing comunication
between cells of the immune system
-regular antiboddy production and function of b cells
vaccines for cancer prevention - Correct Answer--hep B prevents hepatitis and
hepatocellular carcinoma
-hpv vaccine
filgrastim aka neupogen - Correct Answer-SC or IV to derease infection in patients with
neutropenic fever associated with myelosuppressive anticancer treatments for
nonmyeloid malignancies
tbo-filgramstim/ pegfilgrastim - Correct Answer-reduce duration of neutroenia in patients
with non myeloid malignancies
, palifermin - Correct Answer-IV to dec incidence of oral mucositis in patients with hem
malignanies before BMT
sargramostim - Correct Answer-aka leukine - patients with AML following chemo to
shorten neutrophil recovery and reduce incidence of infection
IFN gamma - Correct Answer-reduce frequency and severity o infections related to
granulomatous disease
aldeleukin - Correct Answer-treat renal cell carcinoma and metastatic melanoma
oprevelkin - Correct Answer-prevent severe thrombocytopenia and refuce need for
platelet transfusions in patients with nonmyeloid malig
plerixafor - Correct Answer-with filgrastim to mobilize hematopoeitc stem cells for
collection from peripheral blood of patients
sipuleucel - Correct Answer-castrate resistant prostate cancer
rituximab - Correct Answer-rituxan- treatment of relapsed or refractory low grade
follicular b cell NHL_ first line traetment in combo with chemo in patients with response
-can treat severe rheumatoid arthritis
-can have severe reactions (hypotension, urticaria, angiodema, hypoxia, rigors,
dyspnea, chills, fever, nausea, rash, renal tox)
-premed with tylenol and benadryl
-slow infusion to resolve some side effects, side effects reduce with each infusion
immune system - Correct Answer-1st line: skin , ucous membrane, gut flora
second line: phagocytes:
3rd line antibodies, t and b cells
malignant tumor (cancer) - Correct Answer-cell strcuture different from parent tissue,
cell division uncontrolled, loosely adherent, invade neighboring tissue, establish blood
vessels
Approaches to treatment - Correct Answer-cure: prolonged absence of disease
control: no further growth
and palliation : comfort
neoadjuvant - Correct Answer-therapy in the first step to shrink a tumor before the main
treatment) surgery is given
-chemo, radiation, hormone therapy
adjuvant - Correct Answer-therapy given afer primary treatment to lower risk of cancer
coming back
ANSWERS LATEST UPDATE
: Cell cycle - Correct Answer-g1- increase in size s- dna
replicated
g2- cell enlarge and ready to divide
m phase- 2 hours
mitosis - Correct Answer-4 stages, prophase, metaphase, anaphase, telophase
-chemo targets certain points in the process
apoptosis - Correct Answer-programmed cell death
hematopoiesis - Correct Answer-formation of blood cells & how cells differentiate
-myeloid: pre cells mature into RBCs, platelets and WBCs
-lymphoid: pre cells- mature into WBCS
Principles of Biotherapy: p51-95 immunology - Correct Answer--defense against foreign
organisms, homeostasis (destroy aged cells), surveillance
immune responses - Correct Answer-innate: primary line of defense, non specific, no
memory
adaptive: secondary line of defence with specific memry
cytokines - Correct Answer--effect growth and differentiation of WBC
-interferons, tumor necrosis factors, growth factos and interleukins
-small protein molecules released by cells throughout body providing comunication
between cells of the immune system
-regular antiboddy production and function of b cells
vaccines for cancer prevention - Correct Answer--hep B prevents hepatitis and
hepatocellular carcinoma
-hpv vaccine
filgrastim aka neupogen - Correct Answer-SC or IV to derease infection in patients with
neutropenic fever associated with myelosuppressive anticancer treatments for
nonmyeloid malignancies
tbo-filgramstim/ pegfilgrastim - Correct Answer-reduce duration of neutroenia in patients
with non myeloid malignancies
, palifermin - Correct Answer-IV to dec incidence of oral mucositis in patients with hem
malignanies before BMT
sargramostim - Correct Answer-aka leukine - patients with AML following chemo to
shorten neutrophil recovery and reduce incidence of infection
IFN gamma - Correct Answer-reduce frequency and severity o infections related to
granulomatous disease
aldeleukin - Correct Answer-treat renal cell carcinoma and metastatic melanoma
oprevelkin - Correct Answer-prevent severe thrombocytopenia and refuce need for
platelet transfusions in patients with nonmyeloid malig
plerixafor - Correct Answer-with filgrastim to mobilize hematopoeitc stem cells for
collection from peripheral blood of patients
sipuleucel - Correct Answer-castrate resistant prostate cancer
rituximab - Correct Answer-rituxan- treatment of relapsed or refractory low grade
follicular b cell NHL_ first line traetment in combo with chemo in patients with response
-can treat severe rheumatoid arthritis
-can have severe reactions (hypotension, urticaria, angiodema, hypoxia, rigors,
dyspnea, chills, fever, nausea, rash, renal tox)
-premed with tylenol and benadryl
-slow infusion to resolve some side effects, side effects reduce with each infusion
immune system - Correct Answer-1st line: skin , ucous membrane, gut flora
second line: phagocytes:
3rd line antibodies, t and b cells
malignant tumor (cancer) - Correct Answer-cell strcuture different from parent tissue,
cell division uncontrolled, loosely adherent, invade neighboring tissue, establish blood
vessels
Approaches to treatment - Correct Answer-cure: prolonged absence of disease
control: no further growth
and palliation : comfort
neoadjuvant - Correct Answer-therapy in the first step to shrink a tumor before the main
treatment) surgery is given
-chemo, radiation, hormone therapy
adjuvant - Correct Answer-therapy given afer primary treatment to lower risk of cancer
coming back
